The present disclosure provides Molecularly Imprinted Polymer (MIP) technology for selectively sequestering one or more target molecules from chemical mixtures. Also disclosed herein are MIP beads and methods of making and using thereof.

The disclosure discloses a nicotinamide dummy template surface molecularly imprinted polymer, a preparation method and application thereof, and belongs to the technical field of chemical materials. The preparation method of the disclosure includes the steps of preparing a modified silica gel carrier, preparing a dummy template surface molecularly imprinted polymer and the like. The disclosure uses nicotinamide, a structural analogue of imidacloprid and acetamiprid, as a dummy template to prepare a silica gel surface molecularly imprinted polymer. The polymer not only can effectively avoid pollution caused by the leakage of template molecules, but also can specifically remove imidacloprid and acetamiprid from water-soluble tea extracts. The removal rate of imidacloprid and acetamiprid is greater than 96% and 93%, respectively, and the loss of tea polyphenols in the extracts is less than 10%. In addition, the molecularly imprinted adsorption column prepared by the disclosure can be eluted with ethanol solution, and the eluted adsorption column can be recycled, so the disclosure can be well applied to the preparation technology of tea extracts and has good application prospects.

A colorimetric sensor for detecting an analyte of interest that includes a metal layer disposed upon a substrate, a plurality of nanostructures, and a corresponding plurality of metal deposits spaced apart from the metal layer. The metal layer defines a plurality of holes, each nanostructure includes a first portion disposed within a respective hole, and each metal deposit is disposed upon a second portion of a respective nanostructure. The sensor also includes a molecularly imprinted polymer layer that may cover the metal layer, the nanostructures, and/or the metal deposits. The molecularly imprinted polymer layer defines a cavity shaped to receive the analyte of interest, and the sensor is configured such that, when an analyte contacts the molecularly imprinted polymer layer and becomes disposed within the cavity, an optical property of at least a portion of the sensor changes thereby to cause a detectable color change in and/or from the sensor.

Disclosed is agents and methods that target metabolism malfunctions, inborne as well as acquired, as well as methods for preparation of the agents. In particular, the invention relates to methods for preparing molecular imprinted polymers with high binding capacity for phenylalanine or tyrosine, MIPs that bind phenylalanine or tyrosine, and methods for treating phenylketonuria, alkaptonuria, and hypertyrosinemia.

The present disclosure provides Molecularly Imprinted Polymer (MIP) technology for selectively sequestering one or more target molecules from chemical mixtures. Also disclosed herein are MIP beads and methods of making and using thereof.

A separation medium for use in the separation of analytes from a feed stream containing suspended solids, processes of separation using the separation medium, and the use of the separation medium to separate analytes from a feed stream containing suspended solids. The separation medium is provided as a hydrogel having a structure whose surfaces are defined by a triply periodic minimal surface, the hydrogel comprising at least one ligand that binds at least one target analyte.

A polymer-based sensor for detecting agricultural analytes is disclosed, including stable polymer-based sensing films such as molecular imprinted polymers (MIPs) that can be incorporated in sensors for detecting herbicides and pesticides, as well as methods of making the sensing films.

A method for producing porous particles of a cross-linked polymer, and porous particles that can be produced according to the method are disclosed. The porous particles of a crosslinked hydroxy- or amino-group-containing polymer have a relatively low swelling factor. A composite material contains the porous particles dispersed in a continuous aqueous phase. The porous particles, or the composite material, are used for purifying organic molecules and for bonding metals from solutions. A filter cartridge contains the porous particles of a cross-linked polymer or the composite material.

Disclosed is agents and methods that target metabolism malfunctions, inborne as well as acquired, as well as methods for preparation of the agents. In particular, the invention relates to methods for preparing molecular imprinted polymers with high binding capacity for phenylalanine or tyrosine, MIPs that bind phenylalanine or tyrosine, and methods for treating phenylketonuria, alkaptonuria, and hypertyrosinemia.

A system and method that includes flowing brine containing a metal ion through a reactor that includes porous particles having metal ion imprinted polymer having selective binding sites. The system and method further include discharging the brine from the reactor, contacting the porous particles with water, and pressurizing the reactor with carbon dioxide. The carbon dioxide reacts with the adsorbed metal ions to form a metal carbonate solution, where the metal carbonate solution can then be continuously purified with ion exchange. The method can include recycling eluent from the ion exchange back into the system for re-use. The method further includes depressurizing the reactor to precipitate metal carbonate from the metal carbonate solution and discharging the metal carbonate solution from the reactor.