The present invention relates to a centrifuge rotor with a rotor body and a receptacle arranged centrally therein for receiving a drive head of a drive shaft of a centrifuge which can be rotated about an axis of rotation (R), and sample receptacles for accommodating a plurality of sample containers. A holding crown is arranged on a top side (O) of the rotor body facing away from an insertion side (E) of the drive head, said holding crown having an annular base body, which encloses a central opening, and prongs extending upward away from the top side (O), wherein the holding crown is arranged in such a way that the axis of rotation (R) runs through the central opening. The present invention further relates to a holding crown for use with a centrifuge rotor and having an annular base body enclosing a central opening and prongs emanating from the base body and extending upward, wherein the prongs are offset at least in the region of their free ends by a spacing (A) from an inner edge of the base body. The present invention further relates to a holding crown arrangement comprising the holding crown, and a centrifuge comprising the centrifuge rotor, the holding crown or the holding crown arrangement.

A system for separating and transferring phases of a fluid through centrifugation including a centrifuge having a rotating axis, a platform that is rotatable around the rotating axis; and a device for separating and transferring the phases of the fluid. The device includes a separating container and a receiving container connected to the separating container through a connecting channel. A passive valve system is provided in the connecting channel. The device is mounted in the centrifuge platform such that in use at a first predefined range of centrifugal force a fluid provided within the separating container is separated into phases and at a second predefined range of centrifugal force the valve system opens, thereby transferring a phase of the fluid from the separating container to the receiving container.

Embodiments of a system box for holding a bag system and methods for separating composite liquids are described. In embodiments, a bag system may be a blood bag system used to collect blood, separate the blood into components, store the components, and utilize the components in patients. The system box may hold the blood bag system. Processes can then be performed to separate components from the blood.

A blood collection tube for physically separating the plasma and red blood cell fractions of a centrifuged sample is described. The blood collection tube has an elastomeric sleeve with rigid tube segments at both ends. Following blood collection and centrifugation, the elastomeric sleeve may be twisted to constrict its inner diameter and physically separate the two fractions. The blood collection tube may be secured in this position with a pin and a clamp, and further with an adhesive tape with pH paper. This enables blood samples to be transferred over long distances to a central lab facility without spoiling.

A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that the first internal pressure becomes equal to the second internal pressure in a state in which operation of a collection and returning pump (100) is stopped during at least one of a collection operation and a returning operation of a first cycle.

A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that, during a blood returning operation, the first internal pressure calculated by the first internal pressure calculation unit (110) becomes equal to the second internal pressure calculated by the second internal pressure calculation unit (112).

A biological component collection system and a circuit internal pressure acquisition method are provided, which are capable of accurately measuring the circuit internal pressure. A centrifugal separation device of a blood component collection system comprises an estimated data calculation unit that calculates estimated data B on the basis of initial data A, and a correction unit that corrects the estimated data B in a manner so that the internal pressure calculated by a first internal pressure calculation unit becomes equivalent to the internal pressure calculated by a second internal pressure calculation unit.

A centrifugal separation device of a blood component collection system comprises a data acquisition unit that acquires initial data A, an estimated data calculation unit that calculates estimated data B on the basis of the initial data A, a reaction force calculation unit which calculates a reaction force of a first applied load measurement unit on the basis of the estimated data B, and an internal pressure calculation unit that calculates an internal pressure of the first applied load measurement unit, based on the reaction force and a load detected by a first load detecting unit.

Disclosed is a centrifugal separation chamber (100) rotatable about an axis (AR) and having a variable volume separation space (116) therewithin and a port (102) in fluid communication with the volume for filling and emptying the volume, the chamber including a relatively rigid portion (104) proximal to the port which has walls defining a part of the volume and arranged to provide reducing dimensions of the volume toward the port, the chamber further including a flexible portion (106) distal to the port for providing said variable volume, the flexible portion including a mechanical interface (110) for transmitting movement to the flexible portion to cause said variable volume.

A vial and system are configured to simplify fluid input and extraction therefrom. The vial has a first end opposite a second end and with a collapsible sidewall. The sidewall can be collapsed, such as by imparting a differential pressure between an interior and exterior of the vial, for simplified fluid extraction and smooth extraction without disturbing boundaries between separated components. The vial typically has a bulb at a first end and a neck extending away from the bulb and toward the second end. An inlet spaced from the first end can be configured to attach to various different interfaces or processing elements for input and output of fluids. A support cup can be provided for use with the vial during centrifugation to allow the vial to withstand any centrifugation forces. Various fluid processing methodologies are supported by the collapsible vial, especially including methods of separation of components of blood.