A sample analysis system and method, a sample image analysis system, and a hematology analyzer, the sample analysis system including at least one hematology analyzer, a controller, a first transport device, a sample slide preparation device and a sample image capturing device, wherein one of the hematology analyzers is configured to analyze a first test blood sample of a subject so as to obtain a sample analysis result; the controller is configured to control the first transport device to transport the first blood sample to the sample slide preparation device when the sample analysis result meets a preset condition; the sample slide preparation device is configured to prepare a sample slide of the first blood sample; the sample image capturing device is configured to image a sample region in the sample slide so as to obtain a sample image; and the controller is further configured to generate a retest instruction when the sample image includes information indicating that the first blood sample is an abnormal sample, and to send the retest instruction to one of the hematology analyzers. The foregoing systems and methods enable controlling the hematology analyzers according to the sample image.

Disclosed is a specimen analyzer for analyzing an analyte in a specimen, the specimen analyzer including: a measurement unit including a plurality of first sample preparation parts each configured to prepare a first measurement sample on the basis of the specimen and a first reagent, a second sample preparation part configured to prepare a second measurement sample on the basis of the specimen and a second reagent, and an optical detection part configured to obtain a first optical signal from the first measurement sample and obtain a second optical signal from the second measurement sample; and an analysis unit configured to analyze first data that corresponds to the first optical signal and second data that corresponds to the second optical signal, wherein the analysis unit executes analysis of a first measurement item with respect to the first measurement sample, through a first analysis operation of processing the first data according to an artificial intelligence algorithm, executes analysis of a second measurement item with respect to the first measurement sample, through at least one of the first analysis operation and a second analysis operation of processing a first representative value, of the first data, that corresponds to a feature of the analyte, and executes analysis with respect to the second measurement sample, through a third analysis operation of processing a second representative value, of the second data, that corresponds to a feature of the analyte.

This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting blood cells in biological samples. A small unmeasured quantity of a biological sample such as whole blood is placed in the disposable test cartridge which is then inserted into the cell analyzer. The analyzer isolates a precise volume of the biological sample, mixes it with self-contained reagents and transfers the entire volume to an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping, when it is transferred into the imaging chamber. Images of essentially all of the cellular components within the imaging chamber are analyzed to obtain counts per unit volume. The devices, apparatus and methods described may be used to analyze a small quantity of whole blood to obtain counts per unit volume of red blood cells, white blood cells, including sub-groups of white cells, platelets and measurements related to these bodies.

A method of generating smear quality control information according to an embodiment may include: obtaining a plurality of image data from a plurality of smears, respectively; obtaining, from the plurality of image data, feature values each of which reflects a staining state of each smear; and generating quality control information based on the feature values.

Devices and methods for measuring analytes and target particles in a sample are disclosed. In some embodiments, the disclosure provides a cartridge device. In other embodiments, the disclosure provides a method of using a cartridge device as disclosed herein for analyzing analytes and target particles in a sample. In further embodiments, the disclosure provides an analyzer including a cartridge device and a control unit device. The control unit device is configured to receive, operate, and/or actuate the cartridge device. In some embodiments, the disclosure provides a method of using an analyzer as disclosed herein for analyzing analytes and target particles in a sample.

A blood sample collector can be used to collect a blood sample from a subject. The blood sample collector can be placed in a receptacle of a spectrometer to measure spectral data from the blood sample while the blood sample separates. The container may comprise a window to allow light such as infrared light to pass through the container, with the blood sample at least partially separating within the container between spectral measurements, which can provide improved accuracy of the measurements and additional information regarding the sample. The container may comprise an elongate axis and the container configured for placement in the spectrometer receptacle with the elongate axis extending toward a vertical direction in order to improve gravimetric separation of the blood sample. The spectrometer can be configured to measure the blood sample at a plurality of heights along the sample as the sample separates.

Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.

The invention relates to a method for detecting a dengue infection in a patient blood sample, comprising the steps: a) Performing an analysis of prespecified parameters of blood platelets and prespecified types of blood cells in the sample and determining parameter values for the prespecified parameters of the platelets and the prespecified types of cells; b) Obtaining sample parameters from the values determined in step a); and c) Evaluating the sample parameters in relation to a prespecified criterion, wherein, if the criterion is fulfilled, a dengue infection is present.

Disclosed are devices and methods for analyzing an analyte, such as white blood cells in liquid samples.

An optical detection system, a blood cell analyzer and a platelet detection method are provided. The optical detection system includes: an optical subsystem, a flow chamber and a first detector; the optical subsystem includes a laser, a front optical assembly including an optical isolator, and a rear optical assembly including a blocking diaphragm. The laser is configured to emit a laser beam; the front optical assembly is configured to perform front optical treatment; the rear optical assembly is disposed downstream of the flow chamber in the propagation direction of the laser beam, and is configured to perform rear optical treatment on the scattered light and the laser beam converged at the blocking diaphragm; and the optical isolator is configured to isolate reflected light that is generated when the laser beam passes through the flow chamber.