An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. The junction structure can be configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. The junction structure can also include attachment structure located on the junction body and configured to attach the junction structure to the housing of the compounding device at a location downstream of a pump system.

Droplet-based methods of analysis. In an exemplary method, a device having a port connected to a chamber may be selected. A sample-containing fluid may be placed into the port. A pressure differential may be created that drives the sample-containing fluid from the port to the chamber and separates the sample-containing fluid into droplets. A two-dimensional monolayer of the droplets may be formed in the chamber. At least a portion of the monolayer may be imaged.

A microfluidic device and a system comprising such a microfluidic device or chip and a method for mixing and distributing fluids using said chip or system, wherein the microfluidic device for mixing and distributing fluids, formed by bonding of a first substrate and a second substrate, wherein open formations on bonded the first and second substrate form at least part of a microfluidic channel network comprising at least one microstructure comprising a single receiving chamber which is connected by at least one first channel extending from said single receiving chamber leading into an at least first target chamber, wherein the at least one first channel extends clockwise or counter clockwise from the single receiving chamber and is bowed in a clockwise or counter clockwise direction.

A liquid fuel injection assembly for a gas turbine engine is provided. The liquid fuel injection assembly includes at least one micromixer, at least one liquid fuel injection nozzle, and at least one post. The at least one micromixer includes at least one wall defining a conduit. The at least one liquid fuel injection nozzle extends from the at least one wall into the conduit. The at least one liquid fuel injection nozzle has a first drag coefficient. The at least one liquid fuel injection nozzle is configured to inject a flow of liquid fuel into the flow of air. The at least one post extends from the at least one wall and circumscribes the at least one liquid fuel injection nozzle. The liquid fuel injection nozzle and post have a second drag coefficient. The first drag coefficient is greater than the second drag coefficient.

A spatially selective surface functionalization device configured to generate a pattern of micro plasmas and functionalize a substrate surface may include: a pattern management system, a patterning head, and a gas delivery system, wherein the gas delivery system provides a primed gas mixture for forming a plasma between the patterning head and a target substrate below the patterning head. A patterning head may generate a distribution of micro plasmas from individual directed beams of electrons with spatial separation. A pattern management system may store and manipulate information about a pattern of surface functionalization and generate instructions for regulating a distribution of micro plasmas that functionalize a substrate surface.

The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.

An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. The junction structure can be configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. The junction structure can also include attachment structure located on the junction body and configured to attach the junction structure to the housing of the compounding device at a location downstream of a pump system.

A microfluidic printing nozzle for 3D printing may include a mixing chamber, a first inlet for connecting with a first ink source, the first inlet located at a first end of the mixing chamber, and a second inlet for connecting with a second ink source, the second inlet located at the first end of the mixing chamber. An outlet may be located at a second end of the mixing chamber, and a generally cylindrical impeller may be rotatably disposed in the mixing chamber between the first end and the second end. The cylindrical impeller may include an outer surface, and the outer surface of the impeller includes a groove, a protrusion, or both, to facilitate mixing of fluidic inks flowing from the first end to the second end of the mixing chamber.

The present invention relates to fluidic devices, especially microfluidic devices, for aliquoting and pairwise combinatorial mixing of a first set of liquids with a second set of liquids. The device architecture is designed to move liquids in two separate phases, a first phase where the liquids are exposed to a first directional force field to move the liquids in a first direction, from a reservoir to aliquot chambers, and a second phase where the liquids are exposed to a second directional force field to move the liquids in a second direction, from the aliquot chambers to the mixing chambers. The first and second directional force fields that the device is exposed to may be achieved using a single directional force field (i.e. a rotor driven centrifugal force field) and by re-orienting the position of the device with respect to the centrifugal forces between the first and second phases of operation. The device architecture comprises reservoirs for each of the first fluids and reservoirs for each of the second fluids. Each reservoir is fluidically connected to aliquoting chambers, either arranged in parallel or in series, for providing aliquots of the fluid which may be metered. The conduits providing fluid communication between the reservoirs and aliquoting chambers are arranged in a first direction. A series of mixing chambers is also provided, and each mixing chamber is fluidically connected to one aliquot chamber for a first liquid and one aliquoting chamber for a second liquid. The conduits providing fluid communication between the aliquoting chambers and mixing chambers are arranged in a second direction.

Microfluidic devices, systems, and methods for mixing a solution are disclosed, comprising a microfluidic device (100) having a first chamber (110) connected via a connection channel to a second chamber (116) that in operation is only in fluidic communication with the first chamber of the device (100). In the method, solution in the first chamber (110) is forced into the second chamber (116), compressing the air trapped within the second chamber (116), and then that solution is returned to the first chamber (110). On return to the first chamber (110), the solution exits the connecting channel (115) and causes mixing in the first chamber (110).