A microfluidic apparatus for delivering droplets of a first fluid to droplets of a second fluid, comprising a main channel, with a carrier fluid carrying droplets of the second fluid, an auxiliary channel, fluidly coupled to the main channel at a first intersection via a first orifice with a first fluid interface, and at a second intersection downstream to the first intersection via a second orifice with a second fluid interface, wherein a flow of the carrier fluid induces a difference of pressure between the first and second orifice generating a balance condition such that a meniscus of the second fluid interface is maintained in the auxiliary channel, at the vicinity of the second orifice, wherein a balance deviation triggers a release of a volume of the first fluid from the second fluid interface into the main channel.

A first fluid handling device according to the present invention has: a first liquid introduction part; a first cleaning liquid introduction part; a first flow path through which a liquid introduced to the first liquid introduction part or to the first cleaning liquid introduction part flows; a second liquid introduction part; a second cleaning liquid introduction part; a second flow path through which a liquid introduced to the second liquid introduction part or to the second cleaning liquid introduction part flows; a third flow path which allows flowing therethrough of the liquid having flowed through the first flow path and the liquid having flowed through the second flow path; a first diaphragm valve that is disposed between the first and third flow paths; a second diaphragm valve that is disposed between the second and third flow paths; and a chamber that is connected to the third flow path.

A system and method sorts particles suspended in a fluid. The system includes a transverse flow filter and a microfluidic sorter. The transverse flow filter concentrates the particles in a retained portion of the fluid. The microfluidic sorter sorts the particles and includes a delivery channel and at least one sorting stage. The delivery channel is dimensioned to permit passage of all the particles in the retained fluid from the transverse flow filter. The delivery channel delivers the particles in the retained fluid to a respective input for each sorting stage and exhausts a remainder of both the particles and the retained fluid at a drain output. Each sorting stage has a labyrinth of interconnected passageways dimensioned to permit passage from the respective input to a respective output for the sorting stage of those of the particles smaller than a respective size for the sorting stage.

Microfluidic chips containing electrochemical biosensors are described. The electrochemical biosensors include a flow layer intersected by valves of a control layer, which control the fluid flow. The flow layer includes two zones, an analyte capture zone for mixing a sample with an analyte capture element, and a detection zone for detecting the analyte. Both zones include a rotary mixer for mixing, and where needed, trapping, washing, and flowing the captured analyte. The captured analyte is detected by the sensing region of the detection zone. The microfluidic chips may be integrated into devices for automated, fast, point-of-care determination of analyte concentration.

An embodiment provides a device for mixing at least two reagent fluids, the mixed at least two reagent fluids being used for the measurement of a chemical attribute of a sample, including: a housing; at least two inlet ports, each to receive fluid in a premix state; an outlet port to dispense fluid in a postmix state; and a surface of a lumen for mixing, located within the housing, having a predetermined length, wherein the surface of the lumen is located between the at least two inlet ports and the outlet port, wherein the at least two inlet ports transition into the surface of the lumen, wherein the predetermined length is of a length allowing for sufficient mixing of the fluids received by the at least two inlet ports, wherein the surface of the lumen comprises at least one anti-siphoning element and a plurality of weirs to create a disturbance of a fluid contained therein, wherein the at least two fluids each comprise a reagent for a measurement of a chemical attribute of a sample. Other aspects are described and claimed.

The microfluidic board comprises a plurality of matrix units, wherein each matrix unit is a stacked arrangement comprising a driving portion comprising an actuator, a pump portion in contact with the driving portion and comprising a pump, a channel portion in contact with the pump portion and comprising one or more channels, and a chamber portion in contact with the channel portion and comprising a chamber, wherein the one or more channels are configured to direct fluid between the pump and the chamber, and wherein the actuator is configured to generate a force to drive the pump upon receiving of an input energy.

A step-type inertial focusing microfluidic chip includes an arc-shaped channel having multiple stages connected in series. At least one stage of the arc-shaped channel is separated into a plurality of sub-channels distributed along a radial direction, one end of the multistage arc-shaped channel is provided with at least one fluid inlet and an inlet channel connecting the end of to the fluid inlet. The other end of the multistage arc-shaped channel is provided with a plurality of fluid outlets and a plurality of outlet channels connecting the other end to the fluid outlets. A radius of curvature of the arc-shaped channel is 2 to 50 mm. A cross-sectional width is 50-5000 microns, the cross-sectional height is 20-2000 microns, and a thickness of a sub-channel separation wall in the arc-shaped channel having the sub-channels is 10 to 1000 microns.

In one example in accordance with the present disclosure, am ejection system is described. The ejection system includes a fluid feed slot to supply fluid to a number of fluid ejection channels where each fluid ejection channel is a recirculating channel. Each fluid ejection channel includes a sensor to detect, in the fluid, a target particle to be ejected and a fluid ejector to eject the target particle from the fluid ejection channel. The ejection system also includes a controller to selectively activate the fluid ejector when the target particle presence is detected. Non-target particles are returned to the fluid feed slot past the fluid ejector.

An open microfluidic system is provided. The open microfluidic system including the extreme wettability of exclusive liquid repellency (ELR), open microchannels with high lateral resolution and low profile, various valve arrangements, capable of a broad range flow rates, and capable of spatially and temporally trapping particles in open fluid.

In various embodiments a capture surface for capturing high velocity and hypervelocity dust and ice particles is provided. In certain embodiments the capture surface is comprised of a soft metal that is chosen to optimize particle capture efficiency, to minimize thermal degradation of chemicals and biochemical in the particles, and to present the captured particles to an analyzer for chemical and biochemical analysis of the particles and their contents. In various embodiments capture chambers comprising one or more such capture surfaces are provided as well as methods of use thereof.