A flow reactor fluidic module (12) includes a reactant fluid module (20) having an internal process fluid passage (22) and a first major planar outer surface (24a) and a thermal resistance R between the internal process fluid passage (22) and the first major planar surface (24); a thermal control fluid module (30) having an internal thermal control fluid passage (32) and a second major planar outer surface (34a); a holding structure (50) holding the reactant fluid module (20) and the thermal control fluid module (30); and a gap (25) separating the first major planar surface (24a) from the second major planar surface (34a). The gap (25) comprises an interchangeable or replaceable substance or sheet (26) having a thermal resistance G across the gap (25), wherein G is not equal to R.

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Radiation-sensitive material embedded in a disposable radiochemistry device gives the device the additional capability of recording radiation dose, for readout at a later time. There is provided a device comprising means for the introduction of a precursor compound, means for the introduction of a radionuclide, a reaction vessel for reacting said precursor compound and said suitable source of a radionuclide to obtain a radiolabelled compound, and one or more pieces of radiation-sensitive material embedded into said device wherein at least one of said pieces is positioned to be exposed to radioactivity associated with said radiolabelled compound.

A chemical reactor and method for operation. The reactor enables N pairwise fluid contacts among k chemical fluids, with k2 and N4 and comprises: a reaction layer extending in a plane subtended by two directions; N chemical cells, each including two circuit portions, designed for enabling circulation of two of the k chemical fluids, respectively, the two circuit portions intersecting each other, thereby enabling one pairwise fluid contact for the two of the k chemical fluids; and a fluid distribution circuit comprising: k sets of inlet orifices sequentially alternating along lines parallel to one of the two directions, for respectively dispensing k chemical fluids to the reaction layer; and k sets of outlet orifices sequentially alternating along lines parallel to the inlet orifices, for respectively collecting k chemical fluids from the reaction layer, and wherein, each circuit portion connects an inlet orifice to an outlet orifice.

A plate-type flow reactor device with a first plate (20) having first and second opposing surfaces (22, 24) and one or more through-holes (26); a second plate sealed against the first surface (22) by at least two first O-rings (50); a third plate (40) sealed against the second surface (24) by at least one second O-ring (60); two or more first elongated channels (70) defined between the first surface (22) and the second plate and one or more second elongated channels (80) defined between the second surface (24) and the third plate, wherein each first channel communicates with the at least one second channel (80) via one or more of the through-holes (26) through the first plate (20), and said one first channel (70a) communicates with another first channel (70b) of the two or more first channels (70) only via said at least one second channel (80), and each first channel (70) is individually surrounded by at least one of the first O-rings (50) and the at least one second is individually surrounded by the at least one second O-ring (60).

A flow reactor has a module (12) that comprises at least first (20), second (30), and third (40) parallel plates stacked temporarily or permanently together and defining a first thermal fluid layer (25) between the first (20) and second plates (30) and a process fluid layer (35) between the second (30) and third plates (40), the process fluid layer (35) comprising a process fluid passage (32) having two or more U-bends and three or more successive process fluid passage segments joined by respective U-bends, the first thermal fluid layer (25) comprising at least two open thermal fluid channels (26) in the second plate (30), the at least two open channels (26) positioned, when viewed in a plan view of the module (12), between respective adjacent process fluid passage segments.

A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).

The present invention provides methods, systems and apparatus in which one fluid passes through an orifice or orifices and mixes with another fluid as it flows through a microchannel.

A method of performing a reaction is disclosed comprising flowing a reaction mixture (50) comprising HF past a compression seal (40) within a flow reactor (20), wherein the compression seal (40) includes an O-ring or gasket (30, 32) and where the O-ring or gasket (30, 32) comprises fluoroelastomer (to include fluoroelastomers and perfluoroelastomers), while maintaining the reaction mixture comprising HF at a temperature of 50 C. or greater [generally at a temperature in the range of from 50 C. and greater (60, 70, 80, 90, 100, 120, 150, and 180 C.) up to 220 C.], using O-rings or gaskets (30, 32) that comprise a fluoroelastomer having a pre-use tensile strength in the range of from 0.1 to 14 MPa measured according to IS037, and desirably further having a compressive set in the range of from 0 to 12% measured according to IS0815.

The present invention relates to a nanoporous thin film and a method for fabricating the same. The nanoporous thin film fabricating method for fabricating a nanoporous thin film with a composite photocatalyst structure for a photodegradation and a water purification includes providing a porous substrate with a plurality of through-nanopores therein, each of which through-nanopores have an inner tube wall; forming an oxide-based photocatalyst layer over the porous substrate and the inner tube wall by using a first chemical-based deposition process; and forming a metal-based photocatalyst layer on a part of the oxide-based photocatalyst layer by using a second chemical-based deposition process.