Disclosed is a container/applicator for content such as a cosmetic product. A container/applicator for content, having a cylindrical shape with an axis, that includes a reservoir having a wall, a closed end closed by a bottom and an open end with a free edge, a cap having a skirt and a top wall, and an applicator rod, a casing having a distal end and a proximal end, a squeegee, an interface, wherein the squeegee is a part separate from the casing and is housed in the casing, includes a protruding flange and a distal portion, is held by fixed rigid squeegee/reservoir-casing combination. The casing includes an open distal end, and a transverse step forming an inner shoulder.

A hermetically sealed thermoplastic container or ampoule having a hollow body portion, a neck portion, unitary with the body portion and terminating in a circumferential, inwardly extending sealing flange, and a removable cap. The neck portion defines an access passageway to the hollow body portion a portion of which is configured as a tapered female connector adapted to receive a tapered male connector when the access passageway is open. The outer surface of the neck portion can be provided with lugs for engaging a tapered male connector with a threaded collar.

A liquid applicator comprising an absorbent member, and a single-piece, unitary body. The body can include a closed container defining a reservoir, and a tab. The container can include a main portion, a transition portion, a rib, and a chamber located in the tab and coupled to the transition portion via a frangible connection. The main portion, the transition portion, the rib, and the chamber can each define a portion of the reservoir, and at least the main portion, the transition portion, and the rib can have a uniform wall thickness. The tab can include the chamber and can be coupled to the transition portion at least by the frangible connection, the tab being movable with respect to the transition portion between a first position in which the frangible connection is intact and a second position in which the frangible connection is fractured.

In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

A method of controlling a temperature of a biopharmaceutical product during blow-fill sealing, includes developing a model based on heat transfer mechanisms that incorporates the effects of the blow-fill sealing on the biopharmaceutical product, providing a parison to a blow-fill sealing machine for accepting the biopharmaceutical product during the blow-fill sealing, predicting a temperature of at least one the biopharmaceutical product, the parison, and a component of the blow-fill sealing machine at a stage in the blow-fill sealing, and adjusting a parameter of the blow-fill sealing machine to reduce damage to the biopharmaceutical product.

A container, in particular a plastic ampoule produced using a blow molding process, and filled and closed in the production mold, has a sleeve-shaped neck part (4) connected to a container body (2) as an axial extension. The neck part forms a seat (6) for a preformed insert (8) extending along the axis (12) of the neck part (4), and is formed in the production mold, on a peripheral region (14) of the insert (8). At least one sealing element (42; 68) is provided on the insert (8). The sealing element forms a seal in a sealing region surrounding the axis (12), in combination with a contact surface (38) formed on the seat (6) of the neck part (4).

An ampoule for a medical liquid comprises an ampoule body for accommodating a medical liquid and a connection part for connecting a removal device to the ampoule, which connection part extends in a longitudinal extension direction and adjoins the ampoule body. The connection part and the ampoule body are formed as one piece and the connection part has a threaded segment having at least two thread turns arranged thereon, which are axially offset from each other in the longitudinal extension direction. The ampoule enables simple attachment of a removal device, creates a tight transition between a connection part and the removal device, is simple and economical to produce, and can provide a defined attachment state for the removal device on the ampoule.

The container (1) for fluid products, particularly for medical products, pharmaceuticals, cosmetics, food or the like, comprises: a hollow body (2) for the containment of a fluid product having a neck (3); a closing element (8) having an attachment portion (9) which, in a closing configuration, is associated with the hollow body (2) along a preset breaking line (10) adapted to allow the separation of the closing element (8) from the hollow body (2) in a separation configuration wherein on the hollow body (2) is formed an opening for the outflow of the fluid product; at least a flap element (11) for supporting information, data or logos (12), joined to the attachment portion (9) and movable between an initial configuration wherein the flap element (11) is moved away from the neck (3), and a final configuration wherein the flap element (11) is fitted at least partially around the neck (3) to form a maneuver key (13) adapted to allow the removal by tearing the closing element (8) off.

An integrated at least two component mixing and delivery system and method for creating a new mixture from a first component contained within a first enclosure and a second component contained within a second enclosure that is contained within the first enclosure and, via a series of operations that mix the two components and enable the application of through an applicator tip the placement of the new mixture on at least one surface or a portion thereof.

The present invention relates to a two-part plastic blank set for the production of a drug applicator for storing a unit dose of a drug preparation and for administering that unit dose into the human nose.