A hollow fiber membrane module (100) of the present disclosure includes: a plurality of hollow fiber membranes (10); a binding portion (20) binding the plurality of hollow fiber membranes (10) at one end portions thereof; and a cap (30) having an internal space (30s) that communicates with each of the plurality of hollow fiber membranes (10), the cap (30) being integrated with the binding portion (20). Specifically, no other component is present between the binding portion (20) and the cap (30).

The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

An automatic operating device for hollow fiber membrane includes a first membrane fiber traction apparatus, a membrane fiber bracket member for fixing the membrane fiber, and a second fiber traction apparatus, which are disposed in sequence. The membrane fiber bracket member comprises a first membrane fiber bracket and a second membrane fiber bracket each having upper openings. The first membrane fiber traction apparatus, the first membrane fiber bracket, the second membrane fiber bracket, and the second membrane fiber traction apparatus are all provided with membrane fiber holes matched with the membrane fiber. The automatic operating device further comprises a membrane fiber grabbing mechanism, a first driving mechanism, a cutting mechanism and a glue-filling mechanism. The present invention can realize the automatic penetration of membrane fiber into the membrane fiber brackets and the traction apparatus, and realize formation of the membrane fiber in a regular arrangement.

A method for producing a membrane filter for filtering a liquid, wherein the membrane filter includes at least one header and at least one membrane block that is connected with the at least one header, wherein the at least one membrane block includes multiple rows of hollow fiber membranes arranged substantially parallel to one another, wherein each of the hollow fiber membranes includes an open end that connects to a permeate chamber in the at least one header and a filtrate is pullable from the permeate chamber during operation of the membrane filter, wherein the at least one membrane block includes a spacer at a distance from the open end, wherein the spacer connects the hollow fiber membranes with one another and keeps them apart, and wherein the hollow fiber membranes are enveloped by a seal layer between the spacer and the open end.

A hollow fiber membrane module includes: a tubular case; a hollow fiber membrane bundle; and a pair of sealing and fixing portions, in which an outside-membrane channel that passes by an outer wall of each of the hollow fiber membranes and an inside-membrane channel that passes through the hollow inside of each of the hollow fiber membranes are formed, moist air flows through the outside-membrane channel, and dry air flows through the inside-membrane channel, whereby moisture in the moist air is supplied to the dry air by a membrane separation effect of the hollow fiber membranes, wherein a plurality of spaces are disposed between the case inner wall and the hollow fiber membrane bundle, and a restriction portion that restricts the hollow fiber membrane from entering into the spaces is partially disposed between the hollow fiber membrane bundle and each of the spaces.

The present invention concerns a filtration membrane bundle (30) comprising a plurality of elongated filtration fibers (40) arranged in a spiraled coil (34); and one or more filaments (50) woven around the plurality of elongated filtration fibers (40) binding one or more adjacent elongated filtration fibers (40) at a predetermined and homogeneous spacing (44,48) from one another wherein each elongated filtration fiber (40) is bound to respective adjacent elongated filtration fibers (40) in a co-planar configuration, and wherein the co-planar configuration of filtration fibers (40) are rolled into a coil (34). Furthermore, a filtration membrane assembly comprising the filtration membrane bundle (30) and a housing and method of providing the filtration membrane bundle (30) are disclosed.

A method for forming a ceramic membrane module system includes disposing at least one membrane (118) within a housing (120), the membrane (118) having capillaries therein. The method includes sealing the first housing end (122) and capillaries, applying force to the removable gasket with an external frame assembly (200), and disposing potting material into the housing (120) without plugging the capillaries with the potting.

A method for forming a ceramic membrane module system includes disposing at least one membrane within a housing, disposing at least one sealing pad adjacent to the membrane, and disposing at least one drive plate assembly adjacent to the at least one sealing pad. The method further includes coupling the at least one drive plate assembly with the housing, applying force to the sealing pad with the drive plate assembly, sealing the capillaries of a membrane end with the at least one sealing pad and forming a seal between the at least one sealing pad and the membrane, and disposing potting material into the housing without plugging more than 15% of the capillaries with the potting material.

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.