The present invention relates to a biological sample collection kit, which uses a unique dry preservative for the preservation of nucleic acids, DNA and RNA, for collection, stabilization, transportation and long-term room temperature storage of biological samples that can be from sources such as saliva for molecular diagnostic applications. The invention features a collection device for biological samples such as saliva containing nucleic acids, and dry preservatives that are affixed directly or to a carrier substrate and placed within the collection device such that the samples come into contact with the dry preservatives resulting in the preservation and stabilization of the nucleic acids.

A biological false bottom transport tube system includes a top section of a specimen tube body, the top section comprising a top, a semi-spherical interior floor, and a bottom below the interior floor, the top section manufactured from a material transparent to both visible and infrared light, wherein the top section may hold a sample on the interior floor; and a bottom section of the specimen tube body, the bottom section comprises a top of a diameter less than a dimeter defined by a remainder of the bottom section, the top of the bottom section fits into the bottom of the top section below the interior floor such that the top of the bottom section is secured within the bottom of the top section, the bottom section manufactured from a material that is not transparent to either visible or infrared light.

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

Fluidic systems and reagent carriers suitable for storing reagents in a desirable manner are generally provided. In some embodiments, a reagent carrier stores a liquid film comprising a solid reagent and/or stores different reagents in different locations. In some embodiments, a fluidic system comprises a reagent carrier constrained such that it comprises an elongated axis positioned within 30° of a vertical axis of the fluidic reservoir.

A collection container for biological samples is described. In one embodiment, the collection container includes a receptacle and a lid with a sampling port. The sampling port is coupled to an aspiration tube and allows access to the contents of the receptacle. A needle-free fitting allows a mating device to be coupled to the sampling port. A valve automatically closes to prevent the sample from escaping through the sampling port when a mating device is not coupled.

The present invention relates to a cell cryopreservation device, and can comprise: a first housing for accommodating a plurality of test tubes; a second housing for covering the first housing; center support ribs extended upward from the inner bottom surface of the first housing to come in contact with and support the side surfaces of the surrounding test tubes; and side support ribs extended from the inner wall surface of the first housing toward the inner side of the first housing to come in contact with and support the side surfaces of the test tubes.

A system for collecting biomolecules comprising an extractor assembly comprising a top cap, an extractor core, an extractor core adaptor, an extractor body having an internal volume, and a bottom cap ring. The top cap comprises a sample connection port and is configured to be secured to the extractor body by the bottom cap ring. The extractor core is adapted to be removably attached to a connection interface of the top cap and contains a substrate for collecting the biomolecules. The extractor core adaptor has an upstream open end for mating with the downstream end of the extractor core and a downstream protrusion configured to project through an opening in the extractor body. Methods for using the system to collect samples for transport and further processing to detect disease are also disclosed.

A method and apparatus for opening a reaction vessel having a body forming a volume for liquid, and a lid. In the method at least one reaction vessel is placed on a transport vehicle and the reaction vessel is positioned on the vehicle so that the vessel's rotation about its own axis is prevented. Then, the at least one reaction vessel is transferred on the vehicle and a guide rod, attached to the lid that is attached by a hinge to the reaction vessel, is pushed by the movement of the vehicle against a guide surface that forces the lid to turn on the hinge so that the lid is at least partially opened.

The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The present disclosure further provides methods of using the bead beating system to extract nucleic acids from cells containing the nucleic acids.

A container includes a vial, cap, and one or more wireless transponders secured to the cap, the vial or a jacket to store and identify samples of biological material at cryogenic temperatures (e.g., vitrified biological samples), for instance held by cryopreservation storage devices. A specimen holder may be extend from the cap. The vial and/or cap includes ports or vents. A carrier includes a box, thermal shunt, thermal insulation to store and identify arrays of containers that hold cryopreservation storage devices with samples of biological material at cryogenic temperatures. Various apparatus include wireless transponders positioned and oriented to enhance range, and allow interrogation while retained in a carrier. Various apparatus can maintain the biological material at or close to cryogenic temperatures for prolonged period of times after being removed from a cryogenic cooler, and can allow wireless inventorying while maintaining the biological samples at suitably cold temperatures.