An isolator system for filling a container with a liquid, the isolator system comprises a filling module having a filling station for filling the container with the liquid, a stopper placing station for placing a stopper on the filled container, and a plurality of handling devices for handling the container within the filling module; a first transfer station for transferring the container to be filled into the filling module; a second transfer station for transferring the filled container out of the filling module; and a control device. The present application also discloses a transfer station for transferring a container and several methods.

An apparatus for securing a cap on a cylindrical container includes: a stage including a receiving region for separately receiving a cap and a container; and an elevator movable upwardly away from the stage and downwardly toward the stage. The elevator includes: a carrier disposed over the stage; a capturing member on the carrier and configured to capture the cap; and at least one extendable member extending from the carrier, the at least one extendable member movable from a home position with the extendable member above a center of the cap and an engagement position with the extendable member engaging the center of the cap and urging the center of the cap downwardly relative to an outer sidewall of the cap.

A clamping device is applied to a cover of a container and comprises a first gear plate having a first rail hole, a second gear plate having a second rail hole, a guiding plate configured between the first gear plate and the second gear plate and having a guiding slot, a first motor, a second motor and a clamp assembly. The first motor is configured to drive the first gear plate to rotate. The second motor is configured to drive the second gear plate to rotate. The clamp component of the clamp assembly is disposed in the first rail hole, the second rail hole and the guiding slot and configured to contact the cover. The first motor and the second motor drive the first gear plate and the second gear plate to rotate in opposite directions and drive the clamp component to move inwardly for clamping the cover.

A cartridge set including: a plurality of cartridges; a plurality of holders, each of which has an upper end externally fitted to the outer peripheral surface of each of the cartridges, and has a lower end face whose outer diameter is greater than the outer diameter of the outer peripheral surface of the cartridge; a supporting plate that has a plurality of through-holes, each of which has an inner diameter greater than the outer diameter of the outer peripheral surface of the cartridge and has each of the plurality of cartridges inserted therethrough; a storage box that stores the supporting plate therein; and a lid member that blocks an upper end opening of the storage box.

A reconfigurable nest handling system for handling nests of objects arranged in a predetermined pattern is presented and applied to a system for filling nested pharmaceutical containers with a pharmaceutical fluid. In one general aspect, the system comprises a sterilizable chamber containing a planar rotary stage with tub and nest positioning systems that may be reconfigurable for holding differently sized pharmaceutical container tubs and nests and pharmaceutical closure tubs and nests. The chamber has a rotatable cover removal station, a rotatable filling station with a dispenser head, and camera guided vacuum pickup facilities for handling container and closure nests. The vacuum pickup facilities may be reconfigurable for handling differently sized nests. An associated method for filling the containers comprises establishing an aseptic condition within the chamber; removing covers from a container tub and a container closure tub by operating both the rotary stage and the cover removal station. The vacuum pickup facility transfers into the fiducial locating structure a container nest bearing pharmaceutical containers. The fluid is dispensed into the containers by operating both the rotary stage and the filling station. A container closure nest is placed on the container nest in the fiducial locating structure with closures in correspondence with containers. A ram in the chamber forces the closures into the containers.

A magazine for use with an apparatus for filling capsules with at least one product, the magazine including a body, a first row of openings provided on a top portion of the body, a plurality of first passages extending parallel with a longitudinal axis of the body to a bottom portion of the body, one first passage in communication with each of the openings in the first row of openings, a second row of openings provided parallel to the first row of openings on the top portion of the body, and a plurality of second passages extending at an angle relative to the longitudinal axis of the body and through the body to the bottom portion of the body, one second passage in communication with each of the openings of the second row of openings.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

The invention provides novel apparatus and methods for efficiently and accurately filling vials with gaseous materials such as a fluorinated gas, with or without concomitantly filling the vials with another liquid or solid material.

A container and method for filling same. The container includes a penetrable and resealable portion that is resealable, and a container body having a sealed empty chamber in fluid communication with the penetrable and resealable portion for receiving therein a substance. The resealable member may be dome-shaped or have a convex outer surface. A method of filling the container includes penetrating the penetrable and resealable portion with an injection member and introducing a substance into the chamber, withdrawing the injection member, and resealing the penetration hole in the resealable member made by the injection member during penetration.

Described herein are ready to use, non-aqueous pharmaceutical compositions comprising 5-aza-2-deoxycitidine and at least one aprotic solvent. The pharmaceutical compositions may further comprise at least one protic solvent. Also described are processes for preparing the pharmaceutical compositions and their use for the treatment of patients suffering from myelodysplastic syndromes.