The present invention relates to a separable cassette for measuring glycated hemoglobin. It is easy to use the separable cassette for measuring glycated hemoglobin of the present invention since a reagent is sequentially leaked during the rotation thereof. In addition, there is no need to shake the reagent beforehand, as the reagent without residual reagent is fully discharged by the rotation. Therefore, the measurement result is accurate because an error between the amount of the reagent used and the amount of sample blood is small.

The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.

Examples herein involve sorting a droplet including a biologic sample. In a particular example, sorting a droplet including a biologic sample includes generating a droplet including a biologic sample and a pH sensitive surfactant, and heating a nucleic acid molecule in the biologic sample. The pH sensitive surfactant may change the surface tension of the droplet responsive to amplification of the nucleic acid molecule. The droplet may be sorted into one of a plurality of sorting lanes based on the surface tension of the droplet, where a sorting lane among the plurality of sorting lanes is associated with droplets including the amplified nucleic acid molecule. A determination of whether the droplet includes the amplified nucleic acid molecule may be performed by detecting passage of the droplet in one of the plurality of sorting lanes.

A biological sample reaction vessel comprising a reagent storage portion and a push rod movable relative to the reagent storage portion is provided. The reagent storage portion comprises at least one reagent containing cavity, and the reagent containing cavity is sealed by a sealing element; and the push rod is connected to the sealing element, and the push rod is used for cooperation with an external device to separate the sealing element from the reagent storage portion. In reaction, the biological sample reaction vessel cooperates with a test cassette. By inserting the biological sample reaction vessel into the external device, the reagent in the reagent storage portion can be released rapidly.

A microfluidic chip for culturing and real-time monitoring of multicellular tissues and use method thereof. The chip comprises a glass substrate layer, and a PDMS microchannel layer located on the glass substrate layer, wherein the glass substrate layer comprises a glass substrate, and a plurality of microelectrodes thereon; the PDMS microchannel comprises a plurality of independent microfluidic channels; the microelectrodes on the glass substrate are in one-to-one correspondence with the microfluidic channels in the PDMS microchannel layer; and the microelectrodes are electrically connected to an external circuit. The use method comprises: cell capture, cell or tissue culture, electrical impedance spectroscopy detection, and tissue release.

Metered dispensing of a microfluidic amount of fluid from a reservoir comprises a pressure device which applies a discharge pressure for fluid ejection via a discharge line through a valve arrangement. The valve device has a first valve with a minimum closing time and a second valve with a minimum opening time. A control device provides control signals for operation for metered dispensing of the amount of fluid as follows: a shortened minimum opening time for freeing the discharge line for the fluid flow, which time is shorter than the minimum opening time of the second valve; and a shortened minimum closing time for closing the discharge line for the fluid flow, which time is shorter than the minimum closing time of the first valve. Furthermore, a hand-held device for locally piercing human or animal skin is disclosed.

The present invention relates to a sample container having a new structure to effectively transfer a sample. A sample container according to the present invention includes: a container main body 10 that is formed in a cup shape having an open top surface, and a coupling hole 11 opened in a vertical direction is formed on one side of the container main body 10; a closed and sealed cover 20 that is coupled to an upper end of the container main body 10 to close and seal the container main body 10; and a detachably coupled collection tube 30 that is formed in the shape of a tube that extends in a vertical direction while having an open top surface, and is detachably coupled to the coupling hole 11, wherein a slope 12 that is inclined downward to the inside of the container main body 10 is formed on one side of an external circumferential surface of the container main body 10, wherein a recess portion 13 of which a lower end is open, and the recess portion 13 is formed on one side of the external circumferential surface of the container main body 10, and wherein the coupling hole 11 is formed to penetrate top and bottom surfaces of the recess portion 13, and the coupling hole 11 is formed on the top surface of the recess portion 13, accordingly, there is a merit that, after containing urine in the container main body 10 and combining the closed and sealed cover 20, the container main body 10 can be tilted to easily transfer urine to the collection tube 30 and the urine can be prevented from outflowing and contaminating the surrounding area, being contaminated, or being mistakenly switched.

Devices and methods are provided that permit efficient and selective separation of liquid biological specimens into at least two constituent components to facilitate subsequent quantitative and qualitative analysis on at least one analyte of interest in at least one of the components. The devices generally include one or more sample deposition regions supported on a base. Each sample deposition region includes a separation membrane for separating the liquid biological specimen into two different fractions. The first fraction is trapped by the separation membrane while the second fraction passes through the separation membrane and into a respective collection membrane. The separation and collection membranes are easily separable from the devices and can be utilized for further processing and analysis.

A sampling kit for tissue including a reaction chamber and a sampling device configured for mounting in the reaction chamber and providing a reaction volume defined between the base of the reaction chamber and the sampling device. The sampling device has a proximal handling portion and a distal scraping portion comprising a scraping formation configured to collect a sample of tissue when the distal scraping portion is rubbed against a surface of the tissue. The sampling device comprises an internal lumen configured for the supply of reaction liquid from a distal end of the tissue sampling device to the reaction volume via a distal aperture disposed in the distal scraping portion when the tissue sampling device is mounted in the reaction chamber. An automated high-throughput sampling and indexing system is also described.

Provided herein are systems and methods for a point of need testing system. In some embodiments, the point of need testing system includes a first collector and a sample amplifier. The first collector is configured to collect a first biofluid sample. The sample amplifier includes an inlet dimensioned to receive the first biofluid sample. The sample amplifier further includes a filter, a heater, and a second collector. In some embodiments, a reader can be used with the sample amplifier to read a second biofluid produced by the sample amplifier.