A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.

A carrier plate, which is used within an electrophoresis process, and to a holding device tailored to the carrier plate, the carrier plate having a region with a magnetic property and a positioning device. The magnetic property is designed to fix the carrier plate in the laboratory device. The positioning device is designed to guarantee a position of the carrier plate in the laboratory device.

A holder (40) for holding a stack (10) of coverslips (11) or specimen slides (11) has a bottom (20) having at least one side wall (21a, 21b, 22a, 22b) connected thereto, wherein an inner side of the bottom (20) is embodied for placement of the stack (10) of coverslips (11) or specimen slides (11) and carrying that stack (10), and an outer side of the bottom (20) and/or an outer side of the at least one side wall is configured to receive an identification label, such as an RFID (30), and the holder includes such the identification label, such as an RFID (30).

Microfluidic cartridge (10) comprising a sampling device (30) having a sealing ring (32) arranged to form a microfluidic chamber (31) when a support containing a biological sample is brought into contact with the sealing ring, and a microfluidic network device (13) configured to supply reagents to the microfluidic chamber. The sampling device further comprises inlet and outlet distribution networks (33a, 33b) in fluid communication with the microfluidic chamber and a slide holder (35) to guide and position said support containing a biological sample on the sampling device. The microfluidic network device comprises a plurality of reagent inlet channels (18) fluidly connectable to reagent sources, at least one reagent outlet channel (22) fluidly connected to the sampling device inlet distribution network (33a), and a plurality of valves (25) operable to selectively connect the inlet channels to the at least one outlet channel. The sampling device (30) and microfluidic network device (13) are formed on a common microfluidic support (12) as a single part.

A microscope slide-holder support having a plate-shaped body defining an upper body surface, an opposite lower body surface, and a body thickness defined between the upper body surface and the lower body surface is provided. The plate-shaped body has a through opening passing through the plate-shaped body between the upper body surface and the lower body surface, at least one slide seat to removably house a corresponding microscope slide at the upper body surface, and upper removable engagement means for engaging/disengaging the microscope slide to/from the plate-shaped body at a respective slide seat. The microscope slide-holder support has a collection plate coupable to the plate-shaped body for at least partially closing the through opening close to the lower body surface, the collection plate and the through opening being configured to jointly form a collection compartment in the microscope slide-holder support.

The disclosure is directed to a package for containing a plurality of substantially rectangular assay plates, each plate having a peripheral flange. In one embodiment, the package comprises a cavity having extending therein one or more sloped buttress elements spaced across at least a portion of a top corner, and one or more adjacent protrusions extending from the bottom and at least partially up one or both sidewalls, each set of protrusions forming grooves therebetween into which fit the flanges of respective assay plates. The package can comprise a transparent polymer through which product information located on the assay plates can be read or scanned.

An analytic plate or other substrate having a permanent etchable, laserable, and/or developable marking surface coating (referred to herein as an “etchable coating” or as a “developable coating”) that is present on at least a portion of any side or surface thereof and is used to deposit a permanent indicium thereon, and a method of using the analytic plate or substrate.

Disclosed are calibration techniques that can be implemented by a device that conducts biological tests. In certain embodiments, the device for testing a biological specimen includes a receiving mechanism to receive a carrier, a camera module arranged to capture imagery of the carrier, and a processor. Some examples of the processor can detect a calibration mode trigger. In calibration mode, the processor can divide the captured imagery into segments and selectively perform one or more calibration procedures for each segment. Then, the processor records a calibration result for each segment.

A matrix droplet extruder includes a casing; one or a plurality of reagent containers; a plurality of pneumatic connectors on the casing that are each configured to be connected to a pneumatic actuator to provide controlled pneumatic pressure to one or more of said plurality of the pneumatic connectors; a droplet matrix extrusion surface with one or a plurality of printing zones, each printing zone comprising an array of perforations; and a liquid management chip for dispensing one or more reagents from said one or a plurality of reagent containers through the array of perforations of said one or a plurality of printing zones, so as to repeatedly generate a matrix of droplets when applying the pneumatic pressure to said one or more reagents.

A system and method for automated single cell capture and processing is described, where the system includes a deck supporting and positioning a set of sample processing elements (including an integrated imaging subsystem); a gantry for actuating tools for interactions with the set of sample processing elements supported by the deck; and a base supporting various processing subsystems and a control subsystems in communication with the processing subsystems. The system can automatically execute workflows associated with single cell processing, including antibody detection, other protein detection, mRNA detection, and/or other applications associated with spatial transcriptomics.