The invention relates to a method of preventing or treating pathogenic bacterial infectious diseases by providing a pharmaceutical composition comprising a LysSAP26 protein, wherein the LysSAP26 protein is a recombinant protein composed of an amino acid sequence derived from the bacteriophage genome and has the amino acid sequence set forth in SEQ ID NO: 1 as an active ingredient, and administering the pharmaceutical composition to a subject.

The present invention relates to an antimicrobial composition having activity against Gram-positive and Gram-negative bacteria. The composition is a) a composition comprising at least two organic acids selected from the group consisting of lactic acid, acetic acid, benzoic acid and citric acid; b) a composition comprising at least two bacteriocin selected from the group consisting of pediocin, Nisin and reuterin; c) a composition comprising pediocin and at least two organic acids selected from the group consisting of lactic acid, acetic acid, benzoic acid and citric acid; or d) a composition comprising reuterin and at least one organic acid selected from the group consisting of lactic acid, acetic acid, benzoic acid and citric acid. The present invention also relates to the use of said compositions for sanitizing and/or disinfecting surfaces and method thereof.

The present disclosure relates, according to some embodiments, to systems, compositions, and methods for sanitizing a food product with an alkaline antimicrobial composition. For example, the present disclosure relates, in some embodiments, to a composition for sanitizing a food product with regard to at least one microorganism without substantial residue of the composition left on the sanitized food product, the composition comprising (a) at least one quaternary ammonium compound (b) a base, and (c) at least one solubility enhancing agent. The present disclosure also relates to a system for sanitizing a food product, the system comprising a housing, a plurality of work pieces passing through the housing, a conduit for applying an alkaline antimicrobial composition to the work pieces, and a chiller.

Citrus-based antimicrobial compositions having broad spectrum antimicrobial activity against microorganisms such as bacteria, yeast, molds and fungi are described. The citrus-based antimicrobial compositions are suitable for use in food products, personal care products, oral products, or as surface/topical antimicrobials. The antimicrobial compositions generally comprise citrus extract as the principal antimicrobial ingredient, as well as a relatively low concentration of lauric arginate as an additive. In some embodiments, advantageous ingredient ratios of the citrus extracts to lauric arginate are provided. In some embodiments, formulations comprising the citrus-based antimicrobial compositions and taste-enhancing agents are provided, which mask the unpleasant taste that may be associated with the citrus extract, allowing for its use in food products. Methods of preparing antimicrobial citrus extracts and antimicrobial compositions, uses thereof, and products comprising same are also described.

Provided is a nanoemulsion which has stability and to which preservative efficacy is imparted, in a bacterial contamination environment. This object is attained by a nanoemulsion which has an average particle diameter of 30 nm or less, has a particle size distribution index of 0.14 or less, does not contain particles of 100 nm or more, and contains, as a preservative, at least one selected from an organic acid (salt) and a biguanide-based compound.

The present invention aims to provide a technique to effectively inhibit microorganism growth in an oral composition and the like. The present invention relates to a composition containing (A) L-ergothioneine or a salt thereof and (B) quercetin or a glycoside thereof.

The disclosure relates to systems and methods for improving the manufacturing of silk solutions and powders containing silk fibroin obtained from silkworm cocoons. The systems include a reactor vessel to degum, rinse, and dissolve the silk fibroin protein from silk inputs to obtain a purified silk fibroin-based solution. The reactor vessel may include a combination of inputs and outputs for introducing and removing different components used or generated during the disclosed processes. The systems may include any combination of heat exchangers, holding tanks, filtration modules, and post-treatment equipment as necessary to obtain the silk powder. The solutions and powders can be used to improve the post-harvest preservation of perishables and to improve the performance of packaging, including biodegradable packaging.

One aspect of the present invention is concerned with a composition containing: (A) at least 10 g of particular substituted pyrroles per kg of dry matter; and (B) at least 100 mg per kg of dry matter of a pyranone selected from the group consisting of maltol, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and combinations thereof;
which composition, when dissolved in water at a dry solids content of 0.1 wt. %, exhibits: i. an absorption at 280 nm (A.sub.280) that exceeds 0.01, preferably exceeds 0.05; and ii. an absorption ratio A.sub.280/560 of at least 100, preferably of at least 200. The present composition can advantageously be used as an additive in beverages or foodstuffs to prevent or reduce light induced flavor changes. The invention also encompasses a process for the manufacture of the aforementioned composition.

The present invention relates to a peptide having a fungicidal activity, isolated from Lactobacillus plantarum YML007, and provides a fungicidal peptide comprising the amino acid sequence of SEQ ID NO: 1. In addition, the present invention provides a fungicidal composition or a composition for food preservation, containing the peptide as an active ingredient. The peptide of the present invention has a wide range of fungicidal activities, and thus can be applied, by using the same, to various fields such as a microbial preparation related to fungicidal activity, an agent for controlling pathogenic fungi, a preservative for food including feed, and the future development of medical supplies related to fungi.

A composition containing 3-hydroxyanthanilic acid (3HAA) and a compound that alters iron homeostasis (an iron chelator or an iron supplement). The combination may be used as a new antibiotic drug. Combining 3HAA with iron chelation may have the dual benefit of inhibiting pathogen growth while repressing the pathological hyperinflammatory response in septic individuals. The combination may be effective at preserving food by preventing bacterial growth.