Provided are a production method of a mold having a recessed pattern, and a manufacturing method of a pattern sheet having good accuracy and excellent productivity. The production method of a mold includes: a step of preparing an electroform having a protruding pattern and a mold having a first mold and a second mold forming a cavity; a step of fixing the electroform excluding an end portion of the electroform to the first mold; a clamping step of clamping the electroform excluding the end portion of the electroform and a region of the protruding pattern between the first mold and the second mold to form the cavity; and an injection step of filling the cavity with a resin.

A method and apparatus for molding non-pneumatic wheels is provided. The exemplary method and apparatus allow for the use of the same molding system to manufacture wheels with different hub constructions. Different configurations of removable mold elements are utilized within the same molding system to provide wheels with different hub constructions.

Mould for producing plastic items obtained by the injection of thermoplastic material of the “hot melt” or polyamide type, the mould being made of flexible vulcanised silicone, rubber or other elastomers, the mould being formed by two parts which, when facing each other and attached, generate a series of compartments and channels that allow for the introduction of the melted thermoplastic material and the filling of the cavities with the shape of the item desired, and, in turn, allow for a vacuum to be generated, also removing the inside air from the mould by means of a series of conduits and channels; and a method or methodology for producing said plastic items by means of said mould, allowing for the reproduction of short and medium series of items produced with plastic materials, and in which a control system and a mould incorporating a means to be identified can be added to the method.

An apparatus for making a three-dimensionally curved object, said apparatus comprising a membrane having a moulding surface, which is configurable into a predetermined shape by individually adjusting an array of actuators acting on the surface opposite the moulding surface of said membrane, wherein the membrane is a ferromagnetic membrane and the actuators are provided with magnetic joints at the distal ends of said actuators.

A transdermal drug delivery patch includes a flexible base layer, and a plurality of microneedles disposed at one surface of the base layer and including a biodegradable polymer and a drug. Each of a plurality of microneedles is formed as a star-shaped pyramid including a plurality of protrusions extending in a radial direction, and a concave shape is formed between two protrusions adjacent along a circumferential direction among a plurality of protrusions.

A transdermal drug delivery patch according to an exemplary embodiment of the present invention includes: a flexible base layer; and a plurality of microneedle disposed at one surface of the base layer. Each of the plurality of microneedles includes a biodegradable polymer and a drug and has an empty space inside. Each of the plurality of microneedles is formed as a star-shaped pyramid including a plurality of protrusions extending in a radial direction, and a part between two protrusions adjacent along the circumferential direction among the plurality of protrusions is concave.

A composite forming method includes manufacturing either one of a composite structure body and a dry preform having a hollow region, and pulling a core out of the hollow region. In the manufacturing, a rubber-made core having a tubular structure is disposed at a portion that forms the hollow region of either one of the composite structure body and the dry preform. The core has a thickness varied in a direction perpendicular to a longitudinal direction to be foldable inward at a thin portion. In the pulling, the core is folded inward with air being discharged from an inside of the core after either one of the composite structure body and the dry preform is manufactured.

A method for manufacturing curved composite material omega stringers, comprising: automatic tape laying-up in an ATL machine, an AFP machine or a FLU machine and automatic cutting of the contour, to achieve a straight preform with reinforcements; flat forming to obtain an omega shape on the straight preform to transform it into a straight omega shaped preform; and curve forming the straight omega shaped preform by placing it in a flexible tool comprising a longitudinally embedded stiff band and a laminate clamping arrangement, the laminate clamping arrangement being located in extreme positions of the flexible tool, the flexible tool being covered by a mechanical closing arrangement, such that a head of the straight omega shaped preform has reinforcements on both extremes, the reinforcements being held by the laminate clamping arrangement during the forming process, and afterwards the straight omega shaped preform is heated and transformed into a curved omega stringer.

Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer (110) on needle-like recess portions (42) of a mold (50) having the needle-like recess portions (42), a step of supplying a polymer layer forming solution (112) to the inside of a step portion (52) of the mold (50), a step of drying the polymer layer forming solution (112) so as to form a polymer layer (114) and a transdermal absorption sheet (120), and a step of peeling off the transdermal absorption sheet (120) from the mold (50). In the step of peeling off, pressing force is applied to a part of the step portion (52) in a second direction (B) opposite to a first direction (A) in which the transdermal absorption sheet (120) is released from the mold (50), and the transdermal absorption sheet (120) is aspirated with a vacuum suction pad (160) from a side opposite to the mold (50) so that the transdermal absorption sheet (120) is peeled off from the mold (50) in the first direction (A).

Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.