A thermal cycling device includes a thermally-conductive carrier, a temperature adjustment device, a storage tank, and a liquid delivery device. The temperature adjustment device is thermally coupled with the thermally-conductive carrier. The storage tank is disposed corresponding to and abuts against the temperature adjustment device, or the temperature adjustment device is at least partially disposed in the storage tank. The liquid delivery device communicates with the storage tank. A temperature control method for the thermal cycling device can control whether liquid contacts the temperature adjustment device through the liquid delivery device in coordination with whether the temperature adjustment device heats the thermally-conductive carrier, so as to produce rapid heating and heat dissipation effects.

This disclosure relates to apparatus and methods for thermally cycling a sample. Particular embodiments comprise a first pivot arm configured to pivot around a first pivot axis; a second pivot arm configured to pivot around a second pivot axis; a first thermal mass and a second thermal mass coupled to the first pivot arm; and a third thermal mass and a fourth thermal mass coupled to the second pivot arm, wherein the first and third thermal masses are proximal to the sample when the first and second pivot arms are in a first position, and the second and fourth thermal masses are proximal to the sample when the first and second pivot arms are in a second position.

Provided is a temperature control system applied to an apparatus for analyzing a sample using a pipette nozzle and a reaction container, including a pipette tip temperature controller that heats a pipette tip which is fitted on the pipette nozzle and aspirates or discharges liquid and a reaction container temperature controller that heats the reaction container. The pipette tip temperature controller heats, in a concentrated manner, at least a distal end portion of the pipette tip of the pipette nozzle located at a predetermined heating position with hot air emitted from a heat source and is configured such that a distal end is capable of arriving at the reaction container by lowering the pipette nozzle from the heating position.

The invention(s) cover systems and methods for target detection in a multiplexed and rapid manner. Embodiments of the system can include: a base substrate; and an array of sample processing regions defined at a broad surface of the base substrate, wherein each of the array of sample processing regions includes: a set of microwell subarrays arranged in a gradient by volumetric capacity between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions. The system can support methods, with example implementation by an automated platform, for returning preliminary results from a subset of microwells of the samples processing regions, as well as results pertaining to specific and non-specific amplification, for multiple targets of a sample.

A system for precision temperature control of thermal bead baths used in biological laboratories to heat biological samples. An insulated outer shell and an inner shell sealed together to form a recirculation pathway. The inner shell has an air extraction port opening into the recirculation pathway and at least one air injection port opening into the recirculation pathway. A fan in the recirculation pathway draws air through the air extraction port. A thermal sensor is connected to a control and is disposed in close proximity to one of the air injection ports. Thermal beads are placed in a mesh basket inside the inner shell. The fan draws air from the inner shell through the beads and into the recirculation pathway, where the air is heated by a thermal element. The air flows past the thermal element and through the air injection ports back into the inner shell.

The present invention relates to an apparatus for performing a nucleic acid amplification reaction and a fluorescence detection device for reaction analysis. The nucleic acid amplification apparatus of the present invention uses a plurality of blocks having different reaction temperatures by independent temperature control and the movement between the blocks is performed along sliding recesses formed in the blocks, enabling to greatly shorten the total amplification time (TAT). In the fluorescence detection device of the present invention, the positions of the light source and the photodetector are very unique for the reaction vessel in which an excitation light is provided and an emission light is generated.

The present disclosure provides an analysis device for a detection chip, an analysis system and a method of operating the analysis device. The analysis device includes a loading part, a temperature control part and a signal detection part. The loading part is configured to receive and hold the detection chip in use and is capable of moving the detection chip. The temperature control part includes a heater and a cooler, the heater is configured to heat the detection chip and the cooler is configured to cool the detection chip. The signal detection part includes an optical sensor. The optical sensor is configured to receive light from the detection chip and perform detection according to the light.

The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.

Provided are a multi-channel isothermal amplification system and an operation method. The operation method comprises: a first step in which sample tubes are disposed in holes formed in a line in a heating block, respectively, wherein the heating block comprises: a first heating block area in which some of the plurality of holes are formed in a line; and a second heating block area in which the rest of the plurality of holes are formed in a line, and which is disposed to be in a line with the first heating block area, wherein the first heating block area and the second heating block area are spaced apart from each other at an interval as much as one hole area between two holes; and a second step in which an optical system moves in a longitudinal direction of the first heating block area and the second heating block area.

Methods and apparatus for a cooled chemical cabinet include a cooling duct configured to cool a heatsink coupled to a thermoelectric module (TEM). The cooling duct includes a fan configured to pull air into an inlet duct and onto the heatsink. The air pulled in by the fan absorbs the heat from the heatsink. The cooling duct further includes an exhaust duct connected to the fan and configured to expel the heated air. The exhaust duct is configured to expel the heated air outside the chemical cabinet and away from the TEM.