The present invention describes a fluidic device for measuring at least one of corpuscle mass density and weight. The fluidic device comprises a sedimentation chamber fluidly connected to an inlet channel configured to be immersed in a liquid. The fluidic device further comprises a pumping system connected to the sedimentation chamber. The pumping system is adapted to control the flow of liquid in the sedimentation chamber. A processor of the fluidic device is configured to obtain corpuscle data related to a corpuscle in at least one region of the sedimentation chamber; and calculate at least one of corpuscle mass density and weight based on the data received.

The present invention relates to a microfluidic particle analysis device comprising an inlet in fluid communication via a main channel defining a main flow direction with an inlet manifold providing parallel fluid communication with a bypass channel of hydrodynamic resistance R.sub.bypass, and a measuring channel of hydrodynamic resistance R.sub.measuring, the measuring channel having a cross-sectional dimension in the range of from 1 μm to 50 μm and further having a sensor system for detecting a particle, wherein a flow distribution parameter X.sub.measuring=R.sub.measuring.sup.−1(R.sub.measuring.sup.−1+R.sub.bypass.sup.−1).sup.−1 is in the range from 10.sup.−6 to 0.25, wherein the angle of the measuring channel relative to the main flow direction is in the range of 0° to 60°, and wherein the angle of the bypass channel relative to the main flow direction is in the range of 0° to 60°, and the microfluidic particle analysis device further comprising an outlet in fluid communication with the bypass channel and the measuring channel. The present invention relates to a method of using the device microfluidic particle analysis.

The present invention refers to a device for the analysis of a particle comprising an analysis chamber adapted to contain a positioning fluid. A parameter of the particle suspended in the positioning fluid is detected by means of a detection and control unit. A positioning unit, during a particle analysis operation, is activated and deactivated on the basis of the detected parameter of the particle. The detection and control unit can activate the at least one positioning unit so as to generate a temporary positioning flow in the positioning fluid, such that said temporary positioning flow acts directly on the particle and drives the position of the particle so as to move it into a predefined position in the analysis chamber. The detection and control unit can also deactivate the at least one positioning unit when the particle to be analyzed is in the predefined position, such that the positioning fluid is at rest.

The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.

A portable electronic device is operable in a particulate matter concentration mode where the portable electronic device uses a self-mixing interferometry sensor to emit a beam of coherent light from an optical resonant cavity, receive a reflection or backscatter of the beam into the optical resonant cavity, produce a self-mixing signal resulting from a reflection or backscatter of the beam of coherent light, and determine a particle velocity and/or particulate matter concentration using the self-mixing signal. The portable electronic device is also operable in an absolute distance mode where the portable electronic device determines whether or not an absolute distance determined using the self-mixing signal is outside or within a particulate sensing volume associated with the beam of coherent light. If not, the portable electronic device may determine a contamination and/or obstruction is present that may result in inaccurate particle velocity and/or particulate matter concentration determination.

A system for fluorescence activated cell sorting includes at least two excitation lasers having different orientations relative to an objective such that light from the at least two lasers passes through the objective and intersects a fluidic channel at different positions within an interrogation region. The fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region. The system further includes at least one detector and at least one optical element that directs light emitted from the plurality of fluorescently labeled particles and transmitted through the objective to the at least one detector. The system may further include optics for generating and detecting side and forward scattered light. Methods for operating example systems to collect fluorescent, side scattered and forward scattered light from a plurality of particles are also described herein.

A specimen processing system includes a plate for supporting a specimen system, wherein the specimen system includes a container and a specimen contained therein. The specimen processing system further includes a camera disposed above the plate and configured to generate images of the specimen system, a light source disposed beneath the plate for radiating light towards the plate, a light stop for blocking a portion of the light from reaching the specimen system to produce darkfield illumination of the specimen at the camera, and one or more processors electronically coupled to the camera and configured to track a position of the specimen within the specimen container during a specimen processing protocol based on the images.

Methods and devices for fluidic-based automated regulation of liquid-suspended particles and plug removal (of particles) from possible choke points in the liquid flow channel and methods for multiple parallel particle processing are disclosed. The apparatus comprises flow channels, flow direction means, particle detectors and a control unit.

An analytical device for analysing ions is provided comprising a separator 2 for separating ions according to a physico-chemical property and an interface 3 comprising one or more ion guides. A quadrupole rod set mass filter 4 is arranged downstream of the interface 3. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator 2 through the interface 3 with a first transit time t1; and (ii) to transmit a second group of ions which subsequently emerges from the separator 2 through the interface 3 with a second different transit time t2.

The present invention provides an online measuring method of particle (such as bubbles, droplets and solid particles) velocity in multiphase reactor. The method based on an online multiphase measuring instrument includes the following steps: (1) the online multiphase measuring instrument is placed into the multiphase reactor, and then a particle image produced by two or more exposures are obtained; (2) the actual size of individual pixel in the particle image is determined; (3) valid particles are determined in the depth of field; (4) then the centroid coordinates are conversed to the actual length of the coordinates (x.sub.t,i, y.sub.t,i) and (x.sub.t+Δt,i, y.sub.t+Δt,i) using the actual size of individual pixel. Thus, the instantaneous velocity of particles can be calculated by

[00001]$V_i=\sqrt{\frac{{\left(x_{t+\Delta .Math..Math.t,i}-x_{t,i}\right)}^2+{\left(y_{t+\Delta .Math..Math.t,i}-y_{t,i}\right)}^2}{\Delta .Math..Math.t}}.$

The method can realize real-time measurement of the velocity distribution of bubbles, droplets or solid particles in a multiphase reactor, and the measurement accuracy is high.