A system for TFF filtration of a feedstock includes a feed vessel containing a solution comprising a target biomolecule, a filter membrane for filtering the solution, a feed pump for moving the solution from the feed vessel to the filter membrane, a buffer vessel coupled to the feed vessel by a buffer supply line, and a diafiltration pump disposed in the buffer supply line for delivering a buffer solution to the feed vessel. A variable path-length instrument is coupled to the feed line for determining, in real time, a concentration of the target biomolecule in the solution. A controller is coupled to the variable path-length instrument, the feed pump, and the diafiltration pump to control operation of the system based on the received information.

The invention relates to preventing microplastics from the entering the environment. In particular the invention is directed to regenerating the efficiency of filters for removing microfibers from washing machine waste water, as well as waste from other appliances and other sources of effluent with entrained microplastics. A separator is therefore provided for separating microplastics from waste water comprising a chamber with an inlet and an outlet, at least one sieve structure forming a permeable barrier between the inlet and the outlet and a wash apparatus for washing the sieve structure.

The invention relates to preventing microplastics from the entering the environment. In particular the invention is directed to filtering microfibers from the waste water from washing machines as well as waste from other appliances and other sources of effluent with entrained microplastics or other microp-ollutants. A separator is provided for separating microplastics from effluent comprising; a chamber including at least one sieve structure, a shroud that acts as a vortex finder and a baffle coaxial with the shroud and projecting upwards from the lower end of the chamber, wherein the shroud has a circular lower rim and the baffle has a circular upper rim, wherein the radius of the lower rim of the shroud is greater than the radius of the upper rim of the baffle.

Aircraft fuel ice capturing filter device housings, aircraft fuel ice capturing filter devices, and methods of use are provided.

A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.

A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

A filter device for removing particles from a fluid includes a fluid chamber and an inlet for fluid, an outlet for filtered fluid and an outlet for particles, each coupled to the fluid chamber. The filter device also includes a flow directing mechanism for inducing a vortex flow around a vortex axis in the fluid chamber. The outlet for particles is coupled to the fluid chamber at a location substantially perpendicular to the vortex axis.

Disclosed is a filtering system used in any pool filtrations, filtration of taps or building entrance hot and cold use water, filtration of city water before osmosis filtering devices, filtration of heating and cooling mechanical plant systems, and filtration of cooling water in hydro-electric power plants. The system provides for forming a vortex inside a filter by directing and increasing speed of filtered liquid and thus providing decreasing pressure on the filter surface and collection of filtered particulates in a particulate accumulation chamber. The system also provides for automatic cleaning of the filter by reverse flushing, without the need for dismantling, by differential pressure sensors based on rate of contamination.

Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.