The present disclosure provides a biodegradable super absorbent polymer including a crosslinked polymer of a monomer including a modified polysaccharide having a maleic acid group (—OCOCH═CHCOOH) and a sulfosuccinic acid group (—OCOCH(SO.sub.3H)CH.sub.2COOH), which exhibits excellent biodegradability without deterioration in physical properties of the super absorbent polymer such as centrifuge retention capacity and absorbency under pressure, and a method for producing the same.

Disclosed herein is a compound of formula I:

##STR00001##

where m, n and R.sup.1 are as defined herein. Also disclosed herein are uses of the compound.

Fungal crosslinked structures, fungal crosslinking systems, and methods for crosslinking a fungal material. The crosslinked fungal material described herein comprises a variety of crosslinkers, crosslinking sites, and various combinations of crosslinks, each forming unique structures. The crosslinked fungal material comprises at least one crosslinking compound attached to a bonding site. The fungal crosslinking system includes a preparation unit, an impregnating unit, a crosslinking unit and a rinsing unit. The preparation unit may partially deacetylate chitin within the fungal material and within chitin nanowhiskers. The impregnating unit impregnates the fungal material with chitin nanowhiskers. The crosslinking unit is configured to crosslink the fungal material and chitin nanowhiskers via genipin to create a composite material. The rinsing unit rinses and removes unreacted genipin material thereby rendering a crosslinked composite material. The resulting crosslinked composite material is stronger and more flexible than the original fungal material with improved chemical and mechanical properties.

A compound includes a polysaccharide moiety and one or more chelating agents. The one or more chelating agents are covalently bonded to the polysaccharide moiety. The polysaccharide moiety can include a glycosaminoglycan moiety, such as a hyaluronic acid polymer or a sulfated glycosaminoglycan moiety. The compound can be used to treat or prevent a disease or disorder in a patient with a metal implant. The compound reduces a concentration of metal particulates or metal ions in the subject.

The present invention relates to a method of producing a chitin oligomer, including subjecting chitin-containing biomass to partial hydrolysis while pulverizing the chitin-containing biomass with a pulverization apparatus in the co-presence of water and an acid catalyst selected from phosphoric acid, nitrous acid, and an organic acid (Method 1); a method of producing N-acetylglucosamine, including hydrolyzing a chitin oligomer obtained by the Method 1 by adding water thereto, followed by heating (Method 2); and a method of producing a 1-O-alkyl-N-acetylglucosamine, including alcoholyzing a chitin oligomer by adding an alcohol thereto (Method 3).

The present invention relates to a hemostatic composition and a method for preparing thereof, and more specifically, relates to a hemostatic composition comprising a cross-linked hyaluronic acid derivative matrix which is suitable to be used for hemostasis and a method of preparation of such a composition.

Provided are a cross-linked hyaluronic acid and use thereof.

Method for producing high molecular weight chitosan comprising milling or grinding chitin and a reagent to produce a chitin/reagent mixture; and aging said chitin/reagent mixture to produce a high molecular weight chitosan. Method for producing low molecular weight chitosan comprising amorphizing chitin; milling or grinding said amorphized chitin and a reagent to produce chitin/reagent mixture; and aging said chitin/reagent mixture producing low molecular weight chitosan.

The invention relates to beads and a composition comprising an aqueous phase comprising a plurality of beads, the beads comprising or consisting in a hydrogel matrix comprising at least one carboxyalkyl chitosan having glucosamine units, N-acetyl-glucosamine units and glucosamine units substituted with a carboxyalkyl group, the carboxyalkyl chitosan being crosslinked by covalent bonds between the carboxyalkyl chitosan chains and/or co-crosslinked by covalent bonds with one or more other polymers.

The invention also relates to processes for their preparation and applications thereof.

The present invention provides a hyaluronic acid derivative having a steryl group introduced therein, wherein a ratio Mw/Mn of a weight-average molecular weight Mw to a number-average molecular weight Mn of the hyaluronic acid derivative is 1.11 or more and 10.0 or less.