Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.

A column packing material for supercritical fluid chromatography which allows good peak shape to be obtained in the analysis of free fatty acids, etc. and in the analysis of agricultural chemicals, etc., and has excellent durability for repeated analysis. The column packing material for supercritical fluid chromatography includes polymer particles containing cross-linked polymer, the degree of swelling of which after absorbing tetrahydrofuran and the degree of swelling of which after absorbing methanol are both 1.4 or less.

A column packing material for supercritical fluid chromatography which allows good peak shape to be obtained in the analysis of free fatty acids, etc. and in the analysis of agricultural chemicals, etc., and has excellent durability for repeated analysis. The column packing material for supercritical fluid chromatography includes polymer particles containing cross-linked polymer, the degree of swelling of which after absorbing tetrahydrofuran and the degree of swelling of which after absorbing methanol are both 1.4 or less.

The invention relates to a method of chromatography wherein a gaseous, liquid or supercritical fluid mobile phase, which contains substances to be separated, flows through a porous packing which comprises a plurality of capillary channels which extend in the direction of flow of said mobile phase, said packing being manufactured by a method wherein: a bundle of elementary fibres is assembled, said fibres comprising a core made of a solid, liquid or gaseous material, and a shell made of a drawable material, said bundle is drawn in order to reduce the diameter of said fibres, a porous matrix is formed around the core of the drawn fibres, the formation of said porous matrix comprising a transformation of the shell material, where said porous matrix comprises at least one population of connected pores interconnecting the channels, where the thickness of the porous matrix between two adjacent channels is less than the diameter of the channels, preferably less than half the diameter of the channels, where necessary the core material is removed so as to leave free channels in the porous matrix.

The invention relates to a method of chromatography wherein a gaseous, liquid or supercritical fluid mobile phase, which contains substances to be separated, flows through a porous packing which comprises a plurality of capillary channels which extend in the direction of flow of said mobile phase, said packing being manufactured by a method wherein: a bundle of elementary fibres is assembled, said fibres comprising a core made of a solid, liquid or gaseous material, and a shell made of a drawable material, said bundle is drawn in order to reduce the diameter of said fibres, a porous matrix is formed around the core of the drawn fibres, the formation of said porous matrix comprising a transformation of the shell material, where said porous matrix comprises at least one population of connected pores interconnecting the channels, where the thickness of the porous matrix between two adjacent channels is less than the diameter of the channels, preferably less than half the diameter of the channels, where necessary the core material is removed so as to leave free channels in the porous matrix.

A fluid supply device for a fluid chromatograph includes a storage container, a pump device, a filter, a guide and a heat dissipation device. The pump device supplies a mobile phase to a column. The storage container stores the pump device and the filter and has an intake port. The guide guides gas that has been introduced into the storage container through the intake port to the filter. A heat dissipation device dissipates heat generated from the pump device to the outside of the storage container together with the gas inside of the storage container. The storage container includes a door having a front surface directed forwardly of the fluid supply device. The intake port is provided at the door to be directed sidewardly of the fluid supply device.

A supercritical fluid chromatograph includes a liquid sender that supplies a mobile phase including a supercritical fluid to a supply flow path, first and second back pressure regulators that are respectively provided in first and second flow paths into which a path from the liquid sender branches and an analysis column provided at a position farther upstream than the first back pressure regulator in the first flow path. An analysis assistance device that assists determination of an analysis condition of the supercritical fluid chromatograph includes a storage that stores a relationship between a sample introduction ratio representing a ratio of an amount of a sample to be introduced into the first flow path with respect to an amount of a sample to be introduced into the second flow path, and a differential pressure between the first and second back pressure regulators as a first relationship, a receiver that receives one value of a value of the sample introduction ratio and a value of the differential pressure, a first calculator that calculates the other value of the sample introduction ratio and the differential pressure from the one received value based on the first relationship and a presenter that presents the calculated value.

A gas-liquid separator according to an embodiment of the present invention separates a mobile phase containing a gas and a liquid into a gas and a liquid. The gas-liquid separator according to the embodiment of the present invention includes an introduction flow channel to which a mobile phase is introduced, and a plurality of discharge flow channels connected to the introduction flow channel. A gas and a liquid are discharged from a discharge port of the discharge flow channel.

A preparative closed cycle supercritical fluid column chromatography system, device, and method of isolating high volumes of pure components from mixtures using a supercritical solvent. Bulk fractions of desirable material from plants can be obtained using supercritical fluid column chromatography with a chromatography column. A chemical sensor downstream the chromatography column detects chemical species eluted from the column and a plurality of collection columns collects the bulk fractions of product with a control system controlling the collection valves based on detection of chemical species at the chemical sensor.

A preparative closed cycle supercritical fluid column chromatography system, device, and method of isolating high volumes of pure components from mixtures using a supercritical solvent. Bulk fractions of desirable material from plants can be obtained using supercritical fluid column chromatography with a chromatography column. A chemical sensor downstream the chromatography column detects chemical species eluted from the column and a plurality of collection columns collects the bulk fractions of product with a control system controlling the collection valves based on detection of chemical species at the chemical sensor.