Provided is a method for measuring the concentration of aliphatic hydroxy oxime and neodecanoic acid using gas chromatography. The method includes the steps of: (a) removing, from a reference material containing an extractant and a diluent, the diluent using a silica column; (b) generating a calibration curve by calculating each peak area of aliphatic hydroxy oxime and neodecanoic acid, which are extractants, by peak integration of gas chromatograms; and (c) calculating the peak area of the organic solvent used in DSX process through the steps (a) and (b) and comparing the peak area with the calibration curve of the step (b) to measure the concentration of aliphatic hydroxy oxime and neodecanoic acid.

Provided herein are stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations.

Provided herein are stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations.

The present invention relates to a multi-column for isolating exosomes and an exosome isolation method, for isolating exosomes from a biological sample containing exosomes mixed with impurities such as lipoproteins and water-soluble proteins.

The present disclosure provides a porous silica having an average pore diameter of at least 210 and a pore volume of at least 0.80 cm.sup.3g.sup.1. The present disclosure also provides a method of producing the porous silica including gelling a liquid phase-dispersed nanoparticulate silica in the presence of either (i) a Brnsted acid and an amine group having two or more primary or secondary amine groups or (ii) an amino acid.

The present disclosure provides a porous silica having an average pore diameter of at least 210 and a pore volume of at least 0.80 cm.sup.3g.sup.1. The present disclosure also provides a method of producing the porous silica including gelling a liquid phase-dispersed nanoparticulate silica in the presence of either (i) a Brnsted acid and an amine group having two or more primary or secondary amine groups or (ii) an amino acid.

The present disclosure provides a porous silica having an average pore diameter of from 20 to 450 , a median (D50) pore diameter of from 20 to 450 , a pore volume of from 0.15 to 1.2 cm.sup.3 g.sup.1, a surface area of from 100 to 600 m.sup.2 g.sup.1, and a span of 0.80 or less. The present disclosure also provides a method of producing the porous silica. The method includes the step of mixing together an aqueous phase comprising nanoparticulate silica and an organic phase to form a water-in-oil dispersion or emulsion. The organic phase includes an organic solvent that is insoluble or partially soluble in water and optionally also includes a non-polar organic compound that is insoluble in water and at least partially soluble in the organic solvent. A gelling agent is present in the aqueous phase such that the nanoparticulate silica gels form the porous silica.

The present disclosure provides a porous silica having an average pore diameter of from 20 to 450 , a median (D50) pore diameter of from 20 to 450 , a pore volume of from 0.15 to 1.2 cm.sup.3 g.sup.1, a surface area of from 100 to 600 m.sup.2 g.sup.1, and a span of 0.80 or less. The present disclosure also provides a method of producing the porous silica. The method includes the step of mixing together an aqueous phase comprising nanoparticulate silica and an organic phase to form a water-in-oil dispersion or emulsion. The organic phase includes an organic solvent that is insoluble or partially soluble in water and optionally also includes a non-polar organic compound that is insoluble in water and at least partially soluble in the organic solvent. A gelling agent is present in the aqueous phase such that the nanoparticulate silica gels form the porous silica.

Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.

Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.