Systems and methods for providing neural stimulation and recording on a subject using flexible complementary CMOS probes are provided. Disclosed systems can include a flexible probe adapted for insertion into a portion of a brain of the subject, the flexible probe comprising a tail portion and a head portion. The tail portion can include a plurality of electrodes configured to be coupled to the brain and a plurality of front-end amplifiers. Each of the plurality of front-end amplifiers can be configured to amplify a signal received from a corresponding electrode of the plurality of electrodes. The head portion can include one or more inductors configured to enable two-way communication with a wireless reader through a near-field inductive link.

A method for processing EEG signals includes reading the EEG signals from two frontal electrodes of an electroencephalograph (301); converting the EEG signals to a frequency domain (305); determining values of a BIS/BAS response on the basis of an asymmetry between the EEG signals (208). The method includes calculating the asymmetry between the EEG signals in the frequency domain in a frequency range from 26 to 29 Hz.

A multi-site electrode array (100) can include a microneedle array and a set of electrically active sites (115). The microneedle array includes a plurality of microneedles (105) supported on a base substrate (110). The set of electrically active sites (115) can be arranged at and/or near the tip of each microneedle (105), and in many cases along a shaft of the microneedles. Further, at least a portion of the active sites (115) can be independently electrically addressable such that a remaining portion of the active sites (115) are optionally electrically shunted together. In some cases all of the active sites (115) are independently electrically addressable.

One variation of a method for testing contact quality of electrical-biosignal electrodes includes: outputting a drive signalincluding an alternating-current component oscillating at a reference frequency and a direct-current componentthrough a driven electrode; determining that a reference electrode is in improper contact with a user's skin if a reference signal read from the reference electrode excludes a first signal component oscillating at the reference frequency and a second signal component oscillating at an ambient frequency; determining that a sense electrode is in improper contact with the user's skin if the reference signal includes the first signal component and if a sense signal read from the sense electrode excludes a third signal component oscillating at the reference frequency; and generating an electrode adjustment prompt if one of the reference and sense electrodes is determined to be in improper contact with the user's skin.

Disclosed is a biosignal acquisition device for the acquisition, in particular the concurrent or simultaneous acquisition, of optical and electrical biosignals. The optical and electrical biosignals are both received by an analog front end device for biosignals, with an opto-electric converter for converting the optical biosignals into electrical signals. Also disclosed are a system of a plurality of biosignal acquisition devices and a biosignal acquisition method.

A system and method for auto-regulating therapeutic administration to a patient for achieving artificial homeostasis. The system includes a plurality of modules designed to create an automated therapeutic administration system. An auto-regulation module maintains a target vital level within a patient by comparing measured levels with stored target levels; a delivery module delivers an amount of a therapeutic to a patient based on instructions from the auto-regulation module, and a sensor module measures patient levels and transmits the measurements to the auto-regulation unit. The auto-regulation module compares the measured levels with the stored target levels, and, based on the comparison, instructs the delivery module to alter the amount of therapeutic administered to the patient, in an effort to match the measured levels with the target levels, thereby creating a closed feedback loop designed to achieve an artificial homeostasis for a patient.

A neural interface arrangement has multiple probes for subdural implantation into or onto a human brain. Each probe has at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the electrode(s), and a transmitter for wirelessly transmitting data signals arising from the electrode(s). An array of coils is implanted above the dura beneath the skull, for inductively coupling with the coil of each probe, and for transmitting power to the probes. A primary coil is connected to the coil array, for inductively coupling with an external transmitter device, and for receiving power from the external transmitter device. In use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the coil array to transmit power to the probes by inductive coupling, and the probes wirelessly transmit data signals arising from the electrodes.

The present technology relates generally to the field of electrophysiology and specifically to automated devices, components, systems, and related methods for monitoring potential injury to the nervous system using evoked potentials during intraoperative neurophysiologic monitoring.

An electroencephalogram measurement system includes an acquisition unit, an impedance measurement unit, and an output unit. The acquisition unit acquires electroencephalogram information representing an electroencephalogram obtained by an electrode unit that is placed on a region of interest forming part of a subject's head. The impedance measurement unit measures an impedance value between the electrode unit and the subject's body in an acquisition mode in which the acquisition unit acquires the electroencephalogram information. The output unit outputs the impedance value measured.

An implantable device includes one or more electrodes to sense an electrical signal from a brain and a waveform analyzer to identify a half wave in the electrical signal; determine an amplitude and a duration of the half wave; determine if the amplitude satisfies a half wave amplitude criterion defined by a set of amplitude parameters comprising a minimum half wave amplitude and a maximum half wave amplitude; determine if the duration satisfies a half wave duration criterion defined by a set of duration parameters comprising a minimum half wave duration and a maximum half wave duration; and identify the half wave as a qualified half wave when the half wave amplitude criterion and the half wave duration criterion is satisfied. A neurological event may be detected based on one or more qualified half waves and electrical stimulation therapy may be delivered to the brain in response to the detection.