A fluidic device (1) configured to drive movement of fluid under centrifugal force comprises a central region about a central rotational axis (X) of the device and a peripheral region extending radially outwards from the central region. A fluid reservoir (4) provided in the central region of the device receives a fluid sample and communicates with at least one fluidic system (6), which extends radially outwards from the fluid reservoir (4) into the peripheral region of the device. Each fluidic system (6) comprises a fluid analysis chamber (12) configured to retain a portion of a fluid sample for analysis. A fluidic channel arrangement (26) is configured to enable fluid communication between the fluid reservoir (4) and the fluid analysis chamber (12), and movement of the fluid sample through the fluidic channel arrangement is driven by the centrifugal force created by rotational motion of the device about the central rotational axis (X). A valve mechanism (8) is arranged between the fluid reservoir (4) and the analysis chamber (12) and is configured to prevent fluid flow through that portion of the fluidic channel arrangement (26) when the speed of rotation of the device is less than a predetermined value. A cut-out portion of the device (24) may help to correctly locate the fluidic device (1) within an assay apparatus. An apparatus for driving rotational motion of the fluidic device and a method for moving a fluid sample within the fluidic device are also described.

A two-piece assembly for sequential through-matrix processing of solutions and/or solids is provided, the assembly having an inner vial which maintains and holds the matrix and an outer vial which is configured to receive the inner vial at the upper or lower parked positions, to respectively allow or impede passage of the solution through the matrix of the upper vial. Captured molecules can be treated with enzymes and/or chemistries in situ in the matrix, and without the need for the use of strong chaotropic agents such as urea or detergents like SDS.

Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. An apparatus may include a first layer being substantially transparent. A second layer may be coupled to the first layer. The second layer may be substantially absorbent to infrared radiation. The second layer and the first layer may collectively define a set of wells. The first layer may define a base for each well of the set of wells. The second layer may define an opening for each well of the set of wells. At least one of the first layer and the second layer may define a sidewall for each well of the set of wells.

A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a syringe and a syringe holder, the syringe having a proximal top with a luer port, a sidewall extending from the top forming a syringe tube, and a plunger slidably disposed inside the syringe tube, the plunger forming a sealing engagement with the sidewall, the syringe holder defining a cavity for receiving the syringe, wherein a distal end of the syringe tube is at least partially closed by the syringe holder after the plunger is placed inside the syringe tube. The method includes receiving a fluid containing cells in the syringe; placing the syringe and syringe holder into a centrifuge; exposing the syringe and syringe holder to elevated g force in the centrifuge, the syringe holder being in physical contact with the sidewall on the distal end to provide support and prevent fluid from leaking outside the syringe; removing the syringe from the centrifuge; and extracting separated layers containing cells using the luer port of the syringe as an access port.

Provided is a centrifugal separation container for separating a material from tissue and body fluids by using a centrifugal force, including: a first container; a second container; a first piston positioned in the inside of the first container and configured to be movable up and down in the inside of the first container; an elastic body positioned below the first piston in the inside of the first container and configured to elastically bias the first piston upward; a first connecting duct having one end connected to the first container and the other end connected to the second container; and a first control valve operating by a centrifugal force and configured to open and close the first connecting duct.

A centrifugal piston according to an embodiment comprises: a piston body defining a path which extends from the front of the piston to the rear of the piston, and through which substances at the front of the piston can move to the rear of the piston; and a valve disposed on the path and configured to selectively open or block the path, wherein, during centrifugation in which centrifugal force acts on the piston, the substances at the front of the piston are centrifuged while the valve is blocking the path, and, when an external force is applied to the piston while the centrifugal force does not act on the piston, the valve moves freely relative to the piston body, and when the valve opens the path, at least a portion of the substances at the front of the piston can move to the rear of the piston.

A discoid sample holder (1), on which a device (2) for carrying out at least one processing step is formed. According to the invention, a slot (3), into which a sampling instrument (4) can be introduced, and a mechanism (5) for releasing a sample from the sampling instrument (4) arranged in the receptacle (3), is formed in the sample holder.

A piston for centrifugation according to one embodiment may include: a body; a valve which can move inside the body to the front side and the rear side of the body according to an applied external force; a fluid channel through which a fluid flows from the front side of the body to the rear side of the body; and a valve support for guiding movement of the valve.

The transfer systems, devices, kits, and methods described here may be used to facilitate the transfer of a material (e.g., a fluid) to or from a donor container, e.g., to or from wells of a donor plate while leaving target agents attached to the wells. The systems may comprise a donor plate, a transfer adapter, and a receiver plate that may be coupled to form a transfer assembly. The transfer adapter may comprise a planar sheet and a plurality of openings, and it may be configured to regulate the flow of fluid out of the wells. The transfer assembly may be placed into a centrifuge, and the fluid transfer force produced by the centrifuge may cause fluid to flow out of the wells of the donor plate, through the openings in the transfer adapter, and into the receiver plate.

A centrifugal microfluidic technique for heat treating emulsion-divided independent reaction volumes (IRVs) within a centrifugal microfluidic chip, and displacing the emulsion into a monolayer presentation chamber (pc) for imaging. A deep treatment chamber (tc) is provided for the heat treatment, a nozzle having a hydrodynamic radius for forming the IRVs is provided for injecting a sample for the IRVs into the tc filled with a dense immiscible medium. The tc is adjacent a heat controlled element for collectively heat treating the IRVs within the tc, where the IRVs form a 3d packing arrangement. The tc is coupled to a presentation chamber (pc) by an opening through which the IRVs can be selectively displaced without collapsing. The pc is adjacent a window transparent to a wavelength for inspecting the pc.