Disclosed in the present invention is a system for forming a product package by online forming, filling and sealing, the system comprising: a sterilization apparatus, a forming apparatus, a conveyor belt, a filling apparatus and a first closing apparatus. Also disclosed is a method for forming a product package by online forming, filling and sealing. The method of the present invention integrates production and filling of large-volume packages, greatly shortening the supply chain and increasing production efficiency.

In combination a spouted pouch to be filled with a flowable product by a filling machine, a plug, and a cap. The interference fit plug is releasably mounted over the top end of the neck of the spout body and hermetically seals the product passage of the spout body. The plug is adapted to be removed by the filling machine and to be replaced by pressing the plug onto the neck after filling of the pouch. The plug removal, filling, and replacing of the plug are preferably performed in an aseptic environment. The cap is after the filling of the pouch and the replacing of the plug onto the neck. The capping is preferably performed by a capping machine in a non-aseptic environment.

Disclosed herein is a fluid transfer assembly for dispensing flowable material from a container, the fluid transfer assembly having a spout, a screw cap body, and an aseptic plug, wherein the aseptic plug is configured to form an aseptic seal with the screw cap body.

Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

Disclosed herein is a fluid transfer assembly for dispensing flowable material from a container, the fluid transfer assembly having a spout, a screw cap body, and an aseptic plug, wherein the aseptic plug is configured to form an aseptic seal with the screw cap body.

The invention relates to a nozzle for inflating a spout film bag, the lateral surface of which nozzle is designed in such a way that the nozzle can be inserted at least partially into the spout of the spout film bag and also at least partially into the interior of the spout film bag, wherein the lateral surface of the part of the nozzle that can be inserted has a bulging design. The invention further relates to a method for inflating a spout film bag by using said nozzle, comprising the following steps: providing the nozzle; inserting the nozzle into the spout of the spout film bag and lowering the nozzle in the spout to a first position; after the first position has been reached, wherein the lateral surface of the inserted nozzle interacts with the internal form of the spout in such a way that the interior of the spout film bag is substantially sealed, introducing flushing or inflating air into the interior of the spout film bag by means of the nozzle.

Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

In combination a spouted pouch (1) to be filled with a flowable product by a filling machine, a plug (50), and a cap (70). The interference fit plug is releasably mounted over the top end of the neck of the spout body and hermetically seals the product passage of the spout body. The plug is adapted to be removed by the filling machine and to be replaced by pressing the plug onto the neck after filling of the pouch. The plug removal, filling, and replacing of the plug are preferably performed in an aseptic environment. The cap is after the filling of the pouch and the replacing of the plug onto the neck. The capping is preferably performed by a capping machine in a non-aseptic environment.

An apparatus includes a hopper, having a vent for articles, for storing articles; an arm connected to the vent of the hopper, for moving the position of the vent along with rotation around a rotating shaft, one end portion of the arm as an elongated member being connected to the rotating shaft extending in a horizontal direction; and a bag attachment portion including a bag support portion for supporting a bag into which articles are loaded, an attachment structure body for attaching an opening portion of the bag and a movable member for moving freely to a condition where the bag support portion is positioned at an appropriate inclined angle with respect to a horizontal direction. The vent of the hopper is adjustable to be positioned above the position of the opening portion of the bag supported when the arm and the bag attachment portion are moved.