A method is taught for the accurate determination of the premature rupture of membranes (PROM), defined as spontaneous rupture of membranes before the onset of uterine contractions. More specifically, a lateral flow assay strip tests for at least two antigens to greatly limit or eliminate the possibility of false negatives. A built-in timer in the cassette holding the lateral flow assay further increases the accuracy of the test. A collection buffer vial with self-contained shipping and dropper caps and built-in stand is also taught.

A device and method for separating serum or plasma from blood cells in a whole blood specimen. The present invention uses a cap with a reservoir, such that blood cells are packed into the cap when the specimen container is centrifuged. When the cap is removed, the blood cells are also removed, and the serum or plasma is left in the specimen tube where it can be readily extracted by a pipette which is able to reach all the way to the bottom of the specimen tube minimizing the dead volume.

A container system for receiving a liquid sample has a receptacle including a substantially tubular portion for receiving a predetermined volume of the sample. The substantially tubular portion has a first open end and an at least partially openable second end; and a chamber at least partially surrounding the substantially tubular portion. The chamber has an at least partially open upper portion and a closed bottom.

A biological sample storage container includes a biological sample storage tube and a biological sample storage tube cap. The tube cap is a cap that is to be attached to the tube having a lower closed portion and an upper opening portion, and is for closing the upper opening portion. The tube cap includes a main body portion that enters the upper opening portion of the biological sample storage tube and closes the upper opening portion, an elongated biological sample adhering portion that extends downward from a lower face of the main body portion, and a flange that protrudes laterally outward from the main body portion. The biological sample adhering portion is cuttable and falls into the biological sample storage tube after being cut.

A bio sample collection device including: a housing; a cap part detachably fastened to the housing, and including a bio sample collector for collecting a bio sample; and a bio sample processing liquid storage unit storing bio sample processing liquid, the bio sample processing liquid storage unit being formed to be broken when the cap part is combined with the housing after bio sample is collected so that the bio sample processing liquid is mixed with the bio sample.

A blood clotting time measurement cartridge includes: an inlet on one end of a measurement flow channel and through which blood is introduced; a communication opening on the other end of the measurement flow channel and through which air suction or air pressure application or the blood introduced from the inlet is performed; a moving body arranged in the measurement flow channel moves; a clotting accelerator applied on at least one of a flow channel wall surface, which defines the measurement flow channel, and the moving body; and a detection area through which light is transmitted to a predetermined part in the measurement flow channel, and where it is possible to detect with light whether there is the moving body or the blood making a reciprocating motion in the measurement flow channel in association with air suction or air pressure application or the blood from the communication opening.

The present application provides a child-resistant liquid dispensing closure apparatus, which includes a plunger and pipet, and preferably a dosage measuring system that is integrated that appears as the plunger is withdrawn from the pipet. The closure may be used for a bottle containing a liquid for oral administration of solutions, syrups, suspensions, elixirs, tinctures, concentrates, and the like.

A device for analysing a sample comprising a nucleic acid to be captured and detected using a test strip are described. The device comprises a resilient biasing member disposed in an analysis chamber containing the test strip. The resilient biasing member exerts a force against the test strip sufficient to urge it into the sample chamber when it is in communication with the analysis chamber. This ensures that the test strip is reliably introduced into the sample chamber when it is in communication with the analysis chamber. In one embodiment, the sample chamber comprises guide members for guiding the test strip into the sample chamber. A free end of each guide member is shaped to prevent significant rotation of the test strip, so that the test strip is in correct alignment in the sample chamber for automatic reading of the test result, for example by a camera or optical reader.

Example implementations include a method of manufacturing a biochemical sensor by forming a fluid conduit in a microfluidic layer, forming an electrode on an electrode layer, forming a biochemical sensor on the electrode layer, bonding the electrode layer to a first surface of the microfluidic layer, and bonding a barrier layer to a second surface of the microfluidic layer. Example implementations also include a method of electrically detecting a biochemical by contacting an electrode array to a biological surface, obtaining a biofluid at the electrode array from the biological surface, obtaining a response current associated with the biofluid at the electrode array, and generating a quantitative biochemical response based at least partially on the response current. Example implementations further include applying a current to the biological surface. Example implementations further include filtering electrical interference at the electrode array. Example implementations further include generating a quantitative biochemical response based on the response current.

A method for separating and enriching sperm from a tissue sample comprises: obtaining a microfluidic separating system having an inlet end and an outlet end, and a membrane filter (e.g., hollow fiber membrane filter) fluidly connected to the outlet end; separating the tissue sample via the microfluidic separating system into a debris fluid volume and a sperm fluid volume; and enriching the sperm fluid volume by removing excess media via the membrane filter. A two-stage tissue sample separation system comprising: a microchannel structure defining a separation fluid channel to form a separation stage; an inlet end of the microchannel structure; an outlet end of the microchannel structure; and a membrane filter fluidly connected to the outlet end for removal of at least a portion of excess media in the tissue sample.