Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. An apparatus may include a first layer being substantially transparent. A second layer may be coupled to the first layer. The second layer may be substantially absorbent to infrared radiation. The second layer and the first layer may collectively define a set of wells. The first layer may define a base for each well of the set of wells. The second layer may define an opening for each well of the set of wells. At least one of the first layer and the second layer may define a sidewall for each well of the set of wells.

The present invention relates to a whole blood and fingertip blood testing device, including a blood collection structure and a testing chamber connected to and in fluid communication with the blood collection structure. The blood collection structure includes a collection rod, a capillary channel is arranged inside the collection rod, the bottom end of the capillary channel is located at the tail end of the collection rod, and the top end of the capillary channel is located in the middle of the capillary channel; and the collection rod is provided with a communicating hole connected to and communicated with the top end of the capillary channel. Moreover, the present invention also provides a method for collecting and testing a blood sample by using the testing device. Through the integrated structure of the blood collection structure, the testing chamber and the buffer chamber, the whole blood and fingertip blood testing device and method achieve functions of collecting, slowly releasing and testing the blood sample. The operation is easy, which reduces the difficulty of use by the operator. The number of times and time that the operator contacts the sample are effectively reduced, and the infectious possibility of the operator is reduced, so that the testing device is suitable for HIV testing, novel coronavirus testing, etc. The testing device and method have low requirements on the collected amount of the sample, and the collected amount is optimized from the milliliter level to the microliter level.

A device to detect pathogens and/or analytes in a test sample is designed to include a core, which may have first and second chambers. The first chamber is designed to accept a combination of a test specimen and a buffer liquid. A piston is designed to slideably engage into the first chamber of the core, wherein the end of the piston may engage with the bottom of the first chamber and be capable of grinding the test specimen. A plunger is designed to slideably engage with the second chamber of the core, and is in fluid communication with the first chamber. An assay section is attached to the core, and is in fluid communication with the second chamber. The assay device is designed to include a test strip that is capable of detecting and indicating the presence of pathogens and/or analytes in the combination of the test sample and buffer liquid.

Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.

A system and method for automated single cell capture and processing is described, where the system includes a deck supporting and positioning a set of sample processing elements; a gantry for actuating tools for interactions with the set of sample processing elements supported by the deck; and a base supporting various processing subsystems and a control subsystems in communication with the processing subsystems. The system can automatically execute workflows associated with single cell processing, including mRNA capture, cDNA synthesis, protein-associated assays, and library preparation, for next generation sequencing.

The invention relates to a system is provided that comprises a first container, a second container and a fluorescence detection device. The first container comprises a first set of chemicals and/or agents and is closed prior to use. The second container comprises a second set of chemicals and/or agents that are at least in part distinct from the chemicals and/or agents of the first set. The first container comprises a lid, that can be opened when the first container and the second container are combined to form a single, fluid tight assembly, in order to allow the contents of the first container to enter the second container.

An automatic chemical solution formulating device combines and mixes stored solids and liquids into user specified formulations and dispenses those formulations into containers. Chemical solids are stored in cartridges of material separated into predetermined dosages (for example in reeled blister packs), avoiding the need for weighing during formulation. Elements include user interface, computer-controlled automated loading and unloading port for reagent-containing cartridges, cartridge conveyor system, reader for identifying cartridges, blister-pack strip drive system, punching mechanism to release reagents, portioning chamber to mix solvent with solids or liquids with optional portioning, accommodating formulation delivery port, position sensors, liquid flow measuring devices, liquid and gas pumps and valves, and label printer. The combination of these elements allows high-speed formulation and dispensing of user-specified formulations.

A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

Apparatus is provided including a tube and a plunger sized and shaped to be inserted into the tube. A distal end of the plunger is shaped to define one or more first passageways therethrough, and the plunger is shaped to define one or more compartments in fluid communication with the first passageways. A filter is coupled to the distal end of the plunger. The plunger is shaped to define a second passageway that passes through the plunger from a proximal end of the plunger to the distal end of the plunger, and is positioned to facilitate testing of the filter. The apparatus is configured such that while the plunger is advanced within the tube while fluid is within the tube, the fluid in the tube is pushed through the filter, through the first passageways, and into the one or more compartments. Other embodiments are also described.

A sample pretreatment tube includes a first tube receiving a primary reagent and a second tube receiving a secondary reagent, wherein the sample pretreatment tube can easily perform sequential reactions by allowing a primary reaction solution to be immediately discharged from the first tube to the second tube by breaking a separation membrane formed at a lower end of the first tube using a pipette, and can limit an insertion depth of the pipette using a stopper formed inside the first tube, thereby preventing damage to the second tube due to the pipette while allowing a space to be formed inside the first tube to facilitate discharge of a primary reaction solution, thus making it possible to immediately perform secondary reaction.