The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (NGS). The microfluidic devices include a plurality of reaction modules. Each reaction module may comprise one or more reaction circuits. Each reaction circuit may comprise a single reaction flow channel with each reaction circuit connected by a bridge flow channel. Alternatively, each reaction circuit may comprise two or more reaction flow channels connected by two or more bridge flow channels. The combination of any two bridge flow channels and a portion of the two or more reaction flow channels between the any two bridge flow channels defining may define the reaction circuit. The reaction module may be arranged as nodes connected by bridge flow channels or each reaction module may be arranged in a parallel fashion on the microfluidic device.

The shock tube comprises a tube, a first electrode, a second electrode and a stopple, wherein the tube is internally provided with a cavity for accommodating a target liquid sample. The first electrode is arranged at one end of the tube. The second electrode is arranged in the stopple, and the outer end of the second electrode can be electrically connected with the exterior via an opening of the stopple. The stopple is internally provided with an elastic piece connected with the second electrode. The outer side of the elastic piece is connected with the stopple, and the inner side of the elastic piece is connected with the second electrode. The invention further provides a cell electroporation device where the shock tube can be placed.

The present invention generally includes methods, devices and/or kits for the detection of a COVID-19 infection in an individual by measuring the level or concentration or one or more ions present in a urine sample that is substantially free of COVID-19 RNA, antibodies, or antigen material.

Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.

Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.

A portable kit for generating a digital image of a faecal sample suitable for microscopic analysis, comprises a faecal sample preparation device configured to receive a faecal sample and a faecal flotation fluid, filter a suspension comprising the faecal sample and the faecal flotation fluid to provide a filtrate, a translucent faecal sample support, and a portable digital imaging module. The portable digital imaging module comprises a housing, a camera/microscopic lens assembly configured to generate a digital image of the faecal sample on the sample support, an illumination system, a seat for receiving the faecal sample support disposed between the camera/microscopic lens assembly and illumination system, a memory for storing the digital image, a communication system for communicating the digital image to an off-site image processing module via a communications network, and a battery operatively connected to the camera and microscopic lens assembly, memory and communication system.

A cartridge pre-processing device system and method receives immunoassay lateral flow assay test cartridges for development prior to submitting the cartridge for assay/analysis. The cartridge pre-processing device supports high assay throughput with reduced operator burden by automating device pre-processing timing steps without locking-down the reader that is used to perform the assay/analysis. The pre-processing device is operated in a walk-a-way mode. The pre-processing device is separate from the assay cartridge reader and is capable of automatically timing the development of an assay cartridge with minimal to no operator oversight. Additionally, the device disclosed herein is able to alert the operator when assay development is complete and when the assay has developed in excess of a predetermined flex-time associated with an individual cartridge.

An apparatus includes a pipette dispenser to control dispensing of a volume to a dispensing location. A tip is operatively coupled to the pipette dispenser. The tip includes an electromechanical print head to dispense the volume from the pipette dispenser to the dispensing location based on a command from the pipette dispenser that indicates an amount of the volume to be dispensed from the print head.

A safety cabinet includes an operation stage on which an operation is performed, an operation space in which an operator performs the operation, a front panel disposed in front of the operation space, an operation opening connected to the operation space, exhausting means that suctions air from the operation opening and exhausts air in the operation space outside the safety cabinet through air purifying means, and visualizing means that visualizes an air flow in the operation space.

The disclosure describes apparatus and methods for multiplexed amplification and detection of nucleic acid targets in a sample. Embodiments of the present disclosure include a mechanical system configured to provide loading, vertical positioning and clamping of a chip; a thermal control system configured to maintain distinct temperatures of the chip, and an optical fluorescence imaging system.