The present disclosure relates to a continuous production method of a diester-based material in a continuous production process comprising a reaction part in which a total of N reaction units from a first reaction unit to an N-th reaction unit are connected in series. The method comprising the step of feeding dicarboxylic acid and a primary alcohol, wherein the feed of the primary alcohol is divided into front-end feed of being fed into a first reaction unit and rear-end feed of being fed into one or more reaction units selected among from a second reaction unit to an N-th reaction unit, wherein the amount of the rear-end feed is 5 to 80 wt % based on the total feed amount of the primary alcohol into a reaction part, and the N is an integer of 3 to 6. According to the present invention, it is possible to ensure the ease of process operation through reducing the amount of reflux compared to a typical batch process and reducing the volume of steam for heating a reactor, and to ensure the economic feasibility of a product through saving energy.

A continuous tubular reactor includes a rotary reaction tube having a reactant inlet and a product outlet, and including a ceramic; a heating device disposed outside the rotary reaction tube; and an angle adjuster adjusting an angle of a rotation axis of the rotary reaction tube. The angle of the rotation axis is 75° or less with respect to a horizontal surface.

The present disclosure relates to a method for producing trifluoroiodomethane (CF.sub.3I) from iodine (I.sub.2) and trifluoroacetic anhydride (TFAA) under photochemical conditions using ultraviolet (UV) light.

A process for a continuous production of a boronic acid derivative and an apparatus of performing the process are disclosed.

The invention relates to a continuously operating process for producing nitrobenzene, comprising the following steps: a) nitriding benzene in adiabatic conditions with sulfuric acid and nitric acid, using a stoichiometric excess of benzene in relation to the nitric acid; b) first separating a gaseous phase containing benzene and gaseous secondary components from the raw process product of the nitridation in a gas separator provided specifically for this purpose, then separating, in a downstream phase-separating apparatus, the resulting liquid phase, which is depleted in gaseous components and contains nitrobenzene and sulfuric acid, into a sulfuric acid phase and a nitrobenzene phase; and c) processing the nitrobenzene phase, obtaining nitrobenzene. The invention also relates to a production plant suitable for carrying out the claimed process.

The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, C—C coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.

Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.

The present disclosure relates to a continuous flow process for preparing conducting polymers, for example polyaniline. The continuous flow process can provide a controlled synthesis of a conducting polymer from an emulsion comprising a polymerizable organic monomer and a free radical initiator in flow within a temperature controlled continuous flow reactor comprising at least one mixing element. The present disclosure also relates to the conducting polymers prepared by the continuous flow process.

A process for the oxidation of powder materials containing starch, which comprises the steps of mixing a powder material comprising starch with an aqueous solution of hydrogen peroxide (H.sub.2O.sub.2), adding to the mixture thus obtained an aqueous solution of ammonia which reacts with said mixture and drying the mixture to obtain a powder material containing oxidized starch.

The invention refers to a modular continuous flow device for automated chemical multistep synthesis under continuous flow conditions. The device comprises a plurality of different types of continuous flow modules and a valve assembly for connecting the continuous flow modules to each other in a parallel or radial manner. This arrangement allows conducting chemical reaction sequences by pre-synthesizing and intermediately storing or simultaneously synthesizing at least one intermediate product which is needed in the main synthetic reaction sequence in order to obtain the final product.