Described and depicted is a method for filling packages that are open on one side, in particular cardboard composite packages, with free-flowing products, in particular foodstuffs, in a filling machine. In order to allow the heating, sterilisation and/or drying to be carried out at high throughputs more reliably and with less complexity in terms of the equipment and/or method, it is provided that preheating air and/or drying air and/or sterilising agent is introduced into the packages that are open on one side and that a volume of preheating air and/or drying air and/or sterilising agent, said volume corresponding to at least three times the volume of the package that is open on one side, is introduced into at least one, preferably at least substantially each, package that is open on one side.

Described and depicted is a method for filling packages that are open on one side, in particular cardboard composite packages, with free-flowing products, in particular foodstuffs, in a filling machine. In order to allow the heating, sterilisation and/or drying to be carried out at high throughputs more reliably and with less complexity in terms of the equipment and/or method, it is provided that preheating air and/or drying air and/or sterilising agent is introduced into the packages that are open on one side and that a volume of preheating air and/or drying air and/or sterilising agent, said volume corresponding to at least three times the volume of the package that is open on one side, is introduced into at least one, preferably at least substantially each, package that is open on one side.

An apparatus for the production and filling of food containers includes at least one device for forming a sheet made of polymeric material to provide accommodation receptacles which have at least one access opening, at least one filling unit adapted to fill, through the access opening, the accommodation receptacles with at least one type of food, and at least one sealing unit to seal the access opening with a closure film. The apparatus includes at least one device for removing portions, and at least one laser emitter for providing a weakening portion at a respective connecting edge between adjacent accommodation receptacles. The polymeric material is chosen from: polyethylene terephthalate and polypropylene and copolymers thereof.

The apparatus includes a first section which accommodates the filling unit, the sealing unit, and the device for removing portions, and a second section, separate from the first section, which accommodates the laser emitter.

The present disclosure provides novel processes for providing sterile, pre-filled syringes or injection devices for pharmaceutical compositions, including protein and biopharmaceutical formulations. In some examples, secondary packaging is performed in an aseptic environment, which removes the need for any terminal sterilization method. In some examples, the aseptic packaging method results in a sterile injection device suitable for use in ophthalmic injections.

To sterilize a sterilization filter unit with heated steam, minimize the heat load on the sterilization filter unit and extend the service life of the sterilization filter unit.

Heated steam is supplied to a sterilization filter unit that sterilizes supplied air, the temperature of the heated steam discharged from the sterilization filter unit is measured at predetermined time intervals, the F value is calculated from the measured temperature, and sterilization of the sterilization filter unit is ended when the F value reaches a target value.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

The present invention relates to a method for enabling hospitals or clinics to administer a dose of a drug to patients in need thereof while avoiding steps of manipulation, dilution, reconstitution, dispensing, sterilization, transfer, handling or compounding before intravenous administration. The present invention further relates to a perfusion system comprising different sets of perfusion containers, each container comprising a ready-to-infuse, stable, sterile, aqueous perfusion solution of a drug, wherein the set of perfusion containers alone or in combination provides for direct intravenous administration of a desired dose of the drug to a patient in need thereof, such that the delivered dose is equal to or within ±5% of the calculated dose.

The present invention relates to a method for enabling hospitals or clinics to administer a dose of a drug to patients in need thereof while avoiding steps of manipulation, dilution, reconstitution, dispensing, sterilization, transfer, handling or compounding before intravenous administration. The present invention further relates to a perfusion system comprising different sets of perfusion containers, each container comprising a ready-to-infuse, stable, sterile, aqueous perfusion solution of a drug, wherein the set of perfusion containers alone or in combination provides for direct intravenous administration of a desired dose of the drug to a patient in need thereof, such that the delivered dose is equal to or within ±5% of the calculated dose.

The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.

The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.