Described herein is a holding basket (100) for containing an inner basket (200) for holding at least one medical item for processing having a top end (102) and a base end (104) comprising: an essentially rectangular base (110) and side walls (120, 122, 124) extending from the base (110), two rims (130, 132) each disposed on a first pair (120, 122) of opposing side walls, two windows 140) each disposed on a second pair opposing side walls (124) configured for manual access for slidable removal of the inner basket (200), wherein the holding basket (100) is configured for stackability or nestability with an adjacent holding basket (100′, 100″).

A pharmaceutical order processing system, components thereof, and associated methods for filling a prescription order. The pharmaceutical order processing system includes a lower insert placer, a syringe placer, a dosing cup placer, a pharmaceutical container placer, and/or an upper insert placer. The lower insert placer places a lower insert into a box. The syringe placer places a syringe into a syringe compartment of the lower insert. The dosing cup placer places a dosing cup into a dosing cup compartment of the lower insert. The pharmaceutical container placer places a pharmaceutical container into a pharmaceutical container compartment of the lower insert. The upper insert placer places an upper insert into the box after the box has received the lower insert and the lower insert has received the syringe, the dosing cup and the pharmaceutical container.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

The present invention relates to a beta-component of a transfer system for a sterile isolation region, a sterile isolation region, an aseptic filling system, and a method of operating such a filling system.

An aseptic chamber of a package producing machine is provided. The aseptic chamber comprises an entry section for allowing a web of packaging material to enter the aseptic chamber, and at least one electron beam emitter arranged downstream the entry section for treating the web of packaging material it runs through the aseptic chamber. The entry section comprises an entry chamber arranged between an infeed gasket and an inner gasket.

Methods of manufacturing shelf stable pods containing food or drink to be rapidly cooled, include inserting a mixing paddle into an aluminum can through an open end of a body of the can and sterilizing the can and mixing paddle at temperatures below a stress relief temperature of the can in a first aseptic chamber. The method also includes filling the can with a sterilized food or drink in the aseptic chamber, sealing a sterilized base of the can to the open end of the body of the can with a food-safe adhesive to create a hermetic seal, removing the can from the first aseptic chamber while maintaining the hermetic seal outside the first aseptic chamber, and mechanically seaming the base to the can.

Method and apparatus for eliminating oxygen in the filling of a flexible bag with a beverage utilizing sources of inert gas, vacuum, and beverage. A filling head regulates the injection of inert gas and applies a vacuum to the flexible bag the bag spout. The bag spout is separately rinsed of oxygen prior to recapping the same on the flexible bag.

A method of manufacturing a spouted pouch aseptically filled with contents includes a supplying process, a sterilizing process, a stopper opening process, a filling process, a tightly re-stopping process, and a capping process. The sterilizing process, the stopper opening process, the filling process, and the tightly re-stopping process are performed in an aseptic chamber.

A machine for filling and closing pharmaceutical containers disposed in respective supports has a sterile first work environment with an inlet passage and an outlet passage, a conveyor transporting the supports, which crosses the work environment through the inlet passage and the outlet passage, and a collecting station in the work environment, for collecting and extracting the containers from the supports. The work environment has a second outlet passage. A sterile second work environment has an inlet and an outlet, the inlet being at the second outlet passage of the first work environment to define a common passage. Another conveyor passes through the common passage, has a first part in the first work environment and a second part in the second work environment, and is predisposed so that the first part can receive the containers and convey them through the common passage at a filling station and a closing station.

Nonwoven fabrics are provided that include at least a first nonwoven layer. The first nonwoven layer includes multi-component fibers densely arranged and compacted against one another. The multi-component fibers comprise at least a first component comprising a first polymeric material including a first polyolefin and a second component comprising a second polymeric material including a second polyolefin, in which the first polymeric material is different than the second polymeric material. The first polymeric material, the second polymeric material, or both include a compatibilizer comprising a copolymer having a comonomer content including (i) at least 10% by weight of the compatibilizer of a first monomer corresponding to the first polyolefin and (ii) at least 10% by weight of the compatibilizer of a second monomer corresponding to the second polyolefin.