A medical sensor system (1) for determining a feature in a human or animal body includes magnetic measurement nanoparticles (10) configured to form reversible chemical bonds with a binding substance, and experience a change in their magnetic relaxation behavior dependent on the formation of such bonds. The sensor system (i) further includes magnetic reference nanoparticles (20) having lesser (and preferably no) binding affinity to the binding substance.

A device for measuring and recording body functions can include a first patch and a second patch. The first patch be applied to a user and include an electrocardiogram (“EKG”) sensor and a first communication circuit. The EKG sensor can be for recording electrical activity data of a heart of the user. The first communication circuit can be communicatively coupled to the EKG sensors for transmitting the electrical activity data. The second patch can be communicatively coupled to the first patch and include a processing device and a second communication circuit. The processing device can be for performing an analysis of the electrical activity data. The second communication circuit can be communicatively coupled to the first communication circuit for receiving the electrical activity data and communicatively coupled to the processing device for transmitting the analysis to a second device.

Systems and methods of generating and applying a synthetic neuromodulatory signal are described. A subject may be put under a particular condition that causes an effect in the subject. While the subject is under the condition, a recording of neurogram signals derived from the condition can be made from the subject. For example, neuronal signals traveling on the vagus nerve of the subject may be monitored and recorded. The neurogram may then be used to create a synthetic neuromodulatory signal that can be administered to a user. When the synthetic neuromodulatory signal is administered to the user, the user may experience the same effect as the subject that had been placed in the condition, even though the user was never put under the same condition.

A method and an apparatus to remove a noise from an electrocardiography (ECG) sensor signal are provided. A noise removing method includes: receiving a sensor signal collected by an electrocardiography (ECG) sensor; extracting an ECG estimation signal from the sensor signal based on a peak value of the sensor signal; determining a first comparison value between the ECG estimation signal and a first reference signal indicating an average form of ECG signals; and classifying the ECG estimation signal as one of an ECG signal and a noise by comparing the first comparison value to a first threshold value.

A method for functional analysis of neurophysiological data by decomposing neurophysiological data and EEG signal to form a plurality of signal features. The signal features may then optionally be analyzed to determined one or more patterns.

Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

A device for examining a pathological interaction between different brain areas, including a stimulation unit, which administers identical stimuli to a patient in a sequential manner, wherein the stimuli stimulate neurons of the patient in the brain areas to be examined, a measuring unit for recording measurement signals that represent a neural activity of the stimulated neurons, and a control and analysis unit for controlling the stimulation unit and for analyzing the measurement signals. The control and analysis unit transforms the measurement signals into the complex plane, examines the distribution of the phases of stimuli of the measurement signals absorbed by the measuring unit in response to the stimuli delivered to the patient, and determines the probability, with which the phase distribution differs from a uniform distribution, in order to ascertain whether a pathological interaction between the brain areas exists.

The present invention provides a method and apparatus for reducing motion artifacts in ECG signals. According to an aspect of the present invention, there is proposed a method of reducing motion artifacts in ECG signals, comprising: acquiring a current beat from a continuously measured ECG signal of a patient; calculating a correlation coefficient between a previous mean value beat and the current beat in the ECG signal; determining the weights to be assigned to the previous mean value beat and the current beat based on the correlation coefficient; and calculating a current mean value beat based on the previous mean value beat, the current beat, and the weights thereof. Accordingly, the novel method of deriving the current mean value beat may reduce ECG artifacts due to patient movement in such a manner that the SNR of the ECG signal can be improved substantially.

The present disclosure discloses a device, system and method for testing cardiac exercise functions. Chronotropic Competence Indices (CCIs) are proposed to quantitatively describe the adaptation capability of cardiopulmonary system in response to exercise intensity variation in terms of heart rate changes, and thereby describes the dynamic process of the heart in the body metabolic process. The present disclosure discloses a device which measures the CCIs in real time by using the wearable technology, and referred to as Cardiac Exercise Test (CET). Compared with the Cardiopulmonary Exercise Testing (CPX) and parameters measured by the CPX such as a maximum oxygen uptake, the CCIs have clear clinical meanings and specific normal reference values; and the CET reduces the risk of the test. It is simple to use, and can be used anytime anywhere. It is of great importance in wide clinical applications, and is of great significance in prevention and rehabilitation of cardiopulmonary disease.

A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to generate filtered ECG signals. The method further includes identifying a heart vector from the filtered ECG signals, and measuring a velocity of the heart vector movement. A change in curvature of the identified heart vector movement is quantified and a risk of ventricular tachycardia is determined based at least on the measured velocity and the quantified change in curvature of the identified heart vector movement.