The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency). The system may also be used for synthesis optimization.

The present invention provides compositions and methods for determining a saccharide level in a sample. In particular, compositions and methods of the invention include a boronic acid moiety that forms a complex with a saccharide.

The present invention relates to an assay for detecting secreted proteome acidic and rich in cysteine (SPARC), and more specifically to its use in evaluating lung cancer.

The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

The disclosure relates to a manufactured composition, material or device comprising at least two different nonradioactive isotope atoms. Each nonradioactive isotope atom is present in an amount sufficient to increase the total amount of the nonradioactive isotope atom above the total amount found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount. The ratio(s) of the at least two nonradioactive isotopes in the manufactured composition, material or device are measurably different than the ratio(s) found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount.

Embodiments of the invention can sample particulates, aerosols, vapors, and/or biological components of ambient air utilizing spherical air-sampling filters. Components of the embodiments may include a storage magazine for holding a plurality of spherical air-sampling filters, an air-sampling manifold configured to deliver an air-sampling filter from the storage magazine to a sampling location, and an air compressor to perform an air sampling operation and to transport a used air-sampling filter away from the sampling location. Operation of some embodiments may begin by rotating a slotted drum within the air-sampling manifold to deliver an air-sampling filter from the storage magazine to the sampling position. Operation may continue by using the air compressor to draw air from an ambient environment through the air-sampling filter. After sampling is complete, the air compressor may be utilized to pneumatically transport the used air-sampling filter away from the sampling position to a filter retrieval location via a transport tube. These operations can be pre-programmed locally or triggered by remote communication. Operation may continue uninterrupted due to a plurality of unused air-sampling filters retained in the storage manifold. Because operations can be triggered remotely and air samples are autonomously transported off site, embodiments of this invention eliminate unnecessary risks to human health created by other air-sampling devices, which require an operator to be present at a potentially hazardous sampling site to activate the device or retrieve air samples. Embodiments of the invention can be installed pre-emptively to eliminate risks to human health created when an operator must deliver a portable air-sampling device to a potentially contaminated sampling site. Furthermore, embodiments of the invention allow rapid retrieval of air samples following sample collection, which can expedite analysis and identification of aerosols and consequently help minimize human exposure to potentially dangerous and life-threatening chemical and biological contaminants.

Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

A computer-implemented method includes receiving a first input associated with an incident location of an incident. A second input associated with a measurement zone surrounding the incident location is received. The method further includes producing, via a display monitor, a set of waypoints associated with a flight path of an unmanned aerial vehicle (UAV) based on the first input and the second input. The set of waypoints is displayed on a satellite aerial map including the incident location.

Disclosed is a method for determining .sup.224Ra in a sediment by using a pulse ionization chamber emanometer, which belongs to the technical field of analysis and measurement. A pulse ionization chamber emanometer (PIC), a new emanometer, is used. Based on the half-life characteristics of different radon isotopes, one can separate the .sup.220Rn activity from the total counts by dual counting. The resulting .sup.220Rn measurement then can be used to determine the .sup.224Ra activity in sediment according to the principle of secular radioactive equilibrium.