An implantable electrode array is provided, the electrode array comprising a substrate, the substrate having a front side and a back side, and a first number of first electrodes. The first electrodes are formed as contact pads, and are arranged on the front side. The substrate comprises a second number of prefabricated holes at predetermined positions, the holes extending from the front side through the substrate towards the back side, and being arranged such the holes may be penetrated by elongated electrodes placed at the predetermined positions.

A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.

A preferred conformal penetrating multi electrode array includes a plastic substrate that is flexible enough to conform to cortical tissue. A plurality of penetrating semiconductor micro electrodes extend away from a surface of the flexible substrate and are stiff enough to penetrate cortical tissue. Electrode lines are encapsulated at least partially within the flexible substrate and electrically connected to the plurality of penetrating semiconductor microelectrodes. The penetrating semiconductor electrodes preferably include pointed metal tips. A preferred method of fabrication permits forming stiff penetrating electrodes on a substrate that is very flexible, and providing electrical connection to electrode lines within the substrate.

Systems and methods of the present invention provide for storing an annotated set of confirmed epileptiform discharges (ED) waveforms in a database; receiving, by a computing device, a signal encoding electroencephalograph (EEG) data from a plurality of electrodes each attached to a subject and detecting EEG data; generating a user interface displaying a plurality of waveforms based upon at least a portion of the EEG data; receiving an initial selection of a portion of one of the plurality of waveforms comprising an ED; identifying a list of candidate waveforms including potential EDs by determining an alignment of the initial selection with a portion of one of the plurality of waveforms in the EEG data; displaying the list of candidate waveforms on the user interface; receiving, from the user and via the user interface, an identification of a subset of the list of candidate waveforms; and storing the subset of the list of candidate waveforms as an annotated list of confirmed EDs in the database.

The present application relates to an electrode pad comprising at least one electrode with an electrode terminal. A contact member such as a hydrogel is disposed on said electrode terminal and covered by a retainer mesh. The electrode terminal may be, for example, a silver electrode disposed on a flexible foil, and the contact member may be disposed in the aperture of a backing layer. The retainer mesh is designed to allow for an electrical contact of the contact member to an object such as the body of a person while at the same time mechanically retaining the contact member. Moreover, the electrode pad may comprise an array of several electrodes disposed on a carrier, said carrier having a slit separating at least two neighboring electrodes.

An intraoperative multichannel brain probe is presented. The brain probe has a cylindrical upper stainless steel section attached to a lower cylindrical section. In the lower section, an outer cylindrical tube surrounds a second insulating tube. Electrically recording/stimulating wires are placed between the outer tube and the second tube. Each wire has one end protruding out a hole in the outer tube. The other end of each wire is threaded through the entire probe and electrically connected to a recording or stimulating device through a connector system. A number of insulating tubes and electrodes located inside the second tube may also be part of the brain probe. Each inner electrode, typically two, is insulated from each other and from the second insulating tube by other insulating tubes. The combination of one or more wires and electrodes provides a multi-functional device. The brain probe is capable of providing multichannel stimulation and/or recording of brain functions and up to 128 individual electrode conducting sites.

Disclosed are a method and system for brain activity detection. The method is: performing multi-channel synchronous collections of brain electrical signals and cerebral cortex blood oxygen signals simultaneously, and ensuring synchronicity of the collected signals among channels, and collecting said brain electrical signals and said cerebral cortex blood oxygen signals of all locations at the same time. The system comprises: a functional near-infrared light source emission module (2) which employs the frequency division multiplexing technique, wherein the light source is modulated by carrier of different frequencies, said signal is accessed from the multi-functional joint collection helmet (1) through a transmission optical fiber to irradiate the scalp, and after being scattered and absorbed by the brain, the attenuated light signal is processed by the functional near-infrared detection module (3); the functional near-infrared detection module (3) is used for detecting weak optical signals of the scalp; the brain electricity detection module (4) is used for detecting weak electrical signals of the scalp; the central control unit (5) is used for synchronizing and fusing data flows, sending control commands to each functional module, and uploading data to the host computer (6). The method and system can control the interference to be the minimum and have good time scale consistency.

A sensor device which is suitable for receiving and transmitting signals and can be placed on a test person's head, includes a sensor device housing having a signal pin on its distal side for receiving a signal and a connection on its proximal side for the signal transmission of a signal received by the signal pin. A sensor device holder has an axial through opening in which the sensor device housing is disposed so as to be steplessly axially displaceable. When the sensor device housing is axially displaced relative to the sensor device holder, the sensor device housing does not change its radial orientation. A cap having a plurality of sensor devices is also provided.

Disclosed systems include a self-contained electroencephalogram (EEG) recording patch comprising a first electrode, a second electrode and wherein the first and second electrodes cooperate to measure a skin-electrode impedance, a substrate containing circuitry for generating an EEG signal from the measured skin-electrode impedance, amplifying the EEG signal, digitizing the EEG signal, and retrievably storing the EGG signal. The patch also comprises a power source and an enclosure that houses the substrate, the power source, and the first and second electrodes in a unitary package.

An arrangement is disclosed for carrying out electrode measurements on the surface of the skin of a patient's head for recording the electrical activity of the brain, the arrangement including a matrix electrode configuration, which includes a body part of non-conductive material conforming to the contours of the surface of the skin. The arrangement includes electrodes for producing the measurement data connected to the body part, means for transmitting the measurement data connected to the body part, and a measurement data unit for receiving the measurement data transmitted by the means for further processing of the measurement data. The body part can include an electrode placement configuration for maintaining the mutual placements of the electrodes with respect to one another and an active attachment surface located between the electrodes and the surface of the skin to produce measurement data.