Disclosed herein are compositions comprising polymeric perfluorocarbon nanoemulsions and methods of their production, as well as methods for their use in imaging, examination, diagnosis and/or treatment of neurological and psychiatric diseases, as well as for ultrasound- mediated localized drug release into the brain.

A filter method for reducing interferences of a measuring signal, caused by magnetic fields of a rotatable medical imaging system while measuring bioelectric signals in a differential voltage measuring system, the filter method including: capturing a frequency value of a rotation of a gantry of the rotatable medical imaging system; generating a virtual reference signal as a function of the frequency value captured; estimating, via an adaptive signal filter, an amplitude and a constant phase offset of an estimated interference signal, based upon the virtual reference signal generated and a measuring signal; and filtering the measuring signal with the adaptive signal filter by subtracting the estimated interference signal from the measuring signal. A filter apparatus is also described. Furthermore a voltage measuring system is described. Furthermore, a rotating medical imaging system is described.

The present invention is directed to a portable device for quantitative measurement of tissue autoregulation and neurovascular coupling via portable measurement of blood flow, oxygenation, metabolism, and/or EEG signals and methods for using said device. The device may comprise a body and a plurality of legs pivotably attached to the body. The plurality of legs may comprise at least one reference electrode leg and at least one measurement electrode leg for electrical measurement, and an optical detection fiber leg and at least one optical source fiber leg for optical blood flow, oxygenation, and metabolism measurement. The present invention is additionally directed to a portable device for blood flow measurement and therapeutic photobiomodulation. The device may comprise a body and a plurality of legs. The plurality of legs may comprise at least one optical detection fiber leg and at least one optical source fiber leg, and at least one leg for therapeutic photobiomodulation.

Wearable devices and methods for determining a psycho-emotional state of a user are described herein. A wearable device for determining a psycho-emotional state of a user may include a plurality of sensors, an evaluation and testing module, and a processing module. The plurality of sensors may be configured to measure physiological parameters of the user. The evaluation and testing module may be configured to evaluate and test the user. The processing module may be configured to analyze the physiological parameters of the user during one of the evaluation or the testing. The processing module may be further configured to determine the psycho-emotional state of the user based on the analysis. The processing module may be configured to determine changes in the psycho-emotional state of the user. The processing module may be further configured to provide recommendations based on the changes in the psycho-emotional state of the user.

Monitoring apparatus and methods are provided for assessing a physiological condition of a subject. At least two types of physiological information are detected from a subject via a portable monitoring device associated with the subject, and an assessment of a physiological condition of the subject is made using the at least two types of physiological information, wherein each type of physiological information is individually insufficient to make the physiological condition assessment. Environmental information from a vicinity of a subject also may be detected, and an assessment of a physiological condition of the subject may be made using the environmental information in combination with the physiological information. Exemplary physiological information may include subject heart rate, subject activity level, subject tympanic membrane temperature, and subject breathing rate. Exemplary environmental information may include humidity level information in the vicinity of the subject. An exemplary physiological condition assessment may be subject hydration level.

A wearable audio device includes a housing configured to be positioned at an ear of a subject, a speaker and a chipset within the housing. The chipset includes a plurality of sensor elements, at least one signal processor, at least one digital bus, power regulating circuitry, and at least one wireless transmitter. The sensor elements include at least one optical emitter, at least one optical detector, and at least one noise source. The chipset is positioned within the housing such that the at least one optical emitter and at least one optical detector are in optical communication with the ear via a window in the housing. The at least one signal processor includes sensor signal conditioning algorithms configured to process signals from the sensor elements to generate physiological assessment information about the subject. The at least one wireless transmitter is configured to communicate the physiological assessment information to a remote device.

Example methods are disclosed herein that include obtaining electroencephalographic (EEG) data from a subject via a device comprising two or more independently adjustable bands, each of the bands having a plurality of electrodes to detect the electroencephalographic data from a brain of the subject, each band selectively rotatable relative to an adjacent band and each band selectively compressible to increase a force of the electrodes against a head of the subject. The example method also includes converting the EEG data into digital EEG signals and conditioning the digital EEG signals. In addition, the example method includes analyzing the digital EEG signals using one or more analysis protocols to determine a mental characteristic of the subject and transmitting the mental characteristic to an output device.

A mental illness determination device includes a face change information acquisition unit and a mental illness determination unit. The face change information acquisition unit is configured to acquire face change information indicating a time-series change in face data of a subject when emotional stimulation information for stimulating any sense or any combination of senses among an auditory sense, an olfactory sense, a gustatory sense, a tactile sense, and a somatic sensation of the subject to change emotion, and is divided into positive information for increasing comfort and negative information for decreasing comfort is provided to the subject. The mental illness determination unit is configured to determine a state of mental illness of the subject on the basis of the face change information.

A computing device for enhancing communications is disclosed. The computing device includes a memory configured to store data, a video camera configured to receive video input data, and a microphone configured to receive audio input data. The computing device also includes a processor that is configured to analyze the received video input data, the received audio input data, and the data stored in the memory. The computing device further includes a visual display device that is configured to output a visual display based on the processor analysis, and a speaker output device that is configured to output an audio signal based on the processor analysis.

Modular physiological sensors that are physically and/or electrically configured to share a measurement site for the comfort of the patient and/or to ensure proper operation of the sensors without interference from the other sensors. The modular aspect is realized by providing outer housing shapes that generally conform to other physiological sensors; mounting areas for attachment of one sensor to another sensor; providing release liners on the overlapping sensor attachment areas; and/or providing notches, tabs or other mechanical features that provide for the proper placement and interaction of the sensors.