An electrode configured to provide electrical contact with the skin of a user and configured to be positioned on or near a mastoid region of the user is provided. The electrode comprises an electrically conductive contact configured to receive electrical signals from the skin of the user, and a skin coupler that couples the contact with the skin of the user. The skin coupler comprises an adhesive layer that adhesively engages the skin. The skin coupler also comprises a base region that surrounds the contact, and at least two extension regions that extend away from the base region.

Systems and methods for sonifying electrical signals obtained from a living subject, particularly EEG signals, are disclosed. A time-domain signal representing the activity of an organ is obtained. A voltage of the time-domain signal over a time block is determined. An acoustic signal based on the time-domain signal over the time block is produced. The acoustic signal comprises one or more audibly discernible variations representative of the activity of the organ. If the determined voltage is over a threshold voltage, the time-domain signal is squelched over at least a portion of the time-block as the acoustic signal is produced. The time-domain signal can be squelched by ramping down the signal as an input to produce the acoustic signal. The frequency spectrum of the acoustic signal can also be adjusted as it is produced, such as by flattening the signal and/or attenuating high frequencies along the frequency spectrum of the signal.

An example system includes an analyzer to identify first activity in first neuro-response data, the first activity generated in response to exposure of a subject to a first stimulus prior to exposure to an advertisement or entertainment; identify second activity in second neuro-response data, the second activity generated in response to re-exposure of the subject to the first stimulus after to exposure to the advertisement or entertainment; calculate a differential event related potential measurement; and calculate a differential event related power spectral perturbation. The example system includes a resonance estimator to determine a subject resonance measurement to the advertisement or the entertainment based on the differential event related potential measurement and adjust at least one of the subject resonance measurement or the differential event related potential measurement based on the differential event related power spectral perturbation to generate an adjusted subject resonance measurement.

Methods for determining the likelihood that a subject will be a placebo responder in a clinical study are provided. Also provided are methods for eliminating likely placebo responders from a clinical study a priori, thereby simplifying data analysis and minimizing or eliminating any confound that arises in the analysis as a result of placebo response. Databases and computer systems using the methods are also disclosed herein. Methods for assessing likelihood of a subject experiencing a response shift are also provided.

The present invention is for a method and system for pain classification and monitoring optionally in a subject that is an awake, semi-awake or sedated.

Disclosed is an audio-headset for acquisition of a bio-signal from a subject, including a first earpiece; a second earpiece; an arch connecting the first earpiece and the second earpiece; the arch including a hub (4); wherein the arch, the first earpiece and the second earpiece are configured so that the earpieces are placed over a subject's ears when the audio headset is worn by the subject; and at least one posterior branch (1) having a first end extending from the hub and a second free end; the at least one posterior branch (1) including a concave surface with a radius of curvature, a collapsed state when the headset is not worn by the subject and an expanded state when the headset is worn by the subject.

An ear tip for an earpiece including a body having first and second ends, an inner wall extending between the first and second ends to define a hollow passage to conduct sound waves, and an outer wall connected to the inner wall of the body at the first end and tapering away from the inner wall toward the second end. The ear tip further includes first and second electrically conductive elements arranged on an outer surface of the deformable outer wall.

Optokinetic nystagmus (OKN) is an eye movement elicited by the tracking of moving objects in a visual field. It is characterized by an alternating smooth pursuit in one direction and saccadic movement in the other direction. The presence or absence of OKN indicates whether or not the moving stimulus was visible to the observer, without the explicit cooperation of the observer. It can be a tool for objective visual acuity assessment for patients such as young children who lack cognitive, attentional and language capabilities. Since the patient's head movement and unstable eye gaze may occur during the test, which often brings noises and irrelevant activities in the responses, making recognition of presence/absence of the OKN a challenging task. The present invention, using a dynamic velocity threshold (DVT) filter, provides a system and method for a quick and reliable OKN test and quantitative assessment of visual acuity.

A system for monitoring the cardiopulmonary functioning of a person includes a remote terminal and a sensor module configured to be worn by the person. The sensor module includes at least one physiological sensor configured to sense the following types of physiological information generated by the person: pulse rate, blood flow, and blood pressure; at least one signal processor configured to process signals generated by the at least one physiological sensor; and at least one transmitter responsive to the at least one signal processor that is configured to transmit at least one signal to the at least one remote terminal. The at least one signal processor is configured to focus processing resources on one of the types of physiological information in response to a specified preference by the person.

Apparatus for evoking and sensing ophthalmic physiological signals in an eye, the apparatus comprising: an elongated tubular light pipe having a longitudinal axis, a distal end and a proximal end, the distal end terminating in a spheroid recess; an active electrode having a distal end and a proximal end, the active electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the active electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; and a reference electrode having a distal end and a proximal end, the reference electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the reference electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; wherein the distal end of the active electrode is located closer to the longitudinal axis of the elongated tubular light pipe than the distal end of the reference electrode.