Systems, methods, and collection devices are disclosed for rapid, local PCR testing. The PCR testing system may be configured for use with a disposable sample collection device that includes a swab configured for collecting a biological sample from a patient; and a sample container configured to receive the swab and separate a bulk quantity of the biological sample from the swab for containment in a bulk collection chamber, which is located with the sample container, wherein the sample container is configured to meter a selected volume of the biological sample into a PCR sample tube, which contains a lyophilized master mix, releasably attachable to the sample container.

Provided herein are systems and methods for a point of care apparatus. The point of care apparatus includes a fluid container for receiving a biosample, an intermediate cap, and a cartridge having at least one microfluidic channel.

A filter insert, a sample vial incorporating a filter insert, a method of using a sample vial containing a filter insert for chemical analysis, and a sample vial kit including a filter insert. The filter insert includes a cylindrical body having a proximal end, a protrusion extending radially from the proximal end of the cylindrical body and configured to set on the open end of a sample vial, a distal end, a cavity extending longitudinally through the cylindrical body from the proximal end to the distal end, and a filter assembly coupled with the distal end of the cylindrical body.

Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers demonstrating sufficient accuracy and specificity for identifying kidney injuries. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of continuous monitoring for kidney injury.

The present disclosure provides a fluid delivery consumable for delivering a fluid dose to a bioreactor. The fluid delivery consumable comprising a vial for holding the fluid dose, the vial having an outlet and an open end opposite to the outlet, a plunger engaged with the open end and operable to urge the fluid dose toward the outlet, and a connector proximal to the outlet, the connector being attachable to the bioreactor and adapted to move the fluid dose from the vial to the bioreactor based on operation of the plunger.

A container for a reactive product including a container body having a neck delimiting a neck opening; a closure member comprising a puncturable closure membrane which tightly seals off the neck opening; a suction tube located in the container body and comprising a first end portion attached to the closure member and a second end portion extending in the proximity of the bottom of the container body; and a cap attached to the neck and comprising a passage opening which is located facing the puncturable closure membrane and the first end portion of the suction tube, the cap being configured so as to enable the penetration of a sampling needle through the passage opening and the puncturable closure membrane such that the sampling needle is fluidly connected to the suction tube, and so as to enable the penetration of a venting needle through the passage opening and the puncturable closure membrane such that the venting needle is fluidly connected to an internal volume of the container body.

The invention relates to a method and a system for providing fluids, comprising two components, wherein a first component is a container with at least one first reservoir for taking up a fluid and a second reservoir for ventilation of the system, wherein said first and second reservoir are sealed with a seal, and a second component which is a dock for taking up the container, wherein the dock comprises an inner bottom surface comprising first formations for fluid piercing of the container's at least one first reservoir for taking up a fluid and second formations for piercing of the container's second reservoir for ventilation, and wherein said inner bottom surface is a drain plate comprising a drain, wherein the container has fins on its outer edge which engage into two parallel arranged recesses at the inner side surface of the dock for fixing the container within the dock in a first position when the fins of the container engage in a first recess which is a storage snap fit or a second position when the fins of the container engage in second recess at the inner side surface which is a retain snap fit.

A top for a plasma storage container includes a top body that defines the structure of the top and seals an opening of the plasma storage container. The top also includes a first opening and a vent opening extending through the top body. A valve mechanism is located at least partially within the top body and includes an aperture therethrough. The aperture opens upon connection of a blunt cannula to provide access to the interior of the plasma storage container. The top also includes a vent filter. The vent filter allows air to vent through the vent opening during plasma collection.

A system for analyzing a physiological sample includes a cartridge configured to attach to the skin of a subject. The cartridge includes: a processing fluid pack that is configured to release a processing fluid stored therein, a diagnostic test strip, and a vacuum pin. The system also includes a lancet with a needle. The lancet is configured to deploy the needle upon engagement with the cartridge to draw a physiological sample from the subject. The vacuum pin is configured to create a vacuum within the cartridge to draw the released processing fluid and the drawn physiological sample to the diagnostic test strip.

A cartridge can comprise a first elastomeric membrane and a second elastomeric membrane, and portions of the elastomeric membranes which are sealed to each other can circumscribe unsealed portions of the membranes. In a resting state, the unsealed portion of the first elastomeric membrane abuts or is proximate to the unsealed portion of the second elastomeric membrane. One or more reagents can be injected between the unsealed portions of the first and second elastomeric membranes to push the unsealed portions apart from each other in this region of the membranes. The unsealed portions can be sequentially pushed apart in downstream regions to form a channel between the elastomeric membranes. Positively displaced fluid pushes the unsealed membrane portions apart to a volume that conforms to the volume of the fluid to minimize or prevent dead volume in the channel and thus minimize or prevent air bubbles in the fluid.