B22F1/147

Method of obtaining a pharmaceutical agent used for inhibiting the proliferation of tumor cells

The given invention is related to the field of medicine, namely to experimental research in oncology, and can be used to obtain a pharmaceutical agent for inhibiting the proliferation of HeLa cervical cancer cells. It entails the use of a metal powder obtained in a gaseous medium by means of an electric explosion of a wire made of low-carbon steel carried out with a specific energy of 7-18 KJ/g and a pulse duration of 1.2-2 s. The explosion is carried out inside a reactor that is pre-evacuated to a residual pressure of 10.sup.2 Pa. and then filled with carbon monoxide to a pressure of 10.sup.5 Pa at a gas circulation rate flow of 10 m/s. The products of the explosion deposited in a hopper are passivated in air for at least 48 hours. The resulting powder is extracted and mixed with a solution of the RPMI-1640 nutrient medium with L-glutamine, a pH of 7.2, in the proportion of the mass of the powder to the volume of the specified solution from 1:10 to 2.7:10. The solution is then centrifuged until the phases are separated. The liquid phase is decanted and used as a pharmaceutical agent. The purpose of the given invention is to expand the arsenal of tools for inhibiting the proliferation of tumor cells.

FeNi ordered alloy structural body and method for manufacturing the same
12614653 · 2026-04-28 · ·

A FeNi ordered alloy structural body includes a support having a surface, and particles disposed on the surface of the support with gaps therebetween. Each of the particles contains an L1.sub.0-type FeNi ordered alloy phase. In a method for manufacturing the FeNi ordered alloy structural body, the support is prepared, and particles of an FeNi disordered alloy are dispersed on the surface of the support with gaps therebetween. A nitriding treatment is performed to the particles of the FeNi disordered alloy to form particles in which nitrogen is incorporated. After the nitriding treatment, a denitrification treatment is performed to desorb the nitrogen from the particles, thereby to form the particles containing the L1.sub.0-type FeNi ordered alloy phase.