Methods of treating aging related skin changes and of increasing skin thickness with topical administration of N-acyldipeptide derivatives and retinol are described. Combinations of retinol and N-acyldipeptide derivatives, are therapeutically effective for increasing skin thickness, and for treating extrinsic and intrinsic aging and aging related skin changes, such as fine lines, wrinkles, photoaging, hyperpigmentation, laxity, age spots, lentigines, mottled skin, and cellulite.

Methods of treating aging related skin changes and of increasing skin thickness with topical administration of N-acyldipeptide derivatives and retinol are described. Combinations of retinol and N-acyldipeptide derivatives, are therapeutically effective for increasing skin thickness, and for treating extrinsic and intrinsic aging and aging related skin changes, such as fine lines, wrinkles, photoaging, hyperpigmentation, laxity, age spots, lentigines, mottled skin, and cellulite.

The present invention relates to the cosmetic use of an essential oil of Laserpitium siler L., as an active agent for preventing and/or treating skin or keratin disorders associated with constriction of the cutaneous capillary circulation. The invention is also directed towards the cosmetic use of the said essential oil as an active agent for improving the appearance of the lips by increasing the size and/or volume and/or thickness of the lips and/or for (re)modelling them and/or making them smooth, and also to a non-therapeutic cosmetic process for caring for the skin and/or keratin fibers.

The present invention relates to the cosmetic use of an essential oil of Laserpitium siler L., as an active agent for preventing and/or treating skin or keratin disorders associated with constriction of the cutaneous capillary circulation. The invention is also directed towards the cosmetic use of the said essential oil as an active agent for improving the appearance of the lips by increasing the size and/or volume and/or thickness of the lips and/or for (re)modelling them and/or making them smooth, and also to a non-therapeutic cosmetic process for caring for the skin and/or keratin fibers.

Use of a composition for the for the prevention, amelioration and/or treatment of disorders and diseases involving cell, tissue or organ senescence, or for the prevention, amelioration and/or treatment of disorders and diseases involving cell, tissue or organ stress caused by an inflammatory process, the composition comprising a conjugate of quinic acid with at least one molecule of caffeic acid, or a derivative, isomer or salt thereof.

Use of a composition for the for the prevention, amelioration and/or treatment of disorders and diseases involving cell, tissue or organ senescence, or for the prevention, amelioration and/or treatment of disorders and diseases involving cell, tissue or organ stress caused by an inflammatory process, the composition comprising a conjugate of quinic acid with at least one molecule of caffeic acid, or a derivative, isomer or salt thereof.

The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

A cosmetic composition containing a molecular association of bile acid and bile salt is disclosed. The cosmetic composition contains a molecular association in which bile acid molecule or bile salt molecules are physically bonded, and when the molecular association is formed in a composition containing water, the molecular association has an associated structure in the composition.

A cosmetic composition containing a molecular association of bile acid and bile salt is disclosed. The cosmetic composition contains a molecular association in which bile acid molecule or bile salt molecules are physically bonded, and when the molecular association is formed in a composition containing water, the molecular association has an associated structure in the composition.