This nest comprises a plurality of breakable connecting bridges, a plurality of flanges arranged in a predetermined pattern and configured to form the flanges of the medical containers, the flanges being connected to the breakable connecting bridges, and a supporting structure attached to the breakable connecting bridges so as to support the flanges. The flanges are integrally formed with the breakable connecting bridges and the supporting structure.

A device is provided that accommodates elongate receptacles and charges. The device includes a superior surface, a first positioning device, a detaining device, and either a pusher or a second positioning device. The first positioning device is adapted and arranged to accommodate a pairing of a charge and a corresponding elongate receptacle. The pusher is moveable along a direction towards the superior surface to introduce the charge into the elongate receptacle. The second positioning device accommodates the pusher with the second positioning device and the pusher being moveable along the direction towards the superior surface to introduce the charge into the elongate receptacle. The detaining device limits the extent of movement of the pusher towards the superior surface.

The invention relates to a closing apparatus for closing pharmaceutical containers, having a closing tool for joining a closure element to a pharmaceutical container (68), having a fluid unit for applying at least one gaseous fluid to the container, the fluid unit having at least one filter (64, 66), wherein the closing apparatus has a tool receptacle (14) and a tool unit (18), wherein the tool unit (18) is designed as a module which is repeatedly detachable from and connectible to the tool receptacle (14) by means of a coupling device (16) and which comprises the closing tool, the fluid unit and the at least one filter (64, 66).

A device for placing threaded lids on containers includes a holder for lids to be placed and a mechanism for retaining the lids stored in the holder. The retaining mechanism has a predetermined retaining position in which the lids stored in the holder are retained and a release position in which one of the lids stored in the holder is dispensed. The device also includes a lid positioner, which places a threaded lid on a container through a first rotation about a first axis when the positioner is in the placing position. When the position is in the receiving position, the positioner causes the retaining mechanism to change from the predetermined retaining position to the release position through rotation about the first axis.

A method for producing sterile solution product bags includes positioning a manifold assembly onto a filling machine. The manifold assembly includes a plurality of bags, a first filter, and a connection line in fluid communication with the first filter. Each of the plurality of bags includes a bladder and a stem in fluid communication with the bladder and with the connection line. The method includes activating a pump and at least partially filling one or more of the bladders by pumping fluid through the feed line, the first filter, and the connection line. The method includes sealing the stem of each of the filled product bags at a location between the connection line and the bladder, thereby creating one or more at least partially filled and sealed product bags. The method includes separating each of the at least partially filled and sealed product bags from the connection line.

An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck defining an opening that provides fluid communication with the interior; a cap assembly including a funnel having a first portion and a second portion, where the second portion extends radially outward from the first portion to form a floor on an interior thereof and a shoulder on an exterior thereof, the first portion defining a first bore and the second portion defining a second bore fluidly connected to the first bore; a self serum stopper having a self sealing membrane that extends radially outward to overlie at least a portion of the floor of the funnel; and a cap having a cap wall sized to fit over the funnel and a cover portion extending radially inward from the cap wall.

A machine for the preparation of medical product includes a device for loading bags of medical product into the machine. The device includes a shaft with the ability to rotate and two or more adaptors for housing injection points of bags of medical product arranged on the shaft. The rotation of the shaft causes the adaptors arranged on the shaft to rotate. Two stops define a position for loading bags by an operator and an operating position of the machine.

A machine is for the preparation of medical product. The machine includes a worktop for receiving containers. The worktop includes a series of holes for the introduction into each of them of an injection point belonging to a medical container to be filled. The holes give access to an interior of the machine, so that the injection points of the medical containers remain inside for their filling by the machine. The machine includes a removable device for loading medical containers into the machine. The removable device includes housings for the medical containers and detachable fasteners to the worktop of the machine.

Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.

A device (10) for handling closures (12) inside a clean room, in particular in a sterile environment, a clean room with a corresponding device (10) and a method for handling closures (12) within a clean room, in particular in a sterile environment, are proposed.