A cassette assembly (1) comprises a cover (100), two cassette halves (200A, 200B) and a slider (300) comprising multiple test chambers (302). The cassette halves (200A, 200B) comprise waste tanks (230) in fluid connection with reservoirs (240), prefilled in one of the cassette halves (200A, 200B) with test agents. The particular design of the cassette halves (200A, 200B) enable forming predefined 5 volumes of liquid to achieve predefined concentrations of the test agents in the reservoirs (240) in one of the cassette halves (200A, 200B) and liquid in the reservoirs (240) in the other of the cassette halves (200A, 200B). Gradients of the test agents can then be established over the multiple test chambers (302).

An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. Each sample containers holds a distinct microorganism-attracting substance and a portion of a fluid sample containing an unknown microorganism. Each distinct microorganism-attracting substance is configured to bind with a single type of microorganism. The unknown microorganism in the fluid sample binds with the distinct microorganism-attracting substance in a single sample container. The instrument incubates the microorganism in the single sample container and detects the presence of the microorganism in the single sample container to thereby simultaneously identify the unknown microorganism.

A method of detecting SARS-CoV-2 virus antigen present in oropharyngeal lavage comprises: abstaining from food and drink for a first period of time before collecting the oropharyngeal lavage; pouring a non-alcoholic mouth rinse into the oral cavity, and swishing and gargling the non-alcoholic mouth rinse for a second period of time; inserting an absorbent end of a fluid collector comprising an absorbent material into the oral cavity to collect the oropharyngeal lavage from the oral cavity; removing the absorbent end of the fluid collector from the oral cavity; inserting the fluid collector into the sample receiving member of an analyte testing device for testing a fluid sample, with the absorbent end facing downward; and after a third period of time, reading a first indicator on a first test strip in the device to determine whether SARS-CoV-2 virus antigen is detected in the oropharyngeal lavage.

The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprise one or more fluid over-flow reservoirs, wherein the over-flow reservoirs are operatively connected to a distribution channel by a fluid over-flow channel. In another embodiment, the sample test cards may comprise a plurality of flow reservoirs operable to trap air thereby reducing and/or preventing well-to-well contamination. The test card of this invention may comprise from 80 to 140 individual sample wells, for example, in a test card sample test cards of the present invention have a generally rectangular shape sample test card having dimensions of from about 90 to about 95 mm in width, from about 55 to about 60 mm in height and from about 4 to about 5 mm in thickness.

The microfluidic board comprises a plurality of matrix units, wherein each matrix unit is a stacked arrangement comprising a driving portion comprising an actuator, a pump portion in contact with the driving portion and comprising a pump, a channel portion in contact with the pump portion and comprising one or more channels, and a chamber portion in contact with the channel portion and comprising a chamber, wherein the one or more channels are configured to direct fluid between the pump and the chamber, and wherein the actuator is configured to generate a force to drive the pump upon receiving of an input energy.

A fluid sample testing apparatus has a housing with a test chamber and first and second fluid collector tubes and first and second fluid collectors in fluid communication with the test chamber. A sample holding container is in fluid communication with the second fluid collector tube. The first fluid collector is inserted into the first fluid collector tube and pressure is generated to release fluid from the first fluid collector into the test chamber, and air passes outside of the apparatus from the test chamber via an opening from the test chamber into the first fluid collector tube. The second fluid collector is inserted into the second fluid collector tube concurrently and pressure is generated to release fluid from the second fluid collector into the sample holding container, and air passes outside of the apparatus from the second fluid collector tube.

Described herein are systems and methods for dividing a population of particles into two or more subpopulations, reacting each formed subpopulation of particles with a different reagent, pooling the reacted subpopulations of particles back together.

A fluid delivery device includes at least one area onto which at least one support element having at least one well may be placed in a defined position. The fluid delivery device further includes at least one pipetting device having a connector configured to releasably connect the at least one pipetting device with a disposable tip and with a fluid displacement element which enables aspiration and ejection of a defined volume of liquid to or from the disposable tip. The at least one pipetting element is movable in a vertical and preferably in at least one horizontal direction. The fluid delivery device also includes a blowing element that has at least one aperture coupled to a source of pressurized gas and is movable in a vertical and preferably at least one horizontal direction. A system includes such a fluid delivery device and the at least one support element.

A fluidic storage device capable of long-term storage of biological, chemical, and biochemical substances, including fluids and solids of a corrosive nature or generally incompatible with traditional reagent storage methods like blister packs. The fluidic device employs a fiber-based substrate which allows the substance to be stored long-term within the structure of the fiber-based substrate through capillary action. The stored substance can be released from the fiber-based substrate and used as needed as a result of active or passive forces incurred on the fluidic device. The storage as described herein will assist in minimizing the hazards associated with performing POI and POC testing by scaling down the required reagent volumes as well as facilitating long-term reagent storage and analysis on a single integrated, portable fluidic device.

Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. The sample may also be mixed with other material(s) in the collection device.