The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

A plate-type flow reactor device with a first plate (20) having first and second opposing surfaces (22, 24) and one or more through-holes (26); a second plate sealed against the first surface (22) by at least two first O-rings (50); a third plate (40) sealed against the second surface (24) by at least one second O-ring (60); two or more first elongated channels (70) defined between the first surface (22) and the second plate and one or more second elongated channels (80) defined between the second surface (24) and the third plate, wherein each first channel communicates with the at least one second channel (80) via one or more of the through-holes (26) through the first plate (20), and said one first channel (70a) communicates with another first channel (70b) of the two or more first channels (70) only via said at least one second channel (80), and each first channel (70) is individually surrounded by at least one of the first O-rings (50) and the at least one second is individually surrounded by the at least one second O-ring (60).

The invention relates to a heat exchanger-reactor or heat exchanger including at least three stages with on each stage at least one area of millimetric channels that promote the exchange of heat and at least one distribution area upstream and/or downstream of the area of millimetric channels. The invention is characterized in that: said heat exchanger-reactor or heat exchanger is a component devoid of assembly interfaces between the various stages; and the channels in the area of millimetric channels are separated by walls less than 3 mm thick.

The present invention provides a micro-reactor (1) adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor (1) comprising a fluid inlet (2) and a fluid outlet (3); a plurality of micro-reaction chambers (10) arranged in rows (7) and columns (6), each micro-reaction chamber comprising a chamber inlet (10a) and a chamber outlet (10b); a plurality of supply channels (4) for supplying fluid to from said fluid inlet (2) to said micro-reaction chambers (10) and further arranged for draining said micro-reaction chambers (10) to said fluid outlet (3), said supply channels (10) extending in a first direction (D1) along the columns (6) of micro-reaction chambers (10) and arranged such that there is one supply channel (4) between adjacent columns (6). The micro-reaction chambers (10) in the columns (6) are arranged such that the chamber inlets (10a) of a column are in fluid contact with the same supply channel (4) and the chamber outlets (10b) are in fluid contact with the supply channel (4) adjacent to the supply channel (4) arranged in fluidic contact with the chamber inlets (10a). Further, the plurality of supply channels (4) comprises a first end supply channel (4a) arranged for supplying fluid to a first end column (6a) of the micro-reaction chambers (10) and a second end supply channel (4b) arranged for draining fluid from the second, opposite, end column (6b) of said micro-reaction chambers (10); and wherein the micro-reactor (1) further comprises at least one reagent inlet (8) in fluid contact with the first end supply channel 4a and a reagent outlet (9) in fluid contact with the second end supply channel such that reagents introduced to the at least one reagent inlet (8) fill the plurality of micro-reaction chambers (10) in a second direction (D2) along the rows (7) of micro-reaction chambers (10) to the reagent outlet (9).

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Various implementations provide an inherently safer design feature for microchannel reactors that provides temperature control at the individual channel level. This approach relies on bimetallic strips embedded within the combustion channel, forming a thermally-actuated valve. Bimetallic strips convert a temperature change into a mechanical displacement. Heating the strip increases its deflection and thereby restricts flow in the combustion channels, which consequently reduces the rate of heat generation. The thermally-actuated valve is not limited to use in microchannel reactors and may be used in other structures for which thermally actuated flow control is desired, according to some implementations.

The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer.

There is provided a master for micro flow path creation, a transfer copy, and a method for producing a master for micro flow path creation by which transfer copies having an area with high hydrophilicity can be easily mass-produced, the master for micro flow path creation including: a base material; a main concave-convex portion provided on a surface of the base material and extending in a planar direction of the base material; and a fine concave-convex portion provided on a surface of the main concave-convex portion and having a narrower pitch than the main concave-convex portion. The fine concave-convex portion has an arithmetic average roughness of 10 nm to 150 nm and has a specific surface area ratio of 1.1 to 3.0.

Disclosed is a reactor-exchanger or an exchanger comprising at least 3 levels, each of which includes at least one region with millimeter channels promoting heat exchange and at least one distribution region upstream and/or downstream of the region with millimeter channels, characterized in that the reactor-exchanger or exchanger is a unit that has no mounting interfaces between the various levels.

Systems and methods for confining droplets within a microfluidic channel as well as systems and methods for packing droplets are provided. More specifically, a system and method are provided for controlling the introduction and removal of oil into a microfluidic channel in order to control where drops are allowed to flow within that channel.