The present invention relates to a flow-through device comprising at least one separation column wherein a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts are provided. The two packing components may be blended or layered in the device, which may comprise a single tube or a plurality of tubes arranged in a plate format, such as the wells of a multiwall plate or tubes in a rack. In addition, the invention relates to a method for removing one or more matrix components, such as pigments, from a biological sample, by passing said sample across a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts.

The invention relates to a method for manufacturing a multicapillary packing for an exchange of material including the formation, by a 3D printing method, of a monolith having a porous mass through which a plurality of parallel channels passes, opening on an inlet face and an outlet face of the packing, the 3D printing method being chosen among: selective laser sintering, molten wire deposition, stereolithography, binder spraying and spraying of material, the porous mass being suitable for allowing the diffusion of material to be exchanged between the channels.

The invention relates to a method for manufacturing a multicapillary packing for an exchange of material including the formation, by a 3D printing method, of a monolith having a porous mass through which a plurality of parallel channels passes, opening on an inlet face and an outlet face of the packing, the 3D printing method being chosen among: selective laser sintering, molten wire deposition, stereolithography, binder spraying and spraying of material, the porous mass being suitable for allowing the diffusion of material to be exchanged between the channels.

A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.

A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.

Chromatography method in which a gaseous, liquid or supercritical mobile phase containing species to be separated is circulated through a packing, said packing being characterized in that: it comprises a plurality of capillary ducts extending in the packing between an upstream face through which the mobile phase enters the packing and a downstream face through which the mobile phase leaves the packing—the material of the walls comprises a first population of connected pores, providing passages from one duct to the next enabling molecular diffusion to take place between adjacent ducts, pores having a mean diameter (d.sub.pore) of greater than 2 times the molecular diameter of at least one species to be separated—the diameter of the ducts is less than 50 μm.

Described is a filter-drier core for removing acids and halides that are generated by decomposition of a refrigerant that contains a fluoroiodocarbon, the filter drier core comprising a molded core that includes gamma phase activated alumina and a molecular sieve. The molecular sieve has a pore size between 3-4 angstroms and between 300-00 m.sup.2/g surface area, and/or the alumina is provided in a beaded form with average bead diameter between 0.1-10 mm. An alumina surface area may be between 140-250 m.sup.2/g, and an average pore size may be 6 nm to 16 nm. A percent molecular sieve in the core may be between 0-40%, with the rest of the core being alumina. To increase surface area of the core, the filter-drier core may define a plurality of suitably shaped channels that extend longitudinally through the core, may have fins that extend from a central body, or may be configured as a plurality of rods. A refrigerant system includes a refrigerant circuit through which a refrigerant flows, and a filter-drier unit including the filter-drier core configured for contact with the refrigerant for removing contaminants from the refrigeration system.

Described is a filter-drier core for removing acids and halides that are generated by decomposition of a refrigerant that contains a fluoroiodocarbon, the filter drier core comprising a molded core that includes gamma phase activated alumina and a molecular sieve. The molecular sieve has a pore size between 3-4 angstroms and between 300-00 m.sup.2/g surface area, and/or the alumina is provided in a beaded form with average bead diameter between 0.1-10 mm. An alumina surface area may be between 140-250 m.sup.2/g, and an average pore size may be 6 nm to 16 nm. A percent molecular sieve in the core may be between 0-40%, with the rest of the core being alumina. To increase surface area of the core, the filter-drier core may define a plurality of suitably shaped channels that extend longitudinally through the core, may have fins that extend from a central body, or may be configured as a plurality of rods. A refrigerant system includes a refrigerant circuit through which a refrigerant flows, and a filter-drier unit including the filter-drier core configured for contact with the refrigerant for removing contaminants from the refrigeration system.

A mobile phase including a lithium salt flows through a stationary phase including an oxygenated metal compound with affinity to the lithium salt through a Lewis acid-Lewis base interaction so that the oxygenated metal compound captures the lithium salt through the Lewis acid-Lewis base interaction. An eluent flows through the stationary phase to release the lithium salt captured by the oxygenated metal compound into the eluent. The eluent includes a Lewis base or a Lewis acid that disrupts the Lewis acid-Lewis base interaction between the lithium salt and the oxygenated metal compound. The eluent including the released lithium salt is collected after the eluent flows through the stationary phase.

A mobile phase including a lithium salt flows through a stationary phase including an oxygenated metal compound with affinity to the lithium salt through a Lewis acid-Lewis base interaction so that the oxygenated metal compound captures the lithium salt through the Lewis acid-Lewis base interaction. An eluent flows through the stationary phase to release the lithium salt captured by the oxygenated metal compound into the eluent. The eluent includes a Lewis base or a Lewis acid that disrupts the Lewis acid-Lewis base interaction between the lithium salt and the oxygenated metal compound. The eluent including the released lithium salt is collected after the eluent flows through the stationary phase.