The invention provides a sample container arrangement comprising a carrier for at least one sample container and a tempering module, comprising at least one tempering element and being at least sectionally in contact with the carrier such that the at least one tempering element is suitable to temper the at least one sample container, wherein the sample container arrangement is such that the carrier is kept in contact to the tempering module by negative pressure relative to ambient pressure.

The present disclosure provides systems and methods for heating biological samples. Methods and systems of the present disclosure may be used for performing nucleic acid amplification to identify one or more targets in a nucleic acid sample of a subject.

A system and method comprise positioning a medical device within a subject. The medical device includes a plurality of compartments and each of the plurality of compartments includes a ferrous material. Further, each of the plurality of compartments is configured to hold a substance. The system and method further include delivering electromagnetic radiation, by an electromagnetic radiation source, to the medical device and varying, by a controller, an amount of the electromagnetic radiation delivered by the electromagnetic radiation source for selectively heating the ferrous material of at least one of the plurality of compartments and selectively releasing the substance held in the at least one of the plurality of compartments for managing a condition.

The present invention generally relates to a method which makes use of electrowetting to automate PCR amplification wherein the PCR reagents are contained in droplets, and further wherein the quantity of PCR product is monitored in real time thus enabling stopping amplification once a desired quantity of PCR product has been generated.

A detecting apparatus for at least one of DNA and RNA includes: a substrate; at least one chamber formed on the surface of the substrate; a plurality of nanostructures fixed on the internal surface of the at least one chamber; at least one light source configured to supply incident light on the at least one chamber; and a light-receiving unit configured to sense an optical signal from the nanostructures.

The present invention provides a tool that can analyze a target in a sample with simple operations and can be downsized, and an analysis method using the same. The analysis cell of the present invention includes: a main substrate: a sample inlet cover member; and a gas outlet cover member. The main substrate includes a flow path, an inlet for a sample, and a gas outlet, and the inlet and the gas outlet communicate with an outside. The inlet communicates with an upstream end portion of the flow path and the gas outlet communicates with a downstream end portion of the flow path. The flow path has a shape that expands from an upstream side toward a downstream side of the flow path. The sample inlet cover member is a liquid-tight member and can be fixed to the inlet when the sample inlet cover member is in use. The gas outlet cover member is a liquid-tight and gas-permeable member and can be fixed to the gas outlet when the gas outlet cover member is in use.

A diagnostic assay system includes a platform configured to receive a disposable cartridge having a sample chamber for receipt of an assay fluid, and an a PCR chamber disposed in fluid communication with the sample chamber for performing target amplification of the assay fluid. A heating source is disposed adjacent a heat exchange surface disposed along at least one side of the PCR chamber and is configured to conform to the contour of the heat exchange surface to accelerate target amplification of the assay fluid. The heating source introduces heat into the assay fluid from one side of the disposable cartridge and, in one embodiment, employs a conformal material interposing the heating source and the heat exchange surface to mitigate the formation of air pockets therebetween.

A molecular diagnostics apparatus which is adapted to perform DNA chain replication to one sample is provided, including a bracket, a central control module, a central control module coil, a rotational carrier, a detection module and a detection module coil. The central control module is disposed on the bracket. The central control module coil is coupled to the central control module. The rotational carrier is adapted to be rotated relative to the bracket, wherein the sample is disposed on the rotational carrier. The detection module is disposed on the rotational carrier. The detection module coil is coupled to the detection module. In a charging mode, the central control module makes the central control module coil provide an induced electromotive force. The detection module coil generates an induced current according to the induced electromotive force. The induced current is supplied to the detection module.

Instruments, methods, and kits are disclosed for performing fast thermocycling.

Devices are disclosed for amplifying and detecting analytes, including oligonucleotide targets. The devices may be used for point of care nucleic acid testing. Methods and assays of using the devices are also disclosed.