An inline-type strainer including a drain line and a screen configured to be attachable to and detachable from a housing is provided. A screen is supported to be attachable to and detachable from a lid. A lid coupling mechanism that couples a housing and the lid when the lid is attached to the housing is provided between a bottom surface of the housing facing the filter chamber and a lower end of the lid. A lower discharge flow path is formed in a lower coupling element on a side close to the housing constituting the lid coupling mechanism, and an upper discharge flow path is formed in the upper coupling element on a side close to the lid constituting the lid coupling mechanism. When the lid is attached to the housing, a coupling state is established between the upper and lower coupling elements, and the upper and lower discharge flow paths communicate with each other, and thus a drain line is constructed.

A liquid is made to flow into a filter case from a tangential direction at any point on a side surface of the filter case and produces a swirling flow. Bubbles collected in a center of the swirling flow are retained by a retainer plate, thereby removing the bubbles from the liquid. A filter element filters the liquid from which the bubbles were removed.

Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion a the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

A self-clearing filter for filtering a fluid, the self-clearing filter comprising a filter wall having a lumenous side and an external side and a pump for creating a flux of the fluid to impinge against the external side of the filter wall. Methods for filtering a fluid by diverting a portion of the fluid flux to impinge against the filter.

A self-clearing filter for filtering a fluid, the self-clearing filter comprising a filter wall having a lumenous side and an external side and a pump for creating a flux of the fluid to impinge against the external side of the filter wall. Methods for filtering a fluid by diverting a portion of the fluid flux to impinge against the filter.

A liquid filter has an outer housing and a filter drum. The outer housing has an outer wall and a pair of end walls that are positioned on opposed sides of the outer wall. The outer housing has an inlet and at least one outlet. The filter drum has a side wall, a first end wall and a second end wall. The first end wall and the second end wall are positioned on opposed sides of the side wall. The filter drum is secured within the outer housing. The filter drum has a t least one filter fastened in at least one of the first end wall and the second end wall to allow liquid to flow from an exterior of the filter drum to an interior of the filter drum. The inlet is positioned on the outer housing such that liquid is fed tangentially in relation to the filter drum through the inlet to create a centrifugal force within the outer housing causing solid particles to be forced towards the outer wall of the outer housing. The filter drum has at least one outlet pipe in fluid communication with the interior of the filter drum and the at least one outlet of the outer housing through which filtered liquid may pass.

An air vent hole includes a substantially columnar hole main body portion, a first hole portion formed on the upper side of the hole main body portion, and a second hole portion formed on the lower side of the hole main body portion. Each of the first hole portion and the second hole portion partly has, in a cross section of the hole portion substantially orthogonal to a first direction that is a longitudinal direction of the hole main body portion, a cross-sectional area smaller than a cross-sectional area of a cross section of the hole main body portion substantially orthogonal to the first direction. A float inserted into the air vent hole is movable between a position where the float occludes the first hole portion and a position where the float occludes the second hole portion. The float occludes the first hole portion under the weight of the float. However, the float is pushed up by air. Furthermore, the float is formed of a material having a smaller specific gravity than a liquid to be filtered. Thus, the float is pushed up by the liquid to occlude the first hole portion.