An integrated magnetic microbead processing apparatus includes a microplate having magnetic microbeads in microwells. A bottom of the microplate includes cavities between the microwells. A heating/cooling plate supports a base of the microplate and has a plurality of holes. A vertically movable magnet support plate includes a plurality of magnetic pins, each of which can protrude through one hole in the plurality of holes of the heating plate and into the cavity of the microplate. The magnetic pins are height adjustable. A shaker is operably connected to the microplate and is configured to shake the microplate, the heating/cooling plate, the magnetic support plate.

A magnetic separator includes a housing defining a product flow path, a drawer moveable between a first position and a second position, a magnet operatively connected to the drawer, the magnet positioned within the product flow path when in the first position and the magnet withdrawn from the flow path when in the second position, and a stripper plate frame attached to the housing. A stripper plate is fixed to the stripper plate frame that conforms with the magnet and through which the magnet passes as the drawer is moved between the first and second positions. An anti-rotation mechanism includes a slot that engages along a length of a shoulder such that. When the anti-rotation mechanism is positioned having the slot over the shoulder, the magnet is prevented from moving from the axially locked position. The shoulder extends beyond an outer surface of the anti-rotation mechanism.

A magnetic separator includes a housing defining a product flow path, a drawer moveable between a first position and a second position, a magnet operatively connected to the drawer, the magnet positioned within the product flow path when in the first position and the magnet withdrawn from the flow path when in the second position, and a stripper plate frame attached to the housing. A stripper plate is fixed to the stripper plate frame that conforms with the magnet and through which the magnet passes as the drawer is moved between the first and second positions. An anti-rotation mechanism includes a slot that engages along a length of a shoulder such that. When the anti-rotation mechanism is positioned having the slot over the shoulder, the magnet is prevented from moving from the axially locked position. The shoulder extends beyond an outer surface of the anti-rotation mechanism.

An apparatus for resuspending or maintaining suspension of magnetic beads in a reagent tray includes a di-pole magnet assembly disposed proximate the reagent tray. The di-pole magnet assembly inducing a static magnetic field having an amplitude gradient in a material disposed in the reagent tray. The di-pole magnet assembly magnetic field is movable with respect to the reagent tray. In some embodiments the magnetic field or the magnet assembly is movable linearly, rotationally or both linearly and rotationally with respect to the reagent tray.

An apparatus for resuspending or maintaining suspension of magnetic beads in a reagent tray includes a di-pole magnet assembly disposed proximate the reagent tray. The di-pole magnet assembly inducing a static magnetic field having an amplitude gradient in a material disposed in the reagent tray. The di-pole magnet assembly magnetic field is movable with respect to the reagent tray. In some embodiments the magnetic field or the magnet assembly is movable linearly, rotationally or both linearly and rotationally with respect to the reagent tray.

An apparatus for providing thermal and magnetic energy to a receptacle containing a reaction mixture and a magnetic retention member. The apparatus can also control heating of a reaction mixture, and bring about a separation of magnetic particles from the reaction mixture. The reaction mixture typically comprises polynucleotides from a biological sample that are being brought into a PCR-ready form.

A substrate treating apparatus includes a chamber defining a chamber cavity, a substrate carrier movable in a first direction inside of the chamber cavity, and a filter disposed inside the chamber cavity, defining an opening through which the substrate carrier passes, and including a magnet filter disposed in the opening and being rotatable.

A substrate treating apparatus includes a chamber defining a chamber cavity, a substrate carrier movable in a first direction inside of the chamber cavity, and a filter disposed inside the chamber cavity, defining an opening through which the substrate carrier passes, and including a magnet filter disposed in the opening and being rotatable.

A separation device is described. The separation device includes a rack, a turntable rotatably disposed on the rack; and at least one magnetic element disposed on the turntable. The turntable includes a top surface, and the magnetic element is recessed in or flush with the top surface. The separation device includes a separation membrane detachably disposed on the top surface. In some cases, the at least one magnetic element comprises a plurality of magnetic elements, and the plurality of magnetic elements are spaced apart along a circumferential direction of the turntable. The separation device and a material separation method disclosed are capable of reducing impurities in a slurry.

A separation device is described. The separation device includes a rack, a turntable rotatably disposed on the rack; and at least one magnetic element disposed on the turntable. The turntable includes a top surface, and the magnetic element is recessed in or flush with the top surface. The separation device includes a separation membrane detachably disposed on the top surface. In some cases, the at least one magnetic element comprises a plurality of magnetic elements, and the plurality of magnetic elements are spaced apart along a circumferential direction of the turntable. The separation device and a material separation method disclosed are capable of reducing impurities in a slurry.