A centrifugal microfluidic technique for heat treating emulsion-divided independent reaction volumes (IRVs) within a centrifugal microfluidic chip, and displacing the emulsion into a monolayer presentation chamber (pc) for imaging. A deep treatment chamber (tc) is provided for the heat treatment, a nozzle having a hydrodynamic radius for forming the IRVs is provided for injecting a sample for the IRVs into the tc filled with a dense immiscible medium. The tc is adjacent a heat controlled element for collectively heat treating the IRVs within the tc, where the IRVs form a 3d packing arrangement. The tc is coupled to a presentation chamber (pc) by an opening through which the IRVs can be selectively displaced without collapsing. The pc is adjacent a window transparent to a wavelength for inspecting the pc.

The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.

A reaction processing vessel includes a substrate and a groove-like channel formed on the upper surface of the substrate. The channel includes a high temperature serpiginous channel, a medium temperature serpiginous channel, and a high temperature braking channel and a medium temperature braking channel that are adjacent to the high temperature serpiginous channel and the medium temperature serpiginous channel, respectively. The respective cross-sectional areas of the high temperature braking channel and the medium temperature braking channel are larger than the respective cross-sectional areas of the high temperature serpiginous channel and the medium temperature serpiginous channel, respectively.

Provided are a multi-channel isothermal amplification system and an operation method. The operation method comprises: a first step in which sample tubes are disposed in holes formed in a line in a heating block, respectively, wherein the heating block comprises: a first heating block area in which some of the plurality of holes are formed in a line; and a second heating block area in which the rest of the plurality of holes are formed in a line, and which is disposed to be in a line with the first heating block area, wherein the first heating block area and the second heating block area are spaced apart from each other at an interval as much as one hole area between two holes; and a second step in which an optical system moves in a longitudinal direction of the first heating block area and the second heating block area.

Methods and apparatus for a cooled chemical cabinet include a cooling duct configured to cool a heatsink coupled to a thermoelectric module (TEM). The cooling duct includes a fan configured to pull air into an inlet duct and onto the heatsink. The air pulled in by the fan absorbs the heat from the heatsink. The cooling duct further includes an exhaust duct connected to the fan and configured to expel the heated air. The exhaust duct is configured to expel the heated air outside the chemical cabinet and away from the TEM.

This device comprises: a casing with an upper surface including a sample-dripping portion receiving a liquid sample containing nucleic acid and being dripped from a nozzle; a reaction tube: outwardly projecting from an end of the casing; including a storage space therein; and being formed so as to be installed within a measurement apparatus; a filter carrying the nucleic acid contained in the liquid sample; a filter-supporting body stored within the casing to support the filter in a manner such that the filter is capable of taking: a contacting position wherein the filter contacts with the liquid sample right below the sample-dripping portion; and a reaction position wherein the filter is positioned within the storage space of the reaction tube; and absorbing material capable of taking: a press-attaching position wherein the absorbing material is press-attached to the filter in the contacting position so that the filter absorbs the liquid sample contacting therewith; and a separating position wherein the absorbing material is removed from the press-attaching position so that the filter is allowed to freely move.

A system, methods, and apparatus are described to collect and prepare single cells, nuclei, subcellular components, and biomolecules from specimens including tissues and in some embodiments use the single cells to form organoids or microtissues. The system can perform enzymatic and/or physical disruption of the tissue to dissociate it into single-cells and then use a hanging droplet method to form organoids or microtissues.

A modular fluid chip according to an embodiment of the present disclosure includes a body including at least one first hole which allows fluid to flow therethrough; and a housing receiving the body therein, and including a second hole which corresponds to the at least one first hole and allows the fluid to flow therethrough, and a fluid connection part which is connectable to another modular fluid chip.

A molecular diagnostics apparatus is provided. The molecular diagnostics apparatus is adapted to perform DNA chain replication to one sample. The molecular diagnostics apparatus includes a bracket, a central control module, a motor, a magnetic unit, a rotational carrier, a detection module and at least one power supply coil. The central control module is disposed on the bracket. The motor is disposed on the bracket, wherein the central control module drives the motor. The magnetic unit is disposed on the bracket, wherein the magnetic unit provides a magnetic field. The motor is adapted to rotate the rotational carrier. The rotational carrier is rotated relative to the bracket. The sample is disposed on the rotational carrier. The detection module is disposed on the rotational carrier. The power supply coil is coupled to the detection module, and disposed on the rotational carrier. The molecular diagnostics apparatus of the embodiment has a simpler structure and better reliability.

The invention relates to a device and method for in situ temperature-induced antigen retrieval of samples wherein all steps are performed under a pressure higher than the atmospheric pressure on a sample immobilized on a sample support which can be further subjected to staining and imaging on the same sample support, optionally by cycle multiplexing that enables imaging of various molecular targets through multi-molecular read-outs on the same sample in a rapid, highly sensitive and reliable manner.