A subject of the invention is a fluidized-bed reactor for producing granular polycrystalline silicon. The fluidized-bed reactor comprises a segmented reactor tube, which is disposed between a reactor top and a reactor bottom, a heating facility, at least one nozzle for supplying fluidizing gas, at least one nozzle for supplying reaction gas, a facility for supplying silicon seed particles, a product removal line, and an offgas removal line. The segmented reactor tube comprises a base segment and at least one spacer segment, there being disposed, between base segment and spacer segment, a flat seal made from a carbon-containing material, the spacer segment consisting of a material which, within a temperature range from 100 to 950° C., has a thermal conductivity of <2 W/mK.

The present invention provides an improved process for removing heat from an exothermic reaction. In particular, the present invention provides a process wherein heat can be removed from multiple reaction trains using a common coolant system.

Plant for the synthesis of melamine starting from urea, wherein the stream of offgas containing NH.sub.3 and CO2 produced by the synthesis of melamine is converted into urea in a dedicated urea plant.

Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

A reactor for conducting exothermic equilibrium reactions, especially for the performance of methanol synthesis by heterogeneously catalysed conversion of synthesis gas, is proposed, which enables readjustment and hence optimization of the reaction conditions along the longitudinal coordinate of the reactor. For this purpose, in accordance with the invention, the reactor is divided into a multitude of series-connected reaction cells, each of which comprises a preheating zone, a cooled reaction zone, one or more cooling zones and a deposition zone for condensable reaction products. In this way, the reaction conditions are adjustable to the respective, local composition of the reaction mixture and variable over the reactor length.

The present disclosure relates to a volume tailorable manufacturing system for quality assured manufacturing of biosafety level classified biopharmaceutical products and a method for tailoring a production volume capability of a manufacturing system. The volume tailorable manufacturing system comprises one or more multi-product suites and a control facility configured to control a unidirectional flow in a circulation system of the one or more multi-product suites. The circulation system is configured to interconnect the one or more multi-product suites and comprises separated supply and return systems. The supply system comprising at least one inlet, the return system comprising at least one outlet that is paired with the inlet and provided at a spatially predetermined position from the inlet, and each inlet/outlet pair comprises a seal when not connected to an adjacent multi-product suite.

The present invention provides an improved process for removing heat from an exothermic reaction. In particular, the present invention provides a process wherein heat can be removed from multiple reaction trains using a common coolant system.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

A method for producing a cyanide including the steps of supplying a hydrocarbon and nitrogen source to an onsite plasma reactor and removing cyanide synthesised inside the onsite plasma reactor to thereby produce the cyanide is disclosed. Also disclosed is a method which includes a monitor for monitoring the cyanide requirement of an onsite cyanide utilising system and supplying the hydrocarbon and nitrogen source in accordance with the cyanide requirement. Additionally, a method for recovering, refining, purifying or treating a metal including the steps of monitoring a cyanide requirement of the method and supplying to the method in a just in time sequence a cyanide synthesised onsite to thereby recover, refine, purify or treat the metal is disclosed.