In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

In one general aspect, a method is disclosed for processing a pharmaceutical substance in a pharmaceutical processing system that includes lyophilizing a plurality of containers provided in a nest. A first controlled environment enclosure in the pharmaceutical processing system is isolated against an external environment, and a controlled environmental condition is established in the first controlled environment enclosure. The pharmaceutical substance is deposited into at least a portion of the plurality of containers in the first container nest at a filling station within the first controlled environment enclosure. The deposited pharmaceutical substance is lyophilized in the first container nest.

In one general aspect, a method is disclosed for processing a pharmaceutical substance in a pharmaceutical processing system that includes lyophilizing a plurality of containers provided in a nest. A first controlled environment enclosure in the pharmaceutical processing system is isolated against an external environment, and a controlled environmental condition is established in the first controlled environment enclosure. The pharmaceutical substance is deposited into at least a portion of the plurality of containers in the first container nest at a filling station within the first controlled environment enclosure. The deposited pharmaceutical substance is lyophilized in the first container nest.

A member coupling mechanism capable of coupling two members using a necessary tightening force even in a limited space by a small and simple configuration. A member coupling mechanism includes a first member including a member coupling portion having an open apical surface, a second member coupled to the member coupling portion of the first member, an elastic sealing member inserted between the first member and the second member to seal an opening of the apical surface of the member coupling portion, a coupling member that couples the first member and the second member together, and an acting portion that exerts a force on the coupling member.

A member coupling mechanism capable of coupling two members using a necessary tightening force even in a limited space by a small and simple configuration. A member coupling mechanism includes a first member including a member coupling portion having an open apical surface, a second member coupled to the member coupling portion of the first member, an elastic sealing member inserted between the first member and the second member to seal an opening of the apical surface of the member coupling portion, a coupling member that couples the first member and the second member together, and an acting portion that exerts a force on the coupling member.

A closure device for a container opening includes a lid element for closing the container opening, a chamber which is arranged on the lid element, and an inner housing. The chamber and the inner housing have corresponding closure means and opening means as well as corresponding first threaded means. A discharge opening paired with the chamber can be released with the aid of the threaded means by moving the lid element relative to the inner housing such that a medium stored in the chamber can exit into the container. The chamber has a first region above the first threaded means and a second region below the first region, wherein, relative to an axis of rotation of the thread, the first region is designed radially greater than the second region.

A closure device for a container opening includes a lid element for closing the container opening, a chamber which is arranged on the lid element, and an inner housing. The chamber and the inner housing have corresponding closure means and opening means as well as corresponding first threaded means. A discharge opening paired with the chamber can be released with the aid of the threaded means by moving the lid element relative to the inner housing such that a medium stored in the chamber can exit into the container. The chamber has a first region above the first threaded means and a second region below the first region, wherein, relative to an axis of rotation of the thread, the first region is designed radially greater than the second region.

The invention relates to a capsule (1) for a flanged cork stopper, the capsule (1) having a body (2) comprising a top (3) and a cavity (4) inside which at least two anti-rotation splines (5) are arranged, and the capsule further comprising an axial retention chamber (6) disposed within said cavity (4), wherein retention chamber (6) is shaped to receive and axially retain a flange of a flanged cork stopper. The invention also relates to a capsulated stopper comprising a flanged stopper, the flange of which is attached to the capsule (1) of the invention. The invention further relates to the production process of said capsulated stopper.

The ink adhesion surface sides of the plug member removed from the ink jet recording apparatus and the cap removed from the ink replenishment container are faced each other, superposed and attached so that the ink adhesion surfaces are not exposed to the outside.

The ink adhesion surface sides of the plug member removed from the ink jet recording apparatus and the cap removed from the ink replenishment container are faced each other, superposed and attached so that the ink adhesion surfaces are not exposed to the outside.