The present disclosure provides systems and methods for generating an electrophysiological map of a geometric structure. The system includes a computer-based model construction system configured to acquire electrical information at a plurality of diagnostic landmark points, assign a color value, based on the acquired electrical information, to each of the diagnostic landmark points, create a first 3D texture region storing floats for a weighted physiological metric, create a second 3D texture region storing floats for a total weight, for each diagnostic landmark point, additively blend the color value of the diagnostic landmark point into voxels of the first 3D texture region that are within a predetermined distance, normalize the colored voxels using the second 3D texture region to generate a normalized 3D texture map, generate the electrophysiological map from the normalized 3D texture map and a surface of the geometric structure, and display the generated electrophysiological map.

A system for processing ECG recordings from multiple patients includes a preprocessing database containing unprocessed ECG records from multiple patients, a reporting database containing processed ECG records from multiple patients, a processor, and a triage module executable on the processor to assess each of the unprocessed ECG recordings from the multiple patients. The triage module is executable to detect a presence or absence of one or more known abnormalities and determines at least one abnormality identifier based on the detected known abnormality. One or more abnormality groups are then identified based on the abnormality identifiers. A normal group of ECG recordings from multiple patients is then identified from those ECG recordings that are not in the abnormality group. The normal group of ECG recordings is then stored in the reporting database then associated a normal identifier.

The invention discloses a method, a system, a computer program and a device for determining the surface charge and/or dipole densities on heart walls. Using the foregoing, a table of dipole densities (P, t) and/or a table of surface charge densities (P, t) of a given heart chamber can be generated.

The disclosed methods pertain to diagnosing whether a non-ablative, gene therapy is needed for reducing AF fibrosis in a subject, and if so, methods of reducing AF fibrosis in a subject using gene therapy with a dominant negative TGF- R2 cDNA expression vector. Kits and computer program products are also described, wherein the kits provide materials for diagnosing and treating AF fibrosis, and the computer program products include a computer readable medium having computer readable program code for monitoring the efficacy of therapeutic ablation of fibrosis in a subject using a gene therapy method.

Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally (in the midline) on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow hourglass-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and, to a lesser extent, the QRS interval signals indicating ventricular activity in the ECG waveforms. Additionally, the monitor recorder includes an ECG sensing circuit that measures raw cutaneous electrical signals and performs signal processing prior to outputting the processed signals for sampling and storage.

The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

An example method includes analyzing morphology and/or amplitude of each of a plurality of electrophysiological signals across a surface of a patient's body to identify candidate segments of each signal satisfying predetermined conduction pattern criteria. The method also includes determining a conduction timing parameter for each candidate segment in each of the electrophysiological signals.

Disclosed herein are methods of treating cardiac arrhythmia with electronic monitoring in a timely manner. Also disclosed herein are systems for electronic monitoring of cardiac arrhythmia.

Disclosed are devices, a systems, and methods for determining the dipole densities on heart walls. In particular, a triangularization of the heart wall is performed in which the dipole density of each of multiple regions correlate to the potential measured at various locations within the associated chamber of the heart.

In one embodiment, an ambulatory encoding monitor recorder optimized for rescalable encoding and a method of use are provided. The monitor recorder includes a memory configured to store a plurality of codes and a plurality of electrocardiographic values associated with each of the codes; and a micro-processor configured to obtain electrocardiographic values during a sequence of temporal windows and to process the electrocardiographic values within each of the windows, the processing including: perform a mathematical operation on two of the electrocardiographic values; analyze a result of each of the mathematical operations; based on the analysis, adjust the plurality of the electrocardiographic values associated with each of the codes; encode each of the electrocardiography values within that window with one of the codes based on the adjusted plurality of the electrocardiographic values associated with that code; and write each of the codes into a sequence in the memory.