A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

When a liquid flows into a case along a tangential direction at an arbitrary point on a side surface of a filter case from an inflow pipe provided substantially around an outer periphery, at the side surface of the filter case, a swirling flow is produced in the liquid flowed and air contained in a fluid is collected in a center portion of the swirling flow to generate bubbles. The inflow pipe and a filter element are positioned not to overlap each other in a height direction, whereby the liquid flows into a hollow portion of a filter element from a case while swirling. The bubbles generated in the center portion of the swirling flow are released to a space above a liquid surface of the fluid retained in a tank through an air outlet portion formed in an upper end surface or the side surface of the filter case.

A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

According to an embodiment of the present disclosure, there is provided a hydro crusher for water treatment, for removing living organisms from water to be treated, the hydro crusher including: a body portion which has a cylindrical shape having an inner space, and includes an inflow portion to allow the water to be treated to be drawn into the inner space therethrough, and a discharge portion to discharge the water to be treated, drawn in through the inflow portion; and solid particles which are movable by the water to be treated, wherein the movable solid particles are filled in at least a portion of the inner space.

Accordingly, there is an effect that physical sterilization is possible by killing or inactivating living organism included in water to be treated by applying a shock to the living organism.

Disclosed herein is a filter having a housing having first and second end surfaces and interior and exterior surfaces, a membrane disposed within the tubular housing, a first end cap sealed to the first end surface of the tubular housing and the first end surface of the membrane; a second end cap sealed to the second end surface of the tubular housing and the second end surface of the membrane; and a fluid channel formed in the interior surface of the housing in a helical pattern. The helical pattern has a helical pitch in an axial direction of the housing of less than or equal to about 60 mm.

A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.

A separator device for removing particles from suspension in a liquid includes a housing having first and second chambers with apertures for ingress and egress of liquid into the first chamber. Means are provided for setting up a swirl of liquid within the first chamber. Apertures enable flow of liquid between the first chamber and the second chamber. Means are also provided for setting up a swirl of liquid within the second chamber. The swirl in the second chamber is in substantially the opposite direction to the swirl in the first chamber, and there is no substantial flow in the second chamber which is in the same direction as the swirl in the first chamber.

A separator device 10 for removing particles from suspension in a fluid including a housing 12, having first and second apertures 96 for ingress and egress of fluid into and out of the housing 12; a first separator chamber 38 disposed at one end of the housing; a second separator chamber 40 disposed at the other end of the housing, and a central chamber disposed between the first and second separator chambers 38, 40, the first and second separator chambers 38, 40 being apertured for ingress and egress of fluid from the central chamber and each containing obstruction means to slow the flow of fluid within the chamber.