Provided are systems and methods for rational selection of context sequences and sequence templates including a computer implemented method for obtaining a repository of attributes sets where the attributes sets are statistically associated with a sequence template representing two or more context sequences.

Method for locating anomalous features in medical images in which medical images are supplied by an external source. A sequence of specific measurements is executed on the supplied data to obtain image-related metrics. The metrics are compared to corresponding values in a database resulting in an anomalous/not anomalous determination. Anomalous determinations are presented to the test operator for analysis along with supplemental historical data. In application to all types of medical imagery, potential anomalies are located resulting in an efficient and accurate diagnosis. For paired body parts having symmetrical properties, as a pre-screening stage, a line of symmetry between the body parts is determined and symmetric regions of the two body parts on opposite sides of the determined line of symmetry are analyzed for differences. The metric comparison using the database is performed between both symmetric regions only when differences between the symmetric regions of the subject medical image are present.

Systems and methods for discovery and characterization of neuroactive drugs are provided. In some aspects, a method for evaluating an effectiveness of a drug administered to a subject includes receiving neurophysiological data acquired from a subject under an administration of a drug, and analyzing the neurophysiological data to generate signatures indicative of brain states induced by the drug. The method also includes correlating the generated signatures with a database comprising information associated with a plurality of drug profiles, and determining, using the information, a molecular activity profile for the drug. The method further includes generating a report indicative of the effectiveness of the drug using the molecular activity profile.

Data-driven generalized regression-based frameworks that support the transformation of measurements, applicable but not limited to gene expressions, from one platform to another over a wide dynamic range, with selected summary statistics/feature values as predictors for the model parameters. The framework consists of primary model training and transformation, and additional levels of categorical regression and transformation processes.

The present invention describes a biomolecule based storage system for converting, storing the data in DNA coded form and retrieving data using pointer file approach. User input data is converted into 4base DNA sequence, called Nibble, which is further mapped onto the DNA sequence of an organism. The first position of each converted nibble is then obtained and stored in a pointer file. By mapping the positions of pointer file onto the DNA sequence of the organism, the data can be retrieved.

In an embodiment, a method includes loading, from a first database, a representation of an Equipped-Human Reference Architecture (EHRA) model that is based on a human-equipment-task framework. The method further includes, based on indications of polymorphic attributes of at least one of a human, a task, an equipment, and an operational environment as defined by the EHRA model, selected by a user, loading a plurality of properties associated with the received indications from a second database. The method further includes polymorphically adding the plurality of properties to the representation of the EHRA model. The method further includes providing an equipped human system (EHS) solution architecture based on the EHRA model with the plurality of properties by analyzing one or more needs of the human, the task, the equipment, and the operational environment and determining an EHS solution meeting each need. The method further includes updating the EHRA model based on EHS solution architecture.

Systems and methods for conducting secure, privacy-preserving, verifiable omic transactions are provided. An omic service may authenticate one or more individual users and store each users omic information as encrypted data, without storing decryption keys, and also ensure fidelity and correct correspondence of each user's data with the user. A dedicated private virtual appliance can be instantiated to obtain encrypted omic data, query each user for decryption keys, decrypt the user omic data, perform an omic calculation, report results and terminate itself, thereby erasing all copies of decrypted user omic data. Alternatively, the appliance can operate with user-managed genome storage. A genome-on-a-stick construct facilitates end user interaction with such omic service providers.

Methods and systems for detecting abnormal karyotypes are disclosed. An example method can comprise determining read coverage data, allele balance distributions of heterozygous SNPs, and chromosomal segments where heterozygosity is not observed. The methods and systems can then determine one or more metrics which can be indicative of abnormal karyotype(s).

Mechanisms are provided for determining the meaning of medical values in natural language content. The mechanisms receive patient information from a source which includes at least one of text or a numerical value indicative of a medical value corresponding to a patient. The mechanisms perform cognitive natural language processing on a context of the text or numerical value in the patient information and determine a meaning of the medical value based on results of the cognitive natural language processing. The mechanisms then process the patient information from the source based on the determined meaning of the medical value.

Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.